Analytical and Bioanalytical Chemistry

, Volume 406, Issue 29, pp 7419–7430 | Cite as

Zoom-TOFMS: addition of a constant-momentum-acceleration “zoom” mode to time-of-flight mass spectrometry

  • Elise A. Dennis
  • Alexander W. Gundlach-Graham
  • Steven J. Ray
  • Christie G. Enke
  • Charles J. Barinaga
  • David W. Koppenaal
  • Gary M. Hieftje
Research Paper
Part of the following topical collections:
  1. Emerging Concepts and Strategies in Analytical Glow Discharges

Abstract

In this study, we demonstrate the performance of a new mass spectrometry concept called zoom time-of-flight mass spectrometry (zoom-TOFMS). In our zoom-TOFMS instrument, we combine two complementary types of TOFMS: conventional, constant-energy acceleration (CEA) TOFMS and constant-momentum acceleration (CMA) TOFMS to provide complete mass-spectral coverage as well as enhanced resolution and duty factor for a narrow, targeted mass region, respectively. Alternation between CEA- and CMA-TOFMS requires only that electrostatic instrument settings (i.e., reflectron and ion optics) and ion acceleration conditions be changed. The prototype zoom-TOFMS instrument has orthogonal-acceleration geometry, a total field-free distance of 43 cm, and a direct-current glow-discharge ionization source. Experimental results demonstrate that the CMA-TOFMS “zoom” mode offers resolution enhancement of 1.6 times over single-stage acceleration CEA-TOFMS. For the atomic mass range studied here, the maximum resolving power at full-width half-maximum observed for CEA-TOFMS was 1,610 and for CMA-TOFMS the maximum was 2,550. No difference in signal-to-noise (S/N) ratio was observed between the operating modes of zoom-TOFMS when both were operated at equivalent repetition rates. For a 10-kHz repetition rate, S/N values for CEA-TOFMS varied from 45 to 990 and from 67 to 10,000 for CMA-TOFMS. This resolution improvement is the result of a linear TOF-to-mass scale and the energy-focusing capability of CMA-TOFMS. Use of CMA also allows ions outside a given m/z range to be rejected by simple ion-energy barriers to provide a substantial improvement in duty factor.

Keywords

Mass spectrometry ICP-MS Spectroscopy Instrumentation Metals Heavy metals 

Supplementary material

216_2014_7875_MOESM1_ESM.pdf (4.2 mb)
ESM 1(PDF 4.23 MB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Elise A. Dennis
    • 1
  • Alexander W. Gundlach-Graham
    • 1
  • Steven J. Ray
    • 1
  • Christie G. Enke
    • 1
    • 2
  • Charles J. Barinaga
    • 3
  • David W. Koppenaal
    • 3
  • Gary M. Hieftje
    • 1
  1. 1.Department of ChemistryIndiana UniversityBloomingtonUSA
  2. 2.Department of Chemistry and Chemical BiologyUniversity of New MexicoAlbuquerqueUSA
  3. 3.Pacific Northwest National LaboratoryRichlandUSA

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