Skip to main content

Advertisement

Springer Nature Link
Log in

Collection and separation of extract in dispersive liquid-liquid microextraction with hollow fiber

  • Research Paper
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Dispersive liquid–liquid microextraction combined with collection of the extraction phase with the hollow fiber was applied to the extraction of estrogens from environmental water samples. 1-Undecanol with relatively lower toxicity was used as the extraction solvent. The hollow fiber was used to collect the extraction phase containing the analytes from the aqueous phase. Hollow fibers collecting the extraction phase were eluted with acetonitrile and the resulting eluate was analyzed by high performance liquid chromatography. Several parameters, including pH of sample, the type and volume of the extraction and dispersive solvent, salt concentration, extraction time, and collection time were optimized. Under the optimal experimental conditions, the limits of detection for estriol, 17α-estradiol, and ethynylestradiol were 4.58, 1.41, and 1.41 μg L–1, respectively. When the present method was applied to the analysis of real water samples, the recoveries of estrogens at two spiked levels were in the range of 55.8–107.4 %. In this method, the separation of the extraction phase and aqueous phase becomes easy with no need for centrifugation, refrigeration-thaw, or any special device. The hollow fiber was commercially available and the collection procedure was easy to perform, which make the present method have potential for automation and wide promotion. Small sizes of pores on the walls of the hollow fibers can block large molecules, which makes the present method have the potential for the treatment of complex matrices.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+
from $39.99 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Explore related subjects

Discover the latest articles, books and news in related subjects, suggested using machine learning.

References

  1. Sodré FF, Pescara IC, Montagner CC, Jardim WF. Assessing selected estrogens and xenoestrogens in Brazilian surface waters by liquid chromatography-tandem mass spectrometry. Microchem J. 2010;96:92–8.

    Article  Google Scholar 

  2. Matejicek D, Kuban V. Enhancing sensitivity of liquid chromatographic/ion-trap tandem mass spectrometric determination of estrogens by on-line pre-column derivatization. J Chromatogr A. 2008;1192:248–53.

    Article  CAS  Google Scholar 

  3. Loos R. Analytical methods for the new proposed priority substances of the European Water Framework Directive (WFD), JRC Technical Reports, European Union. 2012.

  4. Tomšíková H, Aufartová J, Solich P, Nováková L, Sosa-Ferrera Z, Santana-Rodríguez JJ. High-sensitivity analysis of female-steroid hormones in environmental samples. TrAC Trends Anal Chem. 2012;34:35–58.

    Article  Google Scholar 

  5. D'Orazio G, Asensio-Ramos M, Hernandez-Borges J, Fanali S, Rodriguez-Delgado MA. Estrogenic compounds determination in water samples by dispersive liquid-liquid microextraction and micellar electrokinetic chromatography coupled to mass spectrometry. J Chromatogr A. 2014;1344:109–21.

    Article  Google Scholar 

  6. Labadie P, Hill EM. Analysis of estrogens in river sediments by liquid chromatography-electrospray ionisation mass spectrometry. Comparison of tandem mass spectrometry and time-of-flight mass spectrometry. J Chromatogr A. 2007;1141:174–81.

    Article  CAS  Google Scholar 

  7. Chang CC, Huang SD. Determination of the steroid hormone levels in water samples by dispersive liquid-liquid microextraction with solidification of a floating organic drop followed by high-performance liquid chromatography. Anal Chim Acta. 2010;662:39–43.

    Article  CAS  Google Scholar 

  8. Zuo Y, Zhang K, Lin Y. Microwave-accelerated derivatization for the simultaneous gas chromatographic-mass spectrometric analysis of natural and synthetic estrogenic steroids. J Chromatogr A. 2007;1148:211–8.

    Article  CAS  Google Scholar 

  9. Fernandez MP, Ikonomou MG, Buchanan I. An assessment of estrogenic organic contaminants in Canadian waste waters. Sci Total Environ. 2007;373:250–69.

    Article  CAS  Google Scholar 

  10. Labadie P, Budzinski H. Determination of steroidal hormone profiles along the Jalle d'Eysines River (near Bordeaux, France). Environ Sci Technol. 2005;39:5113–20.

    Article  CAS  Google Scholar 

  11. Pailler JY, Krein A, Pfister L, Hoffmann L, Guignard C. Solid phase extraction coupled to liquid chromatography-tandem mass spectrometry analysis of sulfonamides, tetracyclines, analgesics, and hormones in surface water and wastewater in Luxembourg. Sci Total Environ. 2009;407:4736–43.

    Article  CAS  Google Scholar 

  12. Koh YK, Chiu TY, Boobis A, Cartmell E, Lester JN, Scrimshaw MD. Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2007;1173:81–7.

    Article  CAS  Google Scholar 

  13. Servos MR, Bennie DT, Burnison BK, Jurkovic A, McInnis R, Neheli T. Distribution of estrogens, 17β-estradiol and estrone, in Canadian municipal waste water treatment plants. Sci Total Environ. 2005;336:155–70.

    Article  CAS  Google Scholar 

  14. Lima DL, Silva CP, Schneider RJ, Otero M, Esteves VI. Application of dispersive liquid–liquid microextraction for estrogens' quantification by enzyme-linked immunosorbent assay. Talanta. 2014;125:102–6.

    Article  CAS  Google Scholar 

  15. Lima DL, Silva CP, Otero M, Esteves VI. Low cost methodology for estrogens monitoring in water samples using dispersive liquid-liquid microextraction and HPLC with fluorescence detection. Talanta. 2013;115:980–5.

    Article  CAS  Google Scholar 

  16. Trenholm RA, Vanderford BJ, Holady JC, Rexing DJ, Snyder SA. Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry. Chemosphere. 2006;65:1990–8.

    Article  CAS  Google Scholar 

  17. Pedrouzo M, Borrull F, Pocurull E, Marce RM. Estrogens and their conjugates: determination in water samples by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Talanta. 2009;78:1327–31.

    Article  CAS  Google Scholar 

  18. Nie Y, Qiang Z, Zhang H, Adams C. Determination of endocrine-disrupting chemicals in the liquid and solid phases of activated sludge by solid phase extraction and gas chromatography-mass spectrometry. J Chromatogr A. 2009;1216:7071–80.

    Article  CAS  Google Scholar 

  19. Grover DP, Zhang ZL, Readman JW, Zhou JL. A comparison of three analytical techniques for the measurement of steroidal estrogens in environmental water samples. Talanta. 2009;78:1204–10.

    Article  CAS  Google Scholar 

  20. Stafiej A, Pyrzynska K, Regan F. Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection. J Sep Sci. 2007;30:985–91.

    Article  CAS  Google Scholar 

  21. Huang Z, Lee HK. Performance of metal-organic framework MIL-101 after surfactant modification in the extraction of endocrine disrupting chemicals from environmental water samples. Talanta. 2015;143:366–73.

    Article  CAS  Google Scholar 

  22. Ben Fredj S, Nobbs J, Tizaoui C, Monser L. Removal of estrone (E1), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) from waste water by liquid–liquid extraction. Chem Eng J. 2015;262:417–26.

    Article  CAS  Google Scholar 

  23. Almeida C, Nogueira JM. Determination of steroid sex hormones in water and urine matrices by stir bar sorptive extraction and liquid chromatography with diode array detection. J Pharm Biomed Anal. 2006;41:1303–11.

    Article  CAS  Google Scholar 

  24. Wang L, Cai YQ, He B, Yuan CG, Shen DZ, Shao J. Determination of estrogens in water by HPLC-UV using cloud point extraction. Talanta. 2006;70:47–51.

    Article  CAS  Google Scholar 

  25. Rezaee M, Assadi Y, Milani Hosseini MR, Aghaee E, Ahmadi F, Berijani S. Determination of organic compounds in water using dispersive liquid-liquid microextraction. J Chromatogr A. 2006;1116:1–9.

    Article  CAS  Google Scholar 

  26. Zhang R, Wang C, Yue Q, Zhou T, Li N, Zhang H. Ionic liquid foam floatation coupled with ionic liquid dispersive liquid-liquid microextraction for the separation and determination of estrogens in water samples by high-performance liquid chromatography with fluorescence detection. J Sep Sci. 2014;37:3133–41.

    Article  CAS  Google Scholar 

  27. Socas-Rodriguez B, Hernandez-Borges J, Asensio-Ramos M, Herrera-Herrera AV, Palenzuela JA, Rodriguez-Delgado MA. Determination of estrogens in environmental water samples using 1,3-dipentylimidazolium hexafluorophosphate ionic liquid as extraction solvent in dispersive liquid-liquid microextraction. Electrophoresis. 2014;35:2479–87.

    Article  CAS  Google Scholar 

  28. Wu C, Liu H, Liu W, Wu Q, Wang C, Wang Z. Determination of organophosphorus pesticides in environmental water samples by dispersive liquid–liquid microextraction with solidification of floating organic droplet followed by high-performance liquid chromatography. Anal Bioanal Chem. 2010;397:2543–9.

    Article  CAS  Google Scholar 

  29. Ranjbari E, Biparva P, Hadjmohammadi MR. Utilization of inverted dispersive liquid–liquid microextraction followed by HPLC-UV as a sensitive and efficient method for the extraction and determination of quercetin in honey and biological samples. Talanta. 2012;89:117–23.

    Article  CAS  Google Scholar 

  30. Najafi NM, Tavakoli H, Abdollahzadeh Y, Alizadeh R. Comparison of ultrasound-assisted emulsification and dispersive liquid–liquid microextraction methods for the speciation of inorganic selenium in environmental water samples using low density extraction solvents. Anal Chim Acta. 2012;714:82–8.

    Article  CAS  Google Scholar 

  31. Shi ZG, Lee HK. Dispersive liquid–liquid microextraction coupled with dispersive micro-solid-phase extraction for the fast determination of polycyclic aromatic hydrocarbons in environmental water samples. Anal Chem. 2010;82:1540–5.

    Article  CAS  Google Scholar 

  32. Pezo D, Salafranca J, Nerín C. Development of an automatic multiple dynamic hollow fibre liquid-phase microextraction procedure for specific migration analysis of new active food packagings containing essential oils. J Chromatogr A. 2007;1174:85–94.

    Article  CAS  Google Scholar 

  33. Salafranca J, Pezo D, Nerin C. Assessment of specific migration to aqueous simulants of a new active food packaging containing essential oils by means of an automatic multiple dynamic hollow fibre liquid phase microextraction system. J Chromatogr A. 2009;1216:3731–9.

    Article  CAS  Google Scholar 

  34. Tao Y, Liu JF, Wang T, Jiang GB. Simultaneous conduction of two- and three-phase hollow-fiber-based liquid-phase microextraction for the determination of aromatic amines in environmental water samples. J Chromatogr A. 2009;1216:756–62.

    Article  CAS  Google Scholar 

  35. Peng JF, Liu JF, Hu XL, Jiang GB. Direct determination of chlorophenols in environmental water samples by hollow fiber supported ionic liquid membrane extraction coupled with high-performance liquid chromatography. J Chromatogr A. 2007;1139:165–70.

    Article  CAS  Google Scholar 

  36. Lei L, Kang MQ, Li N, Yang X, Liu ZL, Wang ZB. Determination of sex hormones in cosmetic products by magnetically stirring extraction bar liquid–liquid microextraction coupled with high performance liquid chromatography. Anal Methods. 2014;6:3674.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors acknowledge support for this work by the National Natural Science Foundation of China (21207047 and 31300621).

Author information

Authors and Affiliations

  1. College of Chemistry, Jilin University, Qianjin Street 2699, Changchun, Jilin, 130012, China

    Kun Wang, Na Li, Lei Lei, Xiao Yang, Dan Li, Shuang Zang, Hanqi Zhang, Aimin Yu & Ziwei Zhang

  2. College of Chemistry and Life Science, Changchun University of Technology, Yanan Street 2055, Changchun, Jilin, 130012, China

    Zhibing Wang

Authors
  1. Kun Wang
    View author publications

    Search author on:PubMed Google Scholar

  2. Na Li
    View author publications

    Search author on:PubMed Google Scholar

  3. Lei Lei
    View author publications

    Search author on:PubMed Google Scholar

  4. Xiao Yang
    View author publications

    Search author on:PubMed Google Scholar

  5. Zhibing Wang
    View author publications

    Search author on:PubMed Google Scholar

  6. Dan Li
    View author publications

    Search author on:PubMed Google Scholar

  7. Shuang Zang
    View author publications

    Search author on:PubMed Google Scholar

  8. Hanqi Zhang
    View author publications

    Search author on:PubMed Google Scholar

  9. Aimin Yu
    View author publications

    Search author on:PubMed Google Scholar

  10. Ziwei Zhang
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Ziwei Zhang.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(PDF 519 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, K., Li, N., Lei, L. et al. Collection and separation of extract in dispersive liquid-liquid microextraction with hollow fiber. Anal Bioanal Chem 408, 3359–3367 (2016). https://doi.org/10.1007/s00216-016-9410-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-016-9410-6

Keywords