Analytical and Bioanalytical Chemistry

, Volume 408, Issue 5, pp 1391–1397 | Cite as

A smart pipette for equipment-free separation and delivery of plasma for on-site whole blood analysis

  • Sung B. Im
  • Sang C. Kim
  • Joon S. ShimEmail author
Rapid Communication


A novel device of smart pipette has been suggested to extract and deliver plasma from whole blood in a disposable format. By operating an on-chip disposable micropump, approximately 30 μL of plasma was obtained from 100 μL of whole blood within 5 min without any external equipment for point-of-care blood analysis.

Graphical Abstract

A novel device of smart pipette as a stand-alone lab on a chip (LOC) device has been successfully developed to rapidly extract and deliver 30 μL of plasma within 5 min from 100 μL of whole blood with 45 % hematocrit.


Blood separation Micropump Lab on a chip Point-of-care testing Microfilter 



The authors gratefully acknowledge the support of this work by the Kwangwoon Research Grant of 2014. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. NRF-2015R1D1A1A01060369) and Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2015 (Grants No. C0299553).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

216_2015_9259_MOESM1_ESM.pdf (709 kb)
ESM 1 (PDF 606 kb)
216_2015_9259_MOESM2_ESM.mp4 (18.9 mb)
ESM 2 (MP4 19360 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Bio IT Convergence Laboratory, Department of Electronics Convergence EngineeringKwangwoon UniversitySeoulRepublic of Korea

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