Skip to main content

Advertisement

Log in

Modulation of rodent cortical motor excitability by somatosensory input

  • Research Article
  • Published:
Experimental Brain Research Aims and scope Submit manuscript

Abstract.

It is assumed that somatosensory input is required for motor learning and recovery from focal brain injury. In rodents and other mammals, corticocortical projections between somatosensory and motor cortices are modified by patterned input. Whether and how motor cortex function is modulated by somatosensory input to support motor learning is largely unknown. Recent human evidence suggests that input changes motor excitability. Using transcranial magnetic stimulation (TMS), this study tested whether motor cortex excitability is affected by patterned somatosensory stimulation in rodents. Motor potentials evoked in gastrocnemius muscles in response to TMS (MEPTMS) and to cervical electrical stimulation (MEPCES) were recorded bilaterally. Initially, the first negative peak of the MEPTMS was identified as a cortical component because it disappeared after decortication in three animals. Subsequently, we studied the effects of 2 h of electrical stimulation of one sciatic nerve on the cortical component of the MEPTMS, i.e., on motor cortex excitability. After stimulation, its amplitude increased by 117±45% (P<0.01) in the stimulated limb. A significantly smaller effect was found in the unstimulated limb (P<0.02) and no effect was observed in unstimulated control animals. The subcortically evoked MEPCES were not affected by stimulation. It is concluded that somatosensory input increases motor excitability in rat. This increase outlasts the stimulation period and is mediated by supraspinal structures, likely motor cortex. Modulation of motor cortex excitability by somatosensory input may play a role in motor learning and recovery from lesion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Luft, A.R., Kaelin-Lang, A., Hauser, TK. et al. Modulation of rodent cortical motor excitability by somatosensory input. Exp Brain Res 142, 562–569 (2002). https://doi.org/10.1007/s00221-001-0952-1

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00221-001-0952-1

Navigation