Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed a diet containing cholesterol

Abstract

Coriander (Coriandrum sativum L.) seed oil (COR) is a promising oil with high levels of bioactive compounds. Very little information, however, is available on the effect of administration of COR on different aspects of plasma lipid profile in experimental animals. In view of the important implications, the effect of administration of COR and oil blend [a mixture of soybean oil, coriander oil and sunflower oil (4:2:4, w/w/w; Blend)] on the profile of plasma lipids was investigated in 24 male albino rats placed on a cholesterol-rich (1%) basal diet as compared to rats on a cholesterol-free basal diet. Coriander seed oil and Blend were analyzed for composition of fatty acid, sterol and tocopherol. The levels of bioactive compounds (sterols and tocopherols) were higher in COR than in the Blend. In addition, the antiradical potential of COR and Blend was measured and the results showed that COR had stronger radical scavenging activity than Blend. In the biological experiment, rats were divided into four diet groups. The negative control group (control) consumed the basal diet (BD) only, which contained wheat starch, casein and cellulose, as well as mineral and vitamin mixtures. To the BD were added 1 g/100 g cholesterol (Chol/group), or both (Chol/COR group) and (Chol/Blend group). The groups did not differ before the experiment, which lasted 60 days. Plasma total lipids (TL), triacylglycerols (TAG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were measured at day 15, 30, 45 and 60 during the experiment period. Generally, COR and Blend-supplemented diets decreased the levels of TL, TC, TAG and LDL-C in plasma. In addition, significant increase in the levels of HDL-C was observed for Chol/COR and Chol/Blend groups. The results demonstrated that COR, and to a relatively lesser degree Blend, have hypocholesterolemic properties in rats fed a cholesterol-rich diet.

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Abbreviations

COR:

Coriander seed oil

Blend:

A mixture of soybean oil, coriander oil and sunflower oil (4:2:4, w/w/w)

HDL-C:

HDL-cholesterol

LDL-C:

LDL-cholesterol

TC:

Total cholesterol

TAG:

Triacylglycerols

TL:

Total lipids

BD:

Basal diet

DPPH:

1,1-Diphenyl-2-picrylhydrazyl

Chol:

Cholesterol

References

  1. 1.

    Sharma RD, Raghuram TC (1991) Phytother Res 30:145–147

    Article  Google Scholar 

  2. 2.

    Ravi R, Prakash M, Keshava Bhat K (2007) Eur Food Res Technol 225:367–374

    Article  CAS  Google Scholar 

  3. 3.

    Meier zu Beerentrup H, Röbbelen G (1987) Fat Sci Technol 89:227–230

    CAS  Google Scholar 

  4. 4.

    Ramadan MF, Moersel J-T (2002) Eur Food Res Technol 215:204–209

    Article  CAS  Google Scholar 

  5. 5.

    Eierdanz H, Hirsinger F (1990) Fat Sci Technol 92:463–467

    CAS  Google Scholar 

  6. 6.

    Princen LH, Rothfus JA (1984) J Am Oil Chem Soc 61:281–289

    Article  CAS  Google Scholar 

  7. 7.

    Ramadan MF, Moersel J-T (2002) Eur Food Res Technol 214:521–527

    Article  CAS  Google Scholar 

  8. 8.

    Ramadan MF, Moersel J-T (2003) Food Chem 80:197–204

    Article  CAS  Google Scholar 

  9. 9.

    Ramadan MF, Kroh LW, Moersel J-T (2003) J Agric Food Chem 51:6961–6969

    Article  CAS  Google Scholar 

  10. 10.

    Ramadan MF, Moersel J-T (2004) Euro J Lipid Sci Technol 106:35–43

    Article  CAS  Google Scholar 

  11. 11.

    Ramadan MF, Moersel J-T (2006) J Food Comp Anal 19:838–842

    Article  CAS  Google Scholar 

  12. 12.

    Lewis YS (1986) Food Policy Indian Food Ind 5:101–107

    Google Scholar 

  13. 13.

    Heimermann HW, Holman RT, Gordon DT, Kowalyshyn DE, Jensen RG (1973) Lipids 8:45–46

    Article  CAS  Google Scholar 

  14. 14.

    Seher A, Fiebig HJ (1983) Fette Seifen Anstrichm 85:333–338

    Article  CAS  Google Scholar 

  15. 15.

    Weber N, Richter KD, Schulte E, Mukherjee KD (1995) J Nutr 125:1563–1568

    CAS  Google Scholar 

  16. 16.

    Weber N, Vosmann K, Brühl L, Mukherjee KD (1997) Nutr Res 17:89–98

    Article  CAS  Google Scholar 

  17. 17.

    Weber N, KiewittI I, Mukhejee KD (1999) Nutr Res 19:997–1007

    Article  CAS  Google Scholar 

  18. 18.

    Grundy SM (1986) New Eng J Med 314:745–748

    CAS  Article  Google Scholar 

  19. 19.

    Grundy SM, Florentin N, Nix D, Whelan MF (1988) Am J Clin Nutr 47:965–969

    CAS  Google Scholar 

  20. 20.

    Mattson FH, Grundy SM (1985) J Lipid Res 26:194–202

    CAS  Google Scholar 

  21. 21.

    Mensink RP, Katan MB (1987) Lancet 1:122–124

    Article  CAS  Google Scholar 

  22. 22.

    Mensink RP, Katan MB (1989) New Eng J Med 321:436–441

    CAS  Article  Google Scholar 

  23. 23.

    Mensink RP, de-Groot MJM, Van den Broeke LT, Severijnen-Nobels AP, Demacker PNM, Katan MB (1989) Metabolism 38:172–178

    Article  CAS  Google Scholar 

  24. 24.

    Wahrburg U, Martin H, Sandkamp M, Schulte H, Assmann G (1992) Am J Clin Nutr 56:678–683

    CAS  Google Scholar 

  25. 25.

    Hoy CE, Holmer G (1981) Lipids 16:102–108

    Article  CAS  Google Scholar 

  26. 26.

    Mohrhauer H, Rahm JJ, Seufert J, Holman RT (1967) J Nutr 91:521–527

    CAS  Google Scholar 

  27. 27.

    Arens M, Schulte E, Weber K (1994) Fat Sci Technol 96:67–68

    Google Scholar 

  28. 28.

    Coudon B, Bouige D (1973) Ann Biol Clin (Paris) 31:3–7

    CAS  Google Scholar 

  29. 29.

    Richmond W (1973) Clin Chem 19:1350–1356

    CAS  Google Scholar 

  30. 30.

    Demacker AG, Hijmans BJ, Brenninkmeijer AP, Jansen JS, van’t Laar A (1984) Clin Chem 30:1797–1800

    CAS  Google Scholar 

  31. 31.

    Fossati P, Prencipe L (1982) Clin Chem 28:2077–2080

    CAS  Google Scholar 

  32. 32.

    Murphy DJ (1994) In: Murphy DJ (ed) Designer oil crops. Breeding, processing and biotechnology, VCH Verlagsgesellschaft, Weinheim, pp 5–71

  33. 33.

    Subbaram MR, Youngs GG (1967) J Am Oil Chem Soc 44:425–428

    Article  CAS  Google Scholar 

  34. 34.

    Finley JW, Shahidi F (2001) The chemistry, processing and health benefits of highly unsaturated fatty acids: an overview. In: John WJ, Shahidi F (eds) Omega-3 fatty acids, chemistry, nutrition and health effects. American Chemical Society, Washington DC, pp 1–13

    Google Scholar 

  35. 35.

    Riemersma RA (2001) Euro J Lipid Sci Technol 103:372–373

    Article  CAS  Google Scholar 

  36. 36.

    Yang B, Karlsson RM, Oksman PH, Kallio HP (2001) J Agric Food Chem 49:5620–5629

    Article  CAS  Google Scholar 

  37. 37.

    Ntanios F (2001) Euro J Lipid Sci Technol 103:102–106

    Article  CAS  Google Scholar 

  38. 38.

    Sokol RJ (1996) Vitamin E. In: Ziegler EE, Filer LJ (eds) Present knowledge in nutrition. ILSI Press, Washington DC, pp 130–136

    Google Scholar 

  39. 39.

    Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC (1993) New Eng J Med 328:1450–1456

    Article  CAS  Google Scholar 

  40. 40.

    Gey KF, Puska P, Jordan P, Moser UK (1991) Am J Clin Nutr 53:3245–3265

    Google Scholar 

  41. 41.

    Kallio H, Yang B, Peippo P, Tahvonen R, Pan R (2002) J Agric Food Chem 50:3004–3009

    Article  CAS  Google Scholar 

  42. 42.

    Kamal-Eldin A, Andersson R (1997) J Am Oil Chem Soc 74:375–380

    Article  CAS  Google Scholar 

  43. 43.

    Kamal-Eldin A, Appelqvist LA (1996) Lipids 31:671–701

    Article  CAS  Google Scholar 

  44. 44.

    Schwarz K, Bertelsen G, Nissen LR, Gardner PT, Heinonen MI, Hopia A, Huynh-Ba T, Lambelet P, McPhail D, Skibsted LH, Tijburg L (2000) Eur Food Res Technol 21:319–328

    Google Scholar 

  45. 45.

    Jung U, Lee SK, Hum S, Chung GH, Chung M, Lee CH (2001) Food Sci Biotechnol 10:354–359

    Google Scholar 

  46. 46.

    Aguilera CM, Ramirez-Tortosa MC, Mesa MD, Gil A (2001) Nutr Hosp 16:78–91 (Article in Spanish)

    CAS  Google Scholar 

  47. 47.

    Sandström M, Petersen CE, Marckmann P (2000) Atherosclerosis 151:114–120

    Google Scholar 

  48. 48.

    Julius U (2003) Exp Clin Endocrinol Diabetes 111:60–65

    Article  CAS  Google Scholar 

  49. 49.

    Lichtenstein AH (2003) J Womens Health (Larchmt) 12:109–114

    Article  Google Scholar 

  50. 50.

    Sacks S, Katan M (2002) Am J Med 113:13–24

    Article  Google Scholar 

  51. 51.

    Kwiterovich PO, Coresh J, Smith HH, Bachoric PS, Derby CA, Pearson TA (1992) Am J Cardiol 69:1015–1021

    Article  Google Scholar 

  52. 52.

    Hodis HN, Mack WJ, Azen SP, Alaupovic P, Pagoda JM, La Bree L, Hemphill LC, Kramsh DM, Blankenhorn DH (1994) Circulation 90:42–49

    CAS  Google Scholar 

  53. 53.

    Faggiotto A, Ross R (1984) Arteriosclerosis 4:341–356

    CAS  Google Scholar 

  54. 54.

    Faggiotto A, Ross R, Harker L (1984) Arteriosclerosis 4:323–340

    CAS  Google Scholar 

  55. 55.

    Freedman D, Newman WI, Tracy R, Voors AE, Srinivasan SR, Webber LS, Restrepo C, Strong JP, Berenson GS (1988) Circulation 77:856–864

    CAS  Google Scholar 

  56. 56.

    Witztum JL, Steinberg D (1991) J Clin Invest 88:1785–1792

    Article  CAS  Google Scholar 

  57. 57.

    Gorinstein S, Zachwieja Z, Folta M, Barton H, Piotrowicz J, Zemser M, Weisz M, Trakhtenberg S, Martin-Belloso O (2001) J Agric Food Chem 49:952–957

    Article  CAS  Google Scholar 

  58. 58.

    Gorinstein S, Zemser M, Haruenkit R, Chuthakorn R, Martin-Belloso O, Trakhtenberg S (1988) J Nutr Biochem 10:367–371

    Article  Google Scholar 

  59. 59.

    Gorinstein S, Zemser M, Lichman I, Berebi A, Kleipfish A, Libman I, Trakhtenberg S, Caspi A (1997) J Intern Med 241:47–51

    Article  CAS  Google Scholar 

  60. 60.

    Spiller GA (1991) Cereal Foods World 36:812–814

    Google Scholar 

  61. 61.

    Mattson FH (1989) J Am Diet Assoc 89:387–391

    CAS  Google Scholar 

  62. 62.

    Truswell AS, Choudhury N (1998) Eur J Clin Nutr 52:312–315

    Article  CAS  Google Scholar 

  63. 63.

    Espin JC, Rivas CS, Wichers HJ (2001) J Agric Food Chem 48:648–656

    Article  CAS  Google Scholar 

  64. 64.

    Pellegrini N, Visioli F, Buratti S, Brighenti F (2001) J Agric Food Chem 49:2532–2538

    Article  CAS  Google Scholar 

  65. 65.

    Matsuno H, Kozawa O, Niwa M, Abe A, Takiguchi Y, Uematsu Y (2001) Lipids 36:453–460

    Article  CAS  Google Scholar 

  66. 66.

    Kempaiah RK, Srinivasan K (2002) Mol Cell Biochem 236:155–161

    Article  CAS  Google Scholar 

  67. 67.

    Visioli F, Galli C (2001) Curr Atheroscler Rep 3:64–67

    Article  CAS  Google Scholar 

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Correspondence to Mohamed Fawzy Ramadan.

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Ramadan, M.F., Amer, M.M.A. & Awad, A.E. Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed a diet containing cholesterol. Eur Food Res Technol 227, 1173–1182 (2008). https://doi.org/10.1007/s00217-008-0833-y

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Keywords

  • Coriander seed oil
  • Coriandrum sativum L.
  • Hypocholesterolemia
  • Soybean oil
  • Sunflower oil
  • Vegetable oil blends
  • Radical scavenging activity
  • Lipid profile
  • LDL-cholesterol
  • HDL-cholesterol