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Radical scavenging activity of chitooligosaccharide with different molecular weights

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Abstract

Two chitooligosaccharides, Ch1100 (average molecule weight: 1,100; average degree of polymer: 7) and Ch500 (average molecule weight: 500; average degree of polymer: 3), were obtained by partial hydrolysis of chitosan. Their antioxidant activities were investigated with scavenging activity of chitooligosaccharide against superoxide radical using phenazin methosulphate (PMS)–β-nicotinamide adenine dinucleotide (NADH)–nitroblue tetrazolium (NBT) system, scavenging activity of chitooligosaccharide against carcinogen-induced active oxygen species and scavenging activity of chitooligosaccharide against hydrogen peroxide released from polymorphonuclear leukocytes stimulated by phorbol-12-myristate-13-acetate (PMA). By the aforementioned three measurements, the radical scavenging activity (Inhibition%) of Ch1100 was determined to 54.8, 35.3 and 38.9%, respectively, at the concentration of 100 μmol/L, while that of Ch500 was 40.1, 13.9 and 18.2%, respectively, at the same concentration. These results clearly suggest that Ch1100 is a potent radical scavenger, which has the high radical scavenging activity.

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Acknowledgement

This research was financially supported by Jiangsu Province Education Commission Natural Science Foundation, People's Republic of China (Grant Number: 03KJB3101110)

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Authors and Affiliations

  1. Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, People's Republic of China

    Yumin Yang & Xingxing Gu

  2. Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330006, People's Republic of China

    Rengeng Shu

  3. School of Chemistry and Chemical Technology, Nantong, People's Republic of China

    Jian Shao

  4. School of Public Health Nantong, Jiangsu, 226001, People's Republic of China

    Guangfei Xu

Authors
  1. Yumin Yang
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  2. Rengeng Shu
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  3. Jian Shao
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  4. Guangfei Xu
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  5. Xingxing Gu
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Correspondence to Xingxing Gu.

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Yang, Y., Shu, R., Shao, J. et al. Radical scavenging activity of chitooligosaccharide with different molecular weights. Eur Food Res Technol 222, 36–40 (2006). https://doi.org/10.1007/s00217-005-0028-8

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  • DOI: https://doi.org/10.1007/s00217-005-0028-8

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