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Analytical and Bioanalytical Chemistry

, Volume 407, Issue 25, pp 7667–7672 | Cite as

Glucaminium ionic liquid-functionalized stationary phase for the separation of nucleosides in hydrophilic interaction chromatography

  • Qiong Jiang
  • Mingliang Zhang
  • Xusheng Wang
  • Yong Guo
  • Hongdeng QiuEmail author
  • Shusheng ZhangEmail author
Research Paper

Abstract

A glucaminium-based ionic liquid stationary phase was prepared via facile epoxy-amine reaction and subsequent quaternization. Successful immobilization of glucaminium-based ionic liquid onto silica surface was validated by elemental analysis and infrared spectroscopy. The new stationary phase was evaluated for the separation of nucleosides in hydrophilic interaction liquid chromatography (HILIC). Effects of various factors, such as acetonitrile concentration, salt concentration, pH value, as well as column temperature, on the chromatographic behavior toward nucleosides were studied in detail. The results indicated that this new stationary phase can be used for separation of water-soluble polar substances in HILIC mode. The retention of solutes on the stationary phase was influenced by a mixed-mode retention mechanism with a combination of adsorptive and partitioning interactions.

Keywords

Ionic liquid Glucaminium∙stationary phase Hydrophilic interaction High-performance liquid chromatography 

Notes

Acknowledgments

The authors express their thanks to the support of the “Hundred Talents Program” of Chinese Academy of Sciences, and the National Natural Science Foundation of China (No. 21475142).

Supplementary material

216_2015_8927_MOESM1_ESM.pdf (198 kb)
ESM 1 (PDF 197 kb)

References

  1. 1.
    Welton T (1999) Chem Rev 99:2071–2083CrossRefGoogle Scholar
  2. 2.
    Welton T (2008) Ionic liquids in synthesis, Wiley Online LibraryGoogle Scholar
  3. 3.
    Olivier-Bourbigou H, Magna L (2002) J Mol Catal A Chem 182:419–437CrossRefGoogle Scholar
  4. 4.
    Tunckol M, Durand J, Serp P (2012) Carbon 50(12):4303–4334CrossRefGoogle Scholar
  5. 5.
    Liu J, Jiang G, Liu J, Jönsson JÅ (2005) TrAC Trends Anal Chem 24:20–27CrossRefGoogle Scholar
  6. 6.
    Sun P, Armstrong DW (2010) Anal Chim Acta 661:1–16CrossRefGoogle Scholar
  7. 7.
    López-Darias J, Germán-Hernández M, Pino V, Afonso AM (2010) Talanta 80:1611–1618CrossRefGoogle Scholar
  8. 8.
    Ho TD, Zhang C, Hantao LW, Anderson JL (2014) Anal Chem 86:262–285CrossRefGoogle Scholar
  9. 9.
    Zhou Q, Bai H, Xie G, Xiao J (2008) J Chromatogr A 1177:43–49CrossRefGoogle Scholar
  10. 10.
    Vidal L, Riekkola M-L, Canals A (2012) Anal Chim Acta 715:19–41CrossRefGoogle Scholar
  11. 11.
    Yu H, Ho TD, Anderson JL (2013) Trends Anal Chem 45:219–232CrossRefGoogle Scholar
  12. 12.
    Ding J, Welton T, Armstrong DW (2004) Anal Chem 76:6819–6822CrossRefGoogle Scholar
  13. 13.
    Anderson JL, Armstrong DW (2003) Anal Chem 75:4851–4858CrossRefGoogle Scholar
  14. 14.
    Xiao XH, Zhao L, Liu X, Jiang SX (2004) Anal Chim Acta 519:207–211CrossRefGoogle Scholar
  15. 15.
    Wang Q, Baker GA, Baker SN, Colon LA (2006) Analyst 131:1000–1005CrossRefGoogle Scholar
  16. 16.
    Berthod A, Ruiz-Ángel MJ, Carda-Broch S (2008) J Chromatogr A 1184:6–18CrossRefGoogle Scholar
  17. 17.
    Bi W, Zhou J, Row K-H (2012) Separ Sci Technol 47:360–369CrossRefGoogle Scholar
  18. 18.
    Pino V, Afonso AM (2012) Anal Chim Acta 714:20–37CrossRefGoogle Scholar
  19. 19.
    Zhang M, Liang X, Jiang S, Qiu H (2014) TrAC Trends Anal Chem 53:60–72CrossRefGoogle Scholar
  20. 20.
    Joshi MD, Chalumot G, Kim Y-W, Anderson JL (2012) Chem Commun 48:1410–1412CrossRefGoogle Scholar
  21. 21.
    Joshi MD, Li T, Zhong Q, Anderson JL (2013) J Chromatogr A 1308:161–165CrossRefGoogle Scholar
  22. 22.
    Qiu H, Liang X, Sun M, Jiang S (2011) Anal Bioanal Chem 399:3307–3322CrossRefGoogle Scholar
  23. 23.
    Joshi MD, Steyer DJ, Anderson JL (2012) Anal Chim Acta 740:66–73CrossRefGoogle Scholar
  24. 24.
    Ho TD, Joshi MD, Silver MA, Anderson JL (2012) J Chromatogr A 1240:29–44CrossRefGoogle Scholar
  25. 25.
    Qiao L, Wang S, Li H, Shan YH, Dou AB, Shi XZ, Xu GW (2014) J Chromatogr A 1360:240–247CrossRefGoogle Scholar
  26. 26.
    Warwel S, Klaas MR, Schier H, Brüse F, Wiege B (2001) Eur J Lipid Sci Technol 103:645–654CrossRefGoogle Scholar
  27. 27.
    Qiu H, Mallik AK, Takafuji M, Jiang S, Ihara H (2012) RSC Adv 137:2553–2555Google Scholar
  28. 28.
    Zhang ML, Chen J, Gua TN, Qiu HD, Jiang SX (2014) Talanta 126:177–184CrossRefGoogle Scholar
  29. 29.
    Qiu H, Mallik AK, Takafuji M, Liu X, Jiang S, Ihara H (2012) J Chromatogr A 1232:116–122CrossRefGoogle Scholar
  30. 30.
    Jia J, Liu S, Qiu H, Guo Y, Liu X, Jiang S (2013) Anal Bioanal Chem 406:2163–2170CrossRefGoogle Scholar
  31. 31.
    Murray F (1995) Regul Toxicol Pharmacol 22:221–230CrossRefGoogle Scholar
  32. 32.
    Stahlberg J (1999) J Chromatogr A 855:3–55CrossRefGoogle Scholar
  33. 33.
    Alpert AJ (2008) Anal Chem 80:62–76CrossRefGoogle Scholar
  34. 34.
    McCalley DV (2010) J Chromatogr A 1217:3408–3417CrossRefGoogle Scholar
  35. 35.
    Qiao L, Dou A, Shi X, Li H, Shan Y, Lu X, Xu G (2013) J Chromatogr A 1286:137–145CrossRefGoogle Scholar
  36. 36.
    Chirita RI, West C, Zubrzycki S, Finaru AL, Elfakir C (2011) J Chromatogr A 1218:5939–5963CrossRefGoogle Scholar
  37. 37.
    Rodriguez-Gonzalo E, Garcia-Gomez D, Carabias-Martinez R (2011) J Chromatogr A 1218:9055–9063CrossRefGoogle Scholar
  38. 38.
    Molnár-Perl I (2000) J Chromatogr A 891:1–32CrossRefGoogle Scholar
  39. 39.
    Guo Y, Gaiki S (2005) J Chromatogr A 1074:71–80CrossRefGoogle Scholar
  40. 40.
    Sun M, Feng J, Luo C, Liu X, Jiang S (2014) Anal Bioanal Chem 406:2651–2658CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Chemistry Department, Key Laboratory of Chemical Biology and Organic Chemistry of HenanZhengzhou UniversityZhengzhouChina
  2. 2.Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouChina

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