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Amplified electrochemical determination of niclosamide in food based on carbon nanohorn@MWCNT composite

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Abstract

In this work, carbon nanohorn (CNH)–decorated multi-walled carbon nanotube (MWCNT) (CNH@MWCNT) composite was prepared and used to modify glass carbon electrode (GCE) as sensitive electrochemical sensor for niclosamide (NA) determination. Herein, the decoration of CNHs induces higher dispersibility for MWCNTs, and endows the composite with better conductivity, larger surface area, and higher catalytic activity, which leads to significantly enhanced electrochemical behavior toward NA oxidation. The parameters such as mass ratios of CNHs and MWCHTs, the amount of composite materials, the accumulation time, and the solution pH are systematically optimized. Under optimized conditions, the developed electrochemical sensor exhibits a low detection limit of 2.0 nM with a wide linear range of 7.0 nM–10.0 µM and high anti-interference ability. In addition, the sensor displays good stability, repeatability, and reproducibility. The feasibility of the assay was verified by testing NA in brown rice and rice field water samples.

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Funding

We received financial support for this work from the National Natural Science Foundation of China ( 51862014, 22064010, and 51762020), the Natural Science Foundation of Jiangxi Province (20202ACBL213009 and 20212BAB203019), the Open Project of Engineering Center of Jiangxi University for Fine Chemicals (No. KFGJ18018), and the Jiangxi Provincial Key Laboratory of Drug Design and Evaluation (20171BCD40015).

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Authors and Affiliations

  1. Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, Engineering Center of Jiangxi University for Fine Chemicals, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, People’s Republic of China

    Min Shi, Shuya Xue, Jingkun Xu, Shuxian Chen & Xuemin Duan

  2. Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Science, Jiangxi Agricultural University, Nanchang, 330045, People’s Republic of China

    Min Shi, Jin Zou, Yansha Gao, Shuwu Liu & Limin Lu

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  1. Min Shi
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  2. Shuya Xue
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  3. Jingkun Xu
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  5. Jin Zou
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Correspondence to Xuemin Duan or Limin Lu.

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Shi, M., Xue, S., Xu, J. et al. Amplified electrochemical determination of niclosamide in food based on carbon nanohorn@MWCNT composite. Anal Bioanal Chem 414, 4119–4127 (2022). https://doi.org/10.1007/s00216-022-04060-0

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  • DOI: https://doi.org/10.1007/s00216-022-04060-0

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