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PtNPs-GNPs-MWCNTs-β-CD nanocomposite modified glassy carbon electrode for sensitive electrochemical detection of folic acid

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Abstract

A novel electrochemical sensor, platinum nanoparticles/graphene nanoplatelets/multi-walled carbon nanotubes/β-cyclodextrin composite (PtNPs-GNPs-MWCNTs-β-CD) modified carbon glass electrode (GCE), was fabricated and used for the sensitive detection of folic acid (FA). The PtNPs-GNPs-MWCNTs-β-CD nanocomposite was easily prepared with an ultrasound-assisted assembly method, and it was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The electrochemical behavior of FA at PtNPs-GNPs-MWCNTs-β-CD/GCE was investigated in detail. Some key experimental parameters such as pH, amount of PtNPs-GNPs-MWCNTs-β-CD composite, and scan rate were optimized. A good linear relationship (R2 = 0.9942) between peak current of cyclic voltammetry (CV) and FA concentration in the range 0.02–0.50 mmol L−1 was observed at PtNPs-GNPs-MWCNTs-β-CD/GCE. The detection limit was 0.48 μmol L−1 (signal-to-noise ratio = 3). A recovery of 97.55–102.96% was obtained for the determination of FA in FA pills (containing 0.4 mg FA per pill) at PtNPs-GNPs-MWCNTs-β-CD/GCE, indicating that the modified electrode possessed relatively high sensitivity and stability for the determination of FA in real samples.

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Acknowledgments

The authors are grateful for financial support from National Natural Science Foundation of China (Grant No. 51674292) and Provincial Natural Science Foundation of Hunan (Grant No. 2016JJ1023).

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  1. Meng-Meng Yuan and Jiao Zou contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, China

    Meng-Meng Yuan, Jiao Zou, Zhao-Ning Huang & Jin-Gang Yu

  2. School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China

    Dong-Ming Peng

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Yuan, MM., Zou, J., Huang, ZN. et al. PtNPs-GNPs-MWCNTs-β-CD nanocomposite modified glassy carbon electrode for sensitive electrochemical detection of folic acid. Anal Bioanal Chem 412, 2551–2564 (2020). https://doi.org/10.1007/s00216-020-02488-w

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