In vitro and in vivo satietogenic effect of yeast extracts and control of food intake in rats

  • Lucie Catiau
  • Naima Nedjar-Arroume
  • Didier Guillochon
  • Rozenn Ravallec
Original Paper


Yeast extracts, by their nutritional characteristics, have a high potential as a source of biologically active molecules and functional food ingredients. In this work, in vitro and in vivo satietogenic effect of yeast extracts was examined. The in vitro results obtained for the first time showed that a yeast extract strongly stimulated the secretion of cholecystokinin (CCK) from endocrine STC-1 cells. The effects obtained with this yeast extract were compared to those obtained with other food products known for their potential involvement in satiety (milk proteins, soybean). This yeast extract showed a stronger ability to stimulate CCK secretion than all other products tested. Lack of toxicity of this yeast extract was demonstrated through cell proliferation assays. In vivo, the tests in rats confirmed the satietogenic potential of this yeast extract, particularly in terms of food intake and weight loss, but also for hormone levels.


Yeast extract Cholecystokinin Enteroendocrine STC-1 cells Bioactive molecules In vivo Rats 


  1. 1.
    Arora S, Anubhuti (2006) Role of neuropeptides in appetite regulation and obesity—a review. Neuropeptides 40(6):375–401Google Scholar
  2. 2.
    Baile CA, McLaughlin CL, Della-Fera MA (1986) Role of cholecystokinin and opioid peptides in control of food intake. Physiol Rev 66(1):172–234Google Scholar
  3. 3.
    Bailey AR, Von Englehardt N, Leng G, Smith RG, Dickson SL (2000) Growth hormone secretagogue activation of the arcuate nucleus and brainstern occurs via a non-noradrenergic pathway. Neuroendocrinology 12(3):191–197Google Scholar
  4. 4.
    Cheung CC, Clifton DK, Steiner RA (1997) Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138(10):4489–4492CrossRefGoogle Scholar
  5. 5.
    Cordier-Bussat M, Bernard C, Haouche S, Roche C, Abello J, Chayvialle JA, Cuber JC (1997) Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1. Endocrinology 138(3):1137–1144CrossRefGoogle Scholar
  6. 6.
    Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50(8):1714–1719CrossRefGoogle Scholar
  7. 7.
    Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141(11):4255–4261CrossRefGoogle Scholar
  8. 8.
    El-Refai AH, El-Kady IA (1968) Sterol production of yeast strains. Zeitschrift für allgemeine Mikrobiologie 8(5):355–360CrossRefGoogle Scholar
  9. 9.
    Faipoux R, Tomé D, Bensaid A, Morens C, Oriol E, Bonnano LM, Fromentin G (2006) Yeast proteins enhance satiety in rats. J Nutr 136(9):2350–2356Google Scholar
  10. 10.
    Foltz M, Ansems P, Schwarz J, Tasker MC, Lourbakos A, Gerhardt CC (2008) Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonists of the CCK1 receptor. J Agric Food Chem 56(3):837–843CrossRefGoogle Scholar
  11. 11.
    Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1(12):1311–1314CrossRefGoogle Scholar
  12. 12.
    Jonson L, Bundgaard JR, Johnsen AH, Rourke IJ (1999) Identification and expression of gastrin and cholecystokinin mRNAs from the turtle, Pseudemys scripta: evidence of tissue-specific tyrosyl sulfation(1). Biochim Biophys Acta 1435(1–2):84–93CrossRefGoogle Scholar
  13. 13.
    Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762):656–660CrossRefGoogle Scholar
  14. 14.
    Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443(7109):289–295CrossRefGoogle Scholar
  15. 15.
    Nedjar-Arroume N, Duvois-Delval V, Adje EY, Krier F, Mary P, Kouach M, Briand G, Guillochon D (2008) Bovine hemoglobin: an attractive source of antibacterial peptides. Peptides 29(6):969–977CrossRefGoogle Scholar
  16. 16.
    Némoz-Gaillard E, Bernard C, Abello J, Cordier-Bussat M, Chayvialle JA, Cuber JC (1998) Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. Endocrinology 139(3):932–938CrossRefGoogle Scholar
  17. 17.
    Powley TL, Phillips RJ (2004) Gastric satiation is volumetric, intestinal satiation is nutritive. Physiol Behav 82(1):69–74CrossRefGoogle Scholar
  18. 18.
    Rindi G, Grant SG, Yiangou Y, Ghatei MA, Bloom SR, Bautch VL, Solcia E, Polak JM (1990) Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol 136(6):1349–1363Google Scholar
  19. 19.
    Sabry SA, El-Refai AH, Gamati SY (1989) Production of riboflavin (vitamin B2) by hydrocarbon-utilizing yeasts. Microbiologia 5(1):45–52Google Scholar
  20. 20.
    Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP (1992) Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608–3616CrossRefGoogle Scholar
  21. 21.
    Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2003) Central nervous system control of food intake. Nature 404(6778):661–671Google Scholar
  22. 22.
    Sufian MK, Hira T, Miyashita K, Nishi T, Asano K, Hara H (2006) Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats. Biosci Biotechnol Biochem 70(8):1869–1874CrossRefGoogle Scholar
  23. 23.
    Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407(6806):908–913Google Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Lucie Catiau
    • 1
  • Naima Nedjar-Arroume
    • 1
  • Didier Guillochon
    • 1
  • Rozenn Ravallec
    • 1
  1. 1.ProBioGEM, IUT A—Polytech’LilleVilleneuve d’Ascq cedexFrance

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