Analytical and Bioanalytical Chemistry

, Volume 408, Issue 24, pp 6613–6622 | Cite as

Rapid simultaneous analysis of 17 haloacetic acids and related halogenated water contaminants by high-performance ion chromatography-tandem mass spectrometry

  • Runmiao Xue
  • Ariel Donovan
  • Honglan ShiEmail author
  • John Yang
  • Bin Hua
  • Enos Inniss
  • Todd Eichholz
Research Paper


Haloacetic acids (HAAs), which include chloroacetic acids, bromoacetic acids, and emerging iodoacetic acids, are toxic water disinfection byproducts. General screening methodology is lacking for simultaneously monitoring chloro-, bromo-, and iodoacetic acids. In this study, a rapid and sensitive high-performance ion chromatography-tandem mass spectrometry method for simultaneous determination of chloro-, bromo-, and iodo- acetic acids and related halogenated contaminants including bromate, bromide, iodate, and iodide was developed to directly analyze water samples after filtration, eliminating the need for preconcentration, and chemical derivatization. The resulting method was validated in both untreated and treated water matrices including tap water, bottled water, swimming pool water, and both source water and drinking water from a drinking water treatment facility to demonstrate application potential. Satisfactory accuracies and precisions were obtained for all types of tested samples. The detection limits of this newly developed method were lower or comparable with similar techniques without the need for extensive sample treatment requirement and it includes all HAAs and other halogenated compounds. This provides a powerful methodology to water facilities for routine water quality monitoring and related water research, especially for the emerging iodoacetic acids.

Graphical abstract

High performance ion chromatography-tandem mass spectrometry method for detection of haloacetic acids in water


Haloacetic acids Iodoacetic acid Water disinfection byproducts High-performance ion chromatography-mass spectrometry Bromate 



This study was supported by US EPA STAR program (grant no. 83517301) and Missouri Department of Natural Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US EPA. The authors appreciate the support from the Chemistry Department, Center for Single Nanoparticle, Single Cell, and Single Molecule Monitoring (CS3M) and Environmental Research Center at Missouri University of Science and Technology. Special thanks to Casey Burton, Sisi Chen, Yongbo Dan, and Danielle West for their kind help on water sample collection and valuable suggestions during method development.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Runmiao Xue
    • 1
    • 2
  • Ariel Donovan
    • 1
    • 2
  • Honglan Shi
    • 1
    • 2
    Email author
  • John Yang
    • 3
  • Bin Hua
    • 3
  • Enos Inniss
    • 4
  • Todd Eichholz
    • 5
  1. 1.Department of Chemistry and Environmental Research CenterMissouri University of Science and TechnologyRollaUSA
  2. 2.Center for Single Nanoparticle, Single Cell, and Single Molecule Monitoring (CS3M)Missouri University of Science and TechnologyRollaUSA
  3. 3.Department of Agriculture and Environmental SciencesLincoln University of MissouriJefferson CityUSA
  4. 4.Department of Civil and Environmental EngineeringUniversity of Missouri-ColumbiaColumbiaUSA
  5. 5.Missouri Department of Natural ResourcesJefferson CityUSA

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