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Facile high-quantum-yield sulfur-quantum-dot-based photoluminescent probe for nifedipine detection

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Abstract

Monitoring of dihydropyridine drugs, such as nifedipine (NIF), has attracted considerable attention owing to the side effects arising from the consumption of such drugs. Herein, a highly sensitive and facile fluorescence-sensing platform based on a high-quantum-yield sulfur quantum dot (SQDs) probe for NIF detection is proposed. Based on the principle of the inner filter effect, the rapid detection of NIF with high sensitivity is successfully realized on the basis of the change in the fluorescence signal due to the quenching effect of NIF on SQDs. The results show a good linear relationship between the NIF concentration and fluorescence intensity within the range of 5–150 μmol/L, with a low detection limit of 1.63 μmol/L (S/N = 3). Moreover, because no surface modification or establishment of any coupling between the receptor and the fluorophore is necessary, this approach provides considerable flexibility and simplicity for the construction of a fluorescence sensor and substantially reduces the detection time. A systematic investigation was conducted to verify the applicability of this method for the analysis of pharmaceutical components in NIF tablets. This study not only promotes the design and development of a fluorescence analysis platform for NIF detection, but also facilitates the fabrication of novel SQD-based fluorescence-sensing systems for the molecular detection of drugs.

Graphical abstract

Proposal for a facile nifedipine assay method based on the inner filter effect of nifedipine to high-quantum-yield sulfur quantum dots, and realizing nifedipine detection in tablets and human urine samples.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (21874020), the National Science Foundation for Distinguished Young Scholars of Fujian Province (2020J06019), Program for Fujian Youth Talent Support Project (2019B016), and Program for Fujian Top-Notch Innovative Personnel (Fujian Commission Talent [2018] no. 5).

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Author notes

  1. Yilun Sheng and Zhongnan Huang contributed equally to this work.

Authors and Affiliations

  1. Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350108, China

    Yilun Sheng, Zhongnan Huang, Yaling Chen, Xiaoyun Guo, Huaping Peng & Wei Chen

  2. School of Pharmacy, China Medical University, Shenyang, 110122, China

    Lan Chen

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  1. Yilun Sheng
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  2. Zhongnan Huang
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  4. Xiaoyun Guo
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  5. Lan Chen
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  6. Huaping Peng
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  7. Wei Chen
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Correspondence to Huaping Peng or Wei Chen.

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The authors declare no competing interests.

Urine samples in this study were obtained from one healthy adult volunteer. This study was approved by the Institutional Ethics Committee of Fujian Medical University, and experiments with real samples were performed in accordance with ethical standards. Informed consent was obtained from the participant in the study.

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Sheng, Y., Huang, Z., Chen, Y. et al. Facile high-quantum-yield sulfur-quantum-dot-based photoluminescent probe for nifedipine detection. Anal Bioanal Chem 414, 7675–7681 (2022). https://doi.org/10.1007/s00216-022-04297-9

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