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Construction of cellulose-based highly sensitive extended-gate field effect chiral sensor

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Abstract

Chiral recognition is an emerging field of modern chemical analysis, and the development of health-related fields depends on the production of enantiomers. Cellulose is a kind of natural polymer material with certain chiral recognition ability. Limited by the chiral recognition ability of natural cellulose itself, more cellulose derivatives have been gradually developed for chiral recognition and separation. Based on the difference in action between cellulose derivatives and enantiomers, this work synthesized cellulose-tris(4-methylphenylcarbamate) (CMPC) chiral recognition mediators and a CMPC-functionalized extended-gate organic field effect transistor (EG-OFET) was constructed for the first time. Three chiral molecules were selected as model analytes to evaluate the enantiomeric recognition ability of the platform, including threonine (Thr), 2-chloromandelic acid (CA), and 1,2-diphenylethylenediamine (DPEA). The detection limit for 1,2-diphenylethylenediamine (DPEA) is down to 10−13 M. Through the amplification effect of the EG-OFET platform, the difference in the interaction between CMPC and three chiral molecules with different structures is converted into a current signal output. At the same time, the enantiomer discrimination mechanism of CMPC was further studied by means of spectroscopy and nuclear magnetic resonance.

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Funding

This work was financially funded by the National Key R&D Program of China (No. 2019YFC1905500), the National Natural Science Foundation of China (Nos. 21922409, 21976131), and the Tianjin Research Program of Application Foundation and Advanced Technology (No. 18JCZDJC37500).

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Authors and Affiliations

  1. School of Science, Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin, 300072, China

    Jing-Jing Zhang, Si-Ying Wang & Yong Wang

  2. School of Chemical Engineering and Technology, Key Laboratory of Applied Physical Chemistry of Qinghai Province, Qinghai Minzu University, Xining, 810007, China

    Jing-Jing Zhang & Hai-Chao Li

  3. School of Science, Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Tianjin University, Tianjin, 300072, China

    Hai-Tao Dai

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  1. Jing-Jing Zhang
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  5. Yong Wang
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Correspondence to Hai-Tao Dai or Yong Wang.

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Published in the topical collection Young Investigators in (Bio-)Analytical Chemistry 2023 with guest editors Zhi-Yuan Gu, Beatriz Jurado-Sánchez, Thomas H. Linz, Leandro Wang Hantao, Nongnoot Wongkaew, and Peng Wu.

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Zhang, JJ., Wang, SY., Dai, HT. et al. Construction of cellulose-based highly sensitive extended-gate field effect chiral sensor. Anal Bioanal Chem 415, 4245–4254 (2023). https://doi.org/10.1007/s00216-022-04306-x

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  • DOI: https://doi.org/10.1007/s00216-022-04306-x

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