Analytical and Bioanalytical Chemistry

, Volume 409, Issue 10, pp 2501–2518

Field flow fractionation techniques to explore the “nano-world”


DOI: 10.1007/s00216-017-0180-6

Cite this article as:
Contado, C. Anal Bioanal Chem (2017) 409: 2501. doi:10.1007/s00216-017-0180-6


Field flow fractionation (FFF) techniques are used to successfully characterize several nanomaterials by sizing nano-entities and producing information about the aggregation/agglomeration state of nanoparticles. By coupling FFF techniques to specific detectors, researchers can determine particle-size distributions (PSDs), expressed as mass-based or number-based PSDs. This review considers FFF applications in the food, biomedical, and environmental sectors, mostly drawn from the past 4 y. It thus underlines the prominent role of asymmetrical flow FFF within the FFF family. By concisely comparing FFF techniques with other techniques suitable for sizing nano-objects, the advantages and the disadvantages of these instruments become clear. A consideration of select recent publications illustrates the state of the art of some lesser-known FFF techniques and innovative instrumental set-ups.


Field flow fractionation Nanoparticles Quantum dots Food additives Drug delivery systems Environmental nanoparticles 

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Chemical and Pharmaceutical SciencesUniversity of FerraraFerraraItaly

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