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Synergistically enhancing electrocatalysis and non-enzymatic sensing for glucose by iridium single-atom/nickel oxide/N-doped graphene

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Abstract

The development of novel catalyst with high catalytic activity is important for electrochemical non-enzymatic glucose sensing. Here, iridium single-atom/nickel oxide nanoparticle/N-doped graphene nanosheet (Ir1/NiO/NG) with the loading of 1.13 wt% Ir was successfully synthesized for constructing electrochemical non-enzymatic glucose sensor for the first time. The morphology and structure of Ir1/NiO/NG were characterized by XRD, SEM, TEM, HRTEM, and XPS, and the presence of Ir SAs was confirmed by AC-HAADF-STEM. The Ir1/NiO/NG shows 65 mV lower oxidation potential and 3.3 times higher response current than Ni(OH)2/NG. In addition, Ir1/NiO/NG exhibits high sensitivity (70.09 μA mM−1 cm−2), excellent selectivity, low detection limit (2.00 μM), and great stability (91.53% current remaining after 21 days) for electrochemical non-enzymatic glucose sensing. The outstanding catalytic and sensing performance of Ir1/NiO/NG is mainly attributed to synergistic effect of Ir SAs, NiO nanoparticles, and highly conductive NG, which modulate the electronic and geometric structure of Ir1/NiO/NG. This work shows the promising potential of SACs in electrochemical sensing.

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Funding

Changsheng Shan acknowledges the National Natural Science Foundation of China (grant Nos. 22274036 and 21874031) and “Chu-Tian Scholar” Program of Hubei Province. Yuanmeng Zhao thanks the National Natural Science Foundation of China (grant No. 22302059).

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Authors and Affiliations

  1. Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China

    Yaojiang Zhou, Wen Wei, Wenli Lei, Fudong Li, Jiaxi Shu, Zixuan Deng, Wenyu Hui, Yuanmeng Zhao & Changsheng Shan

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  1. Yaojiang Zhou
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  2. Wen Wei
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  3. Wenli Lei
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Contributions

Yaojiang Zhou: methodology, conceptualization, investigation, formal analysis, investigation, and writing, original draft. Wen Wei: methodology and investigation. Wenli Lei: methodology and investigation. Fudong Li: methodology and investigation. Jiaxi Shu: methodology and investigation. Zixuan Deng: methodology and investigation. Wenyu Hui: methodology and investigation. Yuanmeng Zhao: resources, discussion, and writing, review and editing. Changsheng Shan: methodology, conceptualization, resources, supervision, and writing, review and editing.

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Correspondence to Changsheng Shan.

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Published in the topical collection featuring Nanozymes with guest editors Vipul Bansal, Sudipta Seal, and Hui Wei.

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Zhou, Y., Wei, W., Lei, W. et al. Synergistically enhancing electrocatalysis and non-enzymatic sensing for glucose by iridium single-atom/nickel oxide/N-doped graphene. Anal Bioanal Chem (2024). https://doi.org/10.1007/s00216-024-05226-8

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