Analytical and Bioanalytical Chemistry

, Volume 407, Issue 27, pp 8225–8231

Plasmonic vertical dimer arrays as elements for biosensing

  • Andreas Horrer
  • Katrin Krieg
  • Kathrin Freudenberger
  • Sabrina Rau
  • Lothar Leidner
  • Günter Gauglitz
  • Dieter P. Kern
  • Monika Fleischer
Research Paper

DOI: 10.1007/s00216-015-8974-x

Cite this article as:
Horrer, A., Krieg, K., Freudenberger, K. et al. Anal Bioanal Chem (2015) 407: 8225. doi:10.1007/s00216-015-8974-x
Part of the following topical collections:
  1. Nanospectroscopy

Abstract

Localized surface plasmon resonances of metallic nanoparticles can be used for biosensing because of their sensitive dependence on the refractive index of the surrounding medium. The binding of molecules to the particles causes a change of the effective refractive index in their close vicinity, which leads to a reversible shift of the resonance. We present simulations and sensing experiments of a plasmon resonance based biosensor that makes use of the narrow antisymmetric resonance in coupled plasmonic vertical dimers. The sensitivity of the antisymmetric resonance is compared with that of a surface lattice resonance for refractive index sensing of bulk and of thin layers of molecules. The functionality of such a sensor surface is demonstrated via a testosterone immunoassay for detection of antibody from a solution by binding to surface-immobilized antigen in a fluidic channel.

Keywords

Plasmonic nanostructures Biosensing Label-free immunoassay Vertical dimer Testosterone 

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Andreas Horrer
    • 1
  • Katrin Krieg
    • 2
  • Kathrin Freudenberger
    • 2
  • Sabrina Rau
    • 2
  • Lothar Leidner
    • 2
  • Günter Gauglitz
    • 2
  • Dieter P. Kern
    • 1
  • Monika Fleischer
    • 1
  1. 1.Institute for Applied Physics and Center LISA+University of TübingenTübingenGermany
  2. 2.Institute of Physical and Theoretical ChemistryUniversity of TübingenTübingenGermany

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