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A ZnIn2S4/Ag2CO3 Z-scheme heterostructure-based photoelectrochemical biosensor for neuron-specific enolase

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Abstract

An efficient photo-to-electrical signal is pivotal to photoelectrochemical (PEC) biosensors. In our work, a novel PEC biosensor was fabricated for the detection of neuron-specific enolase (NSE) based on a ZnIn2S4/Ag2CO3 Z-scheme heterostructure. Due to the overlapping band potentials of the ZnIn2S4 and Ag2CO3, the formed Z-scheme heterostructure can promote the charge separation and photoelectric conversion efficiency. And the concomitant Ag nanoparticles in Ag2CO3 provided multiple functions to enhance the PEC response of the Z-scheme heterostructure. It acts not only as a bridge for the transfer of carriers between ZnIn2S4 and Ag2CO3, promoting the constructed Z-scheme heterostructure, but also as electron mediators to accelerate the transfer of photogenerated carriers and improve the capture of visible light of the Z-scheme heterostructure by surface plasmon resonance (SPR). Compared with single Ag2CO3 and ZnIn2S4, the photocurrent of the designed Z-scheme heterostructure increased more than 20 and 60 times respectively. The fabricated PEC biosensor based on a ZnIn2S4/Ag2CO3 Z-scheme heterostructure exhibits sensitive detection to NSE, and presents a linear range of 50 fg·mL−1 ~ 200 ng·mL−1 with a limit of detection of 4.86 fg·mL−1. The proposed PEC biosensor provides a potential approach for clinical diagnosis.

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Acknowledgements

This work was supported by the Natural Science Foundation of Shandong Province (No. ZR2022QB151, ZR2021MB048) and the National Natural Science Foundation of China (No. 22274062).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, People’s Republic of China

    Jun Li, Shanghua Liu, Hui Dong, Yueyuan Li, Qing Liu, Shujun Wang, Ping Wang, Yang Li & Yueyun Li

  2. Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People’s Republic of China

    Qin Wei

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  1. Jun Li
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Li, J., Liu, S., Dong, H. et al. A ZnIn2S4/Ag2CO3 Z-scheme heterostructure-based photoelectrochemical biosensor for neuron-specific enolase. Anal Bioanal Chem 415, 5551–5562 (2023). https://doi.org/10.1007/s00216-023-04830-4

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