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BODIPY-based fluorescent chemosensor for phosgene detection: confocal imaging of nasal mucosa and lung samples from mouse exposed to phosgene

Analytical and Bioanalytical Chemistry volume 414, pages 4953–4962 (2022)Cite this article

Abstract

The improper use of phosgene, either as a chemical warfare agent or a leak during chemical production, causes significant risks to human life and property. Therefore, it is particularly important to develop a rapid and highly selective method for the detection of phosgene. In this article, a highly selective fluorescent sensor ONB with a BODIPY unit as a fluorophore and o-aminophenol as a reactive site was constructed for the selective and rapid detection of phosgene in solution. The ONB-containing nanofibers were sprayed onto a non-woven fabric by electrostatic spinning and cut into test films, which can be used well for the detection of gaseous phosgene. While, there were no reported bio-imaging applications for phosgene detection. In this work, nasal mucosa and lung samples from the mice exposed to gaseous phosgene after dropping the ONB solution through the nasal cavity achieved bio-imaging applications successfully.

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Funding

This work was supported by Xinxiang City Foundation (NO. GG2021009).

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Authors and Affiliations

  1. School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People’s Republic of China

    Ying-Ying Kong

  2. School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, People’s Republic of China

    Tang-Qiang Sun, Miao-Miao Yu & Hong-Cheng Xia

Authors
  1. Ying-Ying Kong
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  2. Tang-Qiang Sun
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  3. Miao-Miao Yu
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  4. Hong-Cheng Xia
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Correspondence to Hong-Cheng Xia.

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The study was approved by the Committee of Xinxiang Medical University.

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Kong, YY., Sun, TQ., Yu, MM. et al. BODIPY-based fluorescent chemosensor for phosgene detection: confocal imaging of nasal mucosa and lung samples from mouse exposed to phosgene. Anal Bioanal Chem 414, 4953–4962 (2022). https://doi.org/10.1007/s00216-022-04120-5

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  • DOI: https://doi.org/10.1007/s00216-022-04120-5

Keywords

  • Phosgene
  • BODIPY
  • Electrostatic spinning
  • Non-woven fabric
  • Biological imaging