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Silica-based 2-(N,N-dimethylamino)-1,3-propanediol hydrophilic interaction liquid chromatography stationary phase for separating cephalosporins and carbapenems

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Abstract

A silica-based stationary phase bearing both hydrophilic hydroxyl and amino groups was developed by covalently bonding a small molecular N,N-dimethylamino 1,3-propanediol moiety onto silica beads via copper(I)-catalyzed Huisgen azide–alkyne 1,3-dipolar cycloaddition (CuAAC). This new stationary phase showed good HILIC characteristics and high column efficiency (the theoretical plate number is up to 37000 plates m−1 in the case of inosine) in the separation of polar compounds, such as nucleosides and bases, organic acids, cephalosporins, and carbapenems.

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Acknowledgments

This research was sponsored by National Natural Science Foundation of China (No. 21372081, No. 21172072)

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Authors and Affiliations

  1. School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

    Wei Yin, Lingping Cheng, Huihui Chai, Ruiqiang Guo, Renhua Liu & Changhu Chu

  2. Department of Chemistry and Physics, University of St. Thomas, Houston, TX, 77006, USA

    John A. Palasota & Xiaohui Cai

Authors
  1. Wei Yin
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  2. Lingping Cheng
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  3. Huihui Chai
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  4. Ruiqiang Guo
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  5. Renhua Liu
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  6. Changhu Chu
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  7. John A. Palasota
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  8. Xiaohui Cai
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Corresponding author

Correspondence to Changhu Chu.

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Yin, W., Cheng, L., Chai, H. et al. Silica-based 2-(N,N-dimethylamino)-1,3-propanediol hydrophilic interaction liquid chromatography stationary phase for separating cephalosporins and carbapenems. Anal Bioanal Chem 407, 6217–6220 (2015). https://doi.org/10.1007/s00216-015-8779-y

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  • DOI: https://doi.org/10.1007/s00216-015-8779-y

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