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Plasma-based ambient desorption/ionization mass spectrometry: state-of-the-art in qualitative and quantitative analysis

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Abstract

Ambient desorption/ionization mass spectrometry (ADI-MS) aims to enable direct analysis of gaseous, liquid, and/or solid samples under ambient conditions. In ADI-MS, different types of desorption/ionization sources are classified according to their basic method of operation, namely spray-based, laser-based, or plasma-based. This review discusses many of the plasma-based techniques coupled to mass spectrometry in terms of their current performance in fast qualitative screening and quantitative analysis. Critical aspects, for example sample preparation and introduction, quantification, and matrix effects, are addressed. Furthermore, the applicability of plasma-based sources to portable mass spectrometers and their capabilities in imaging experiments are summarized. The applications discussed are of two types. In one, direct screening is performed without any or with minimal sample pretreatment. Samples with low matrix content are qualitatively analyzed without interferences. The other, more challenging applications, namely samples with high matrix content and most quantitative analysis, typically require sample preparation ranging from simple dilution to extensive multi-step procedures.

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Acknowledgments

The authors thank the German Research Foundation (DFG) for financial support (grant EN-927/1-1) and the Alexander von Humboldt foundation for sponsoring the research stay of Dr. Shelley.

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Authors and Affiliations

  1. Institute of Inorganic and Analytical Chemistry, University of Muenster, Corrensstraße 30, 48149, Münster, Germany

    Anastasia Albert & Jacob T. Shelley

  2. Department of Chemistry, Kent State University, Kent, OH, 44242, USA

    Jacob T. Shelley

  3. Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Straße 2, 57076, Siegen, Germany

    Carsten Engelhard

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  1. Anastasia Albert
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  2. Jacob T. Shelley
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  3. Carsten Engelhard
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Correspondence to Carsten Engelhard.

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Albert, A., Shelley, J.T. & Engelhard, C. Plasma-based ambient desorption/ionization mass spectrometry: state-of-the-art in qualitative and quantitative analysis. Anal Bioanal Chem 406, 6111–6127 (2014). https://doi.org/10.1007/s00216-014-7989-z

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  • DOI: https://doi.org/10.1007/s00216-014-7989-z

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