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Advances in wearable electrochemical antibody-based sensors for cortisol sensing

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Abstract

Cortisol is a crucial hormone involving many physiological processes. Hence, cortisol detection is essential. This review highlights the key progress made on wearable electrochemical sensors using antibodies. It covers the design, principle, and electroanalytical methodology for detecting cortisol noninvasively. This article also analyzes and collects the analytical performances of electrochemical cortisol sensors. The development of these sensors continues to face challenges such as biofouling, sample management, sensitivity, flexibility, stability, and recognition layer performance. It is also necessary to develop a sensitive electrode and material. This article also presents potential strategies for designing antibody electrodes and provides examples of sensing systems. Additionally, it discusses the challenges in translating research into practical applications.

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Acknowledgements

We would like to thank the Talent Management Project of Prince of Songkla University and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Ministry of Higher Education, Science, Research, and Innovation (MHESI).

Funding

I.J. received support from the National Research Council of Thailand (NRCT, Grant No. N41A640129), Prince of Songkla University, Hat Yai, Thailand.

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Authors and Affiliations

  1. Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Suntisak Khumngern & Itthipon Jeerapan

  2. Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Suntisak Khumngern & Itthipon Jeerapan

  3. Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand

    Itthipon Jeerapan

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  1. Suntisak Khumngern
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Correspondence to Itthipon Jeerapan.

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Published in the topical collection Young Investigators in (Bio-)Analytical Chemistry 2023 with guest editors Zhi-Yuan Gu, Beatriz Jurado-Sánchez, Thomas H. Linz, Leandro Wang Hantao, Nongnoot Wongkaew, and Peng Wu.

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Khumngern, S., Jeerapan, I. Advances in wearable electrochemical antibody-based sensors for cortisol sensing. Anal Bioanal Chem 415, 3863–3877 (2023). https://doi.org/10.1007/s00216-023-04577-y

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