European Food Research and Technology

, Volume 227, Issue 4, pp 1173–1182 | Cite as

Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed a diet containing cholesterol

  • Mohamed Fawzy RamadanEmail author
  • Mohamed Mostafa Afify Amer
  • Ahmed El-Said Awad
Original Paper


Coriander (Coriandrum sativum L.) seed oil (COR) is a promising oil with high levels of bioactive compounds. Very little information, however, is available on the effect of administration of COR on different aspects of plasma lipid profile in experimental animals. In view of the important implications, the effect of administration of COR and oil blend [a mixture of soybean oil, coriander oil and sunflower oil (4:2:4, w/w/w; Blend)] on the profile of plasma lipids was investigated in 24 male albino rats placed on a cholesterol-rich (1%) basal diet as compared to rats on a cholesterol-free basal diet. Coriander seed oil and Blend were analyzed for composition of fatty acid, sterol and tocopherol. The levels of bioactive compounds (sterols and tocopherols) were higher in COR than in the Blend. In addition, the antiradical potential of COR and Blend was measured and the results showed that COR had stronger radical scavenging activity than Blend. In the biological experiment, rats were divided into four diet groups. The negative control group (control) consumed the basal diet (BD) only, which contained wheat starch, casein and cellulose, as well as mineral and vitamin mixtures. To the BD were added 1 g/100 g cholesterol (Chol/group), or both (Chol/COR group) and (Chol/Blend group). The groups did not differ before the experiment, which lasted 60 days. Plasma total lipids (TL), triacylglycerols (TAG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were measured at day 15, 30, 45 and 60 during the experiment period. Generally, COR and Blend-supplemented diets decreased the levels of TL, TC, TAG and LDL-C in plasma. In addition, significant increase in the levels of HDL-C was observed for Chol/COR and Chol/Blend groups. The results demonstrated that COR, and to a relatively lesser degree Blend, have hypocholesterolemic properties in rats fed a cholesterol-rich diet.


Coriander seed oil Coriandrum sativum L. Hypocholesterolemia Soybean oil Sunflower oil Vegetable oil blends Radical scavenging activity Lipid profile LDL-cholesterol HDL-cholesterol 



Coriander seed oil


A mixture of soybean oil, coriander oil and sunflower oil (4:2:4, w/w/w)






Total cholesterol




Total lipids


Basal diet






  1. 1.
    Sharma RD, Raghuram TC (1991) Phytother Res 30:145–147CrossRefGoogle Scholar
  2. 2.
    Ravi R, Prakash M, Keshava Bhat K (2007) Eur Food Res Technol 225:367–374CrossRefGoogle Scholar
  3. 3.
    Meier zu Beerentrup H, Röbbelen G (1987) Fat Sci Technol 89:227–230Google Scholar
  4. 4.
    Ramadan MF, Moersel J-T (2002) Eur Food Res Technol 215:204–209CrossRefGoogle Scholar
  5. 5.
    Eierdanz H, Hirsinger F (1990) Fat Sci Technol 92:463–467Google Scholar
  6. 6.
    Princen LH, Rothfus JA (1984) J Am Oil Chem Soc 61:281–289CrossRefGoogle Scholar
  7. 7.
    Ramadan MF, Moersel J-T (2002) Eur Food Res Technol 214:521–527CrossRefGoogle Scholar
  8. 8.
    Ramadan MF, Moersel J-T (2003) Food Chem 80:197–204CrossRefGoogle Scholar
  9. 9.
    Ramadan MF, Kroh LW, Moersel J-T (2003) J Agric Food Chem 51:6961–6969CrossRefGoogle Scholar
  10. 10.
    Ramadan MF, Moersel J-T (2004) Euro J Lipid Sci Technol 106:35–43CrossRefGoogle Scholar
  11. 11.
    Ramadan MF, Moersel J-T (2006) J Food Comp Anal 19:838–842CrossRefGoogle Scholar
  12. 12.
    Lewis YS (1986) Food Policy Indian Food Ind 5:101–107Google Scholar
  13. 13.
    Heimermann HW, Holman RT, Gordon DT, Kowalyshyn DE, Jensen RG (1973) Lipids 8:45–46CrossRefGoogle Scholar
  14. 14.
    Seher A, Fiebig HJ (1983) Fette Seifen Anstrichm 85:333–338CrossRefGoogle Scholar
  15. 15.
    Weber N, Richter KD, Schulte E, Mukherjee KD (1995) J Nutr 125:1563–1568Google Scholar
  16. 16.
    Weber N, Vosmann K, Brühl L, Mukherjee KD (1997) Nutr Res 17:89–98CrossRefGoogle Scholar
  17. 17.
    Weber N, KiewittI I, Mukhejee KD (1999) Nutr Res 19:997–1007CrossRefGoogle Scholar
  18. 18.
    Grundy SM (1986) New Eng J Med 314:745–748CrossRefGoogle Scholar
  19. 19.
    Grundy SM, Florentin N, Nix D, Whelan MF (1988) Am J Clin Nutr 47:965–969Google Scholar
  20. 20.
    Mattson FH, Grundy SM (1985) J Lipid Res 26:194–202Google Scholar
  21. 21.
    Mensink RP, Katan MB (1987) Lancet 1:122–124CrossRefGoogle Scholar
  22. 22.
    Mensink RP, Katan MB (1989) New Eng J Med 321:436–441CrossRefGoogle Scholar
  23. 23.
    Mensink RP, de-Groot MJM, Van den Broeke LT, Severijnen-Nobels AP, Demacker PNM, Katan MB (1989) Metabolism 38:172–178CrossRefGoogle Scholar
  24. 24.
    Wahrburg U, Martin H, Sandkamp M, Schulte H, Assmann G (1992) Am J Clin Nutr 56:678–683Google Scholar
  25. 25.
    Hoy CE, Holmer G (1981) Lipids 16:102–108CrossRefGoogle Scholar
  26. 26.
    Mohrhauer H, Rahm JJ, Seufert J, Holman RT (1967) J Nutr 91:521–527Google Scholar
  27. 27.
    Arens M, Schulte E, Weber K (1994) Fat Sci Technol 96:67–68Google Scholar
  28. 28.
    Coudon B, Bouige D (1973) Ann Biol Clin (Paris) 31:3–7Google Scholar
  29. 29.
    Richmond W (1973) Clin Chem 19:1350–1356Google Scholar
  30. 30.
    Demacker AG, Hijmans BJ, Brenninkmeijer AP, Jansen JS, van’t Laar A (1984) Clin Chem 30:1797–1800Google Scholar
  31. 31.
    Fossati P, Prencipe L (1982) Clin Chem 28:2077–2080Google Scholar
  32. 32.
    Murphy DJ (1994) In: Murphy DJ (ed) Designer oil crops. Breeding, processing and biotechnology, VCH Verlagsgesellschaft, Weinheim, pp 5–71Google Scholar
  33. 33.
    Subbaram MR, Youngs GG (1967) J Am Oil Chem Soc 44:425–428CrossRefGoogle Scholar
  34. 34.
    Finley JW, Shahidi F (2001) The chemistry, processing and health benefits of highly unsaturated fatty acids: an overview. In: John WJ, Shahidi F (eds) Omega-3 fatty acids, chemistry, nutrition and health effects. American Chemical Society, Washington DC, pp 1–13Google Scholar
  35. 35.
    Riemersma RA (2001) Euro J Lipid Sci Technol 103:372–373CrossRefGoogle Scholar
  36. 36.
    Yang B, Karlsson RM, Oksman PH, Kallio HP (2001) J Agric Food Chem 49:5620–5629CrossRefGoogle Scholar
  37. 37.
    Ntanios F (2001) Euro J Lipid Sci Technol 103:102–106CrossRefGoogle Scholar
  38. 38.
    Sokol RJ (1996) Vitamin E. In: Ziegler EE, Filer LJ (eds) Present knowledge in nutrition. ILSI Press, Washington DC, pp 130–136Google Scholar
  39. 39.
    Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC (1993) New Eng J Med 328:1450–1456CrossRefGoogle Scholar
  40. 40.
    Gey KF, Puska P, Jordan P, Moser UK (1991) Am J Clin Nutr 53:3245–3265Google Scholar
  41. 41.
    Kallio H, Yang B, Peippo P, Tahvonen R, Pan R (2002) J Agric Food Chem 50:3004–3009CrossRefGoogle Scholar
  42. 42.
    Kamal-Eldin A, Andersson R (1997) J Am Oil Chem Soc 74:375–380CrossRefGoogle Scholar
  43. 43.
    Kamal-Eldin A, Appelqvist LA (1996) Lipids 31:671–701CrossRefGoogle Scholar
  44. 44.
    Schwarz K, Bertelsen G, Nissen LR, Gardner PT, Heinonen MI, Hopia A, Huynh-Ba T, Lambelet P, McPhail D, Skibsted LH, Tijburg L (2000) Eur Food Res Technol 21:319–328Google Scholar
  45. 45.
    Jung U, Lee SK, Hum S, Chung GH, Chung M, Lee CH (2001) Food Sci Biotechnol 10:354–359Google Scholar
  46. 46.
    Aguilera CM, Ramirez-Tortosa MC, Mesa MD, Gil A (2001) Nutr Hosp 16:78–91 (Article in Spanish)Google Scholar
  47. 47.
    Sandström M, Petersen CE, Marckmann P (2000) Atherosclerosis 151:114–120Google Scholar
  48. 48.
    Julius U (2003) Exp Clin Endocrinol Diabetes 111:60–65CrossRefGoogle Scholar
  49. 49.
    Lichtenstein AH (2003) J Womens Health (Larchmt) 12:109–114CrossRefGoogle Scholar
  50. 50.
    Sacks S, Katan M (2002) Am J Med 113:13–24CrossRefGoogle Scholar
  51. 51.
    Kwiterovich PO, Coresh J, Smith HH, Bachoric PS, Derby CA, Pearson TA (1992) Am J Cardiol 69:1015–1021CrossRefGoogle Scholar
  52. 52.
    Hodis HN, Mack WJ, Azen SP, Alaupovic P, Pagoda JM, La Bree L, Hemphill LC, Kramsh DM, Blankenhorn DH (1994) Circulation 90:42–49Google Scholar
  53. 53.
    Faggiotto A, Ross R (1984) Arteriosclerosis 4:341–356Google Scholar
  54. 54.
    Faggiotto A, Ross R, Harker L (1984) Arteriosclerosis 4:323–340Google Scholar
  55. 55.
    Freedman D, Newman WI, Tracy R, Voors AE, Srinivasan SR, Webber LS, Restrepo C, Strong JP, Berenson GS (1988) Circulation 77:856–864Google Scholar
  56. 56.
    Witztum JL, Steinberg D (1991) J Clin Invest 88:1785–1792CrossRefGoogle Scholar
  57. 57.
    Gorinstein S, Zachwieja Z, Folta M, Barton H, Piotrowicz J, Zemser M, Weisz M, Trakhtenberg S, Martin-Belloso O (2001) J Agric Food Chem 49:952–957CrossRefGoogle Scholar
  58. 58.
    Gorinstein S, Zemser M, Haruenkit R, Chuthakorn R, Martin-Belloso O, Trakhtenberg S (1988) J Nutr Biochem 10:367–371CrossRefGoogle Scholar
  59. 59.
    Gorinstein S, Zemser M, Lichman I, Berebi A, Kleipfish A, Libman I, Trakhtenberg S, Caspi A (1997) J Intern Med 241:47–51CrossRefGoogle Scholar
  60. 60.
    Spiller GA (1991) Cereal Foods World 36:812–814Google Scholar
  61. 61.
    Mattson FH (1989) J Am Diet Assoc 89:387–391Google Scholar
  62. 62.
    Truswell AS, Choudhury N (1998) Eur J Clin Nutr 52:312–315CrossRefGoogle Scholar
  63. 63.
    Espin JC, Rivas CS, Wichers HJ (2001) J Agric Food Chem 48:648–656CrossRefGoogle Scholar
  64. 64.
    Pellegrini N, Visioli F, Buratti S, Brighenti F (2001) J Agric Food Chem 49:2532–2538CrossRefGoogle Scholar
  65. 65.
    Matsuno H, Kozawa O, Niwa M, Abe A, Takiguchi Y, Uematsu Y (2001) Lipids 36:453–460CrossRefGoogle Scholar
  66. 66.
    Kempaiah RK, Srinivasan K (2002) Mol Cell Biochem 236:155–161CrossRefGoogle Scholar
  67. 67.
    Visioli F, Galli C (2001) Curr Atheroscler Rep 3:64–67CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Mohamed Fawzy Ramadan
    • 1
    Email author
  • Mohamed Mostafa Afify Amer
    • 1
  • Ahmed El-Said Awad
    • 1
  1. 1.Biochemistry Department, Faculty of AgricultureZagazig UniversityZagazigEgypt

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