Fresenius' Journal of Analytical Chemistry

, Volume 369, Issue 5, pp 397–402 | Cite as

Selectivity and specificity in analytical chemistry. General considerations and attempt of a definition and quantification

  • Klaus Danzer
Discussion paper


Selectivity and specificity are performance characteristics of analytical methods which are frequently used in analytical literature. In general, the terms are applied verbally and a quantification of selectivity and specificity is given rarely. Excepted are methods like chromatography and ISE sensoring which use individual quantities such as selectivity coefficients, indices and other parameters to characterize analytical procedures and systems. Here a proposal is given to characterize selectivity and specificity quantitatively by relative values in a range of 0 to 1 expressing so a certain degree of selectivity and specificity. By examples it will be shown that the derived quantities characterize analytical methods and problems in a plausible way.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Klaus Danzer
    • 1
  1. 1.Friedrich Schiller University of Jena, Institute of Inorganic and Analytical Chemistry, Lessingstr. 8, 07743 Jena, Germany e-mail: klaus.danzer@uni-jena.deDE

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