Experimental Brain Research

, Volume 144, Issue 1, pp 122–126 | Cite as

Investigation of age-related variations in biogenic magnetite levels in the human hippocampus

  • Jon Dobson
Research Note


The magnetic properties of human hippocampal tissue from 23 subjects (15 epilepsy patients and eight cadavers with no neuropathology) were analysed and tissue concentrations of magnetic material were calculated. The biogenic iron oxide magnetite (Fe3O4) is the dominant source of magnetisation in the tissue. Analysis of the group as a whole revealed no significant trend towards either increasing or decreasing magnetite concentration with age. Separate analysis of male and female subjects, however, reveals a trend towards increasing magnetite concentration with age in males. This trend is not seen in females and may have implications for iron metabolism and neurological disorders associated with disruptions in normal iron homeostasis.


Magnetite Hippocampus Epilepsy Iron oxide Neurodegenerative disease 


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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  1. 1.Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical PhysicsKeele UniversityStoke-on-TrentUK

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