Bipolar disorder: recent advances and future trends in bioanalytical developments for biomarker discovery


In this manuscript we briefly describe bipolar disorder (a depressive and manic mental disease), its classification, its effects on the patient, which sometimes include suicidal tendencies, and the drugs used for treatment. We also address the status quo with regard to diagnosis of bipolar disorder and recent advances in bioanalytical approaches for biomarker discovery. These approaches focus on blood samples (serum and plasma) and proteins as the main biomarker targets, and use various strategies for protein depletion. Strategies include use of commercially available kits or other homemade strategies and use of classical proteomics methods for protein identification based on “bottom-up” or “top-down” approaches, which used SELDI, ESI, or MALDI as sources for mass spectrometry, and up-to-date mass analyzers, for example Orbitrap. We also discuss some future objectives for treatment of this disorder and possible directions for the correct diagnosis of this still-unclear mental illness.

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The authors thank Fundação de Amparo as Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brasília, Brazil), and the Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior (CAPES, Brasília, Brazil) for financial support and fellowships.

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Correspondence to Marco Aurélio Zezzi Arruda.

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Published in the topical collection celebrating ABCs 13th Anniversary.

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de Jesus, J.R., de Campos, B.K., Galazzi, R.M. et al. Bipolar disorder: recent advances and future trends in bioanalytical developments for biomarker discovery. Anal Bioanal Chem 407, 661–667 (2015).

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  • Bipolar disorder
  • Mood disorders
  • Experimental approaches
  • Blood biomarkers