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A sensitive method using SPME pre-concentration for the quantification of aromatic amines in indoor air

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Abstract

Monitoring the levels of aliphatic and aromatic amines (AA) in indoor air is important to protect human health because of exposure to these compounds through diet and inhalation. A sampling and analytical method using XAD-2 cartridges and gas chromatography coupled to mass spectrometry used for assessing 25 AA in different smoking and non-smoking indoor environment was developed. After sampling and delivering 1 m3 of air (6–8 h sampling), an adsorbent was ultrasonically extracted with acetonitrile, concentrated to 1 mL and diluted in 25 mL of water (pH = 9; 5% NaCl), and then extracted for 40 min at 80 °C using a divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber and injected in a GC/MS system. With this method, 22 of the 25 AA can be analyzed with detection limits up to five times lower than that of classic liquid injection. Benzylamine, 3-aminophenol, and 4-aminophenol were not detected with the solid-phase micro-extraction (SPME) method. It can be assumed that aminophenols required a derivatization step for their analysis by GC as these molecules were not detected regardless of the injection mode used.

Analysis of aromatic amines in indoor air by SPME-GC/MS

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References

  1. Palmiotto G, Pieraccini G, Moneti G, Dolara P. Determination of the levels of aromatic amines in indoor and outdoor air in Italy. Chemosphere. 2001;43:355–61.

    Article  CAS  Google Scholar 

  2. Villa A-F, Conso F. Amines Aromatiques. EMC-Toxicologie Pathologie. 2004;1:161–77.

    Article  Google Scholar 

  3. Wilson AM, Salloway JC, Wake CP, Kelly T. Air pollution and the demand for hospital services: a review. Environ. Intern. 2004;30:1109–18.

    Article  CAS  Google Scholar 

  4. Ge X, Wexler AS, Clegg SL. Atmospheric amines—part I. A review. Atmos Environ. 2011;45:524–46.

    Article  CAS  Google Scholar 

  5. Zhu J, Aikawa B. Determination of aniline and related mono-aromatic amines in indoor air in selected Canadian residences by a modified thermal desorption GC/MS method. Environ Intern. 2004;30:135–43.

    Article  CAS  Google Scholar 

  6. Schmeltz I, Hoffman D. Nitrogen-containing compounds in tobacco and tobacco smoke. Chem Rev. 1977;77:295–331.

    Article  CAS  Google Scholar 

  7. Lores EM, Bristol DW, Moseman RF. Determination of halogenated anilines and related compounds by HPLC with electrochemical and UV detection. J Chromatogr Sci. 1978;16:358–62.

    Article  CAS  Google Scholar 

  8. Patrianakos C, Hoffman D. Chemical studies on tobacco smoke LXIV. On the analysis of a aromatic amines in cigarette smoke. J Anal Toxicol. 1979;3:150–4.

    Article  CAS  Google Scholar 

  9. Spain JC. Biodegradation of nitroaromatic compounds. Ann Rev Microbiol. 1995;49:523–55.

  10. Akyuz M. Simultaneous determination of aliphatic and aromatic amines in indoor and outdoor air samples by gas chromatography–mass spectrometry. Talanta. 2007;71:486–92.

    Article  Google Scholar 

  11. Reddy-Noone K, Jain A, Verma KK. Liquid-phase microextraction and GC for the determination of primary, secondary and tertiary aromatic amines as their iodo-derivatives. Talanta. 2007;73:684–91.

    Article  CAS  Google Scholar 

  12. Santagati NA, Bousquet E, Spadaro A, Ronsisvalle G. Analysis of aliphatic amines in air samples by HPLC with electrochemical detection. J Pharma Biomed Anal. 2002;29:1105–11.

    Article  CAS  Google Scholar 

  13. Moliner-Martinez Y, Campins-Falco P, Herraez-Hernandez R, Verdu-Andrés J. Evaluation of C18 adsorbent cartridges for sampling and derivatization of primary amines in air. Anal Chim Acta. 2004;502:235–9.

    Article  CAS  Google Scholar 

  14. Chang IH, Lee CG, Lee DS. Development of an automated method for simultaneous determination of low molecular weight aliphatic amines and ammonia in ambient air by diffusion scrubber coupled to ion chromatography. Anal Chem. 2003;75:6141–6.

    Article  CAS  Google Scholar 

  15. del Nogel Sanchez M, Perez Pavon JL, Perez Sappo C, Moreno Cordero B. A method based on microextraction by packed sorbent-programmed temperature vaporizer–fast gas chromatography–mass spectrometry for the determination of aromatic amines in environmental water samples. Anal Bioanal Chem. 2012;404:2007–15.

    Article  Google Scholar 

  16. Müller L, Fattore E, Benfenati E. Determination of aromatic amines by solid-phase microextraction and gas chromatography-mass spectrometry in water samples. J Chromatogr A. 1997;791:221–30.

    Article  Google Scholar 

  17. Arthur CL, Killam LM, Buchholz KD, Pawliszyn J, Berg JR. Automation and optimization of solid-phase microextraction. Anal Chem. 1992;64:1960–6.

    Article  CAS  Google Scholar 

  18. Buchholz KD, Pawliszyn J. Determination of phenols by solid-phase microextraction and gas chromatographic analysis. Environ Sci Technol. 1993;27:2844–8.

    Article  CAS  Google Scholar 

  19. Cardenes L, Ayala JH, Afonso AM, Gonzalez V. Solid-phase microextraction coupled with high-performance liquid chromatography for the analysis of heterocyclic aromatic amines. J Chromatogr A. 2004;1030:87–93.

    Article  CAS  Google Scholar 

  20. Kirk-Othmer RE. Aminophenols. In: Encyclopedia of chemical technology, vol. 2. Wiley-Blackwell; 2007. p. 652–3.

  21. Gorrod JW, Peyton, J III. Analytical determination of nicotine and related compounds and their metabolites. Amsterdam: Elsevier Science B.V.; 1999. p. 758.

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Funding

This study was funded by the “Alsace region” through the “GRAINE” program.

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Authors and Affiliations

  1. Institut de Chimie et Procédés pour l’Energie, l’Environnement et la Santé (ICPEES UMR 7515 CNRS, Université de Strasbourg), 1 rue Blessig, 67084, Strasbourg Cedex, France

    Vincent Lucaire, Jean-Jacques Schwartz, Ruben Ocampo-Torres & Maurice Millet

  2. Laboratoire de Chimie et de Physique, Approche Multi-Echelles des Milieux Complexes (LCP-A2MC), Université de Lorraine, 1 boulevard Arago, 57078, Metz Cedex 3, France

    Olivier Delhomme

Authors
  1. Vincent Lucaire
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  2. Jean-Jacques Schwartz
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  3. Olivier Delhomme
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  4. Ruben Ocampo-Torres
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  5. Maurice Millet
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Correspondence to Maurice Millet.

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Lucaire, V., Schwartz, JJ., Delhomme, O. et al. A sensitive method using SPME pre-concentration for the quantification of aromatic amines in indoor air. Anal Bioanal Chem 410, 1955–1963 (2018). https://doi.org/10.1007/s00216-018-0862-8

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  • DOI: https://doi.org/10.1007/s00216-018-0862-8

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