Dopamine homeostasis is an important clinical diagnostic index, because an abnormal level in the human body is closely related to certain serious diseases. Herein, a novel electrochemical sensing platform based on gold nanobipyramid/multi-walled carbon nanotube hybrids (AuNBP/MWCNTs) is developed to detect dopamine in human fluids. Using field emission scanning electron microscopy, it is observed that AuNBPs of about 60 nm with two pyramids are well dispersed on the surface of MWCNTs. Energy-dispersive X-ray spectrometry, X-ray diffraction and X-ray photoelectron spectroscopy confirm that AuNBPs are self-assembled onto the surface of MWCNTs to form the hybrids. Cyclic voltammetry reveals that the AuNBP/MWCNTs exhibit good electrocatalytic activity toward dopamine oxidation owing to the synergistic effects of AuNBPs and MWCNTs. In addition, both cyclic voltammetry and differential pulse voltammetry display three well-resolved and distinct oxidation peaks on the AuNBP/MWCNT-modified glassy carbon electrode. Based on AuNBP/MWCNTs, the newly developed electrochemical sensor is used to detect dopamine in the presence of ascorbic acid and uric acid over a wide linear range from 50 nM to 2.7 mM and a low detection limit of 15 nM (at S/N = 3). The electrochemical sensor can also be applied for the quantitative analysis of dopamine in real samples.
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This work was jointly supported by the National Science Foundation of China (Grants 21876125 and 21707105), Zhejiang Provincial Natural Science Foundation (LY19B070010) and Zhejiang Provincial Public Welfare Technology Application Research Project (Grants LGF19B070009 and LY19B070010).
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Cheng, J., Wang, X., Nie, T. et al. A novel electrochemical sensing platform for detection of dopamine based on gold nanobipyramid/multi-walled carbon nanotube hybrids. Anal Bioanal Chem 412, 2433–2441 (2020). https://doi.org/10.1007/s00216-020-02455-5
- Electrochemical sensor
- Gold nanobipyramids
- Multi-walled carbon nanotubes
- Ascorbic acid
- Uric acid