Analytical and Bioanalytical Chemistry

, Volume 406, Issue 14, pp 3263–3277 | Cite as

Cellphone-based devices for bioanalytical sciences

  • Sandeep Kumar Vashist
  • Onur Mudanyali
  • E. Marion Schneider
  • Roland Zengerle
  • Aydogan OzcanEmail author
Part of the following topical collections:
  1. Multiplex Platforms in Diagnostics and Bioanalytics


During the last decade, there has been a rapidly growing trend toward the use of cellphone-based devices (CBDs) in bioanalytical sciences. For example, they have been used for digital microscopy, cytometry, read-out of immunoassays and lateral flow tests, electrochemical and surface plasmon resonance based bio-sensing, colorimetric detection and healthcare monitoring, among others. Cellphone can be considered as one of the most prospective devices for the development of next-generation point-of-care (POC) diagnostics platforms, enabling mobile healthcare delivery and personalized medicine. With more than 6.5 billion cellphone subscribers worldwide and approximately 1.6 billion new devices being sold each year, cellphone technology is also creating new business and research opportunities. Many cellphone-based devices, such as those targeted for diabetic management, weight management, monitoring of blood pressure and pulse rate, have already become commercially-available in recent years. In addition to such monitoring platforms, several other CBDs are also being introduced, targeting e.g., microscopic imaging and sensing applications for medical diagnostics using novel computational algorithms and components already embedded on cellphones. This report aims to review these recent developments in CBDs for bioanalytical sciences along with some of the challenges involved and the future opportunities.


The universal Rapid Diagnostic Test (RDT) reader developed at UCLA. It can read various lateral flow assays for point-of-care and telemedicine applications


Cellphone Bioanalytical sciences Diagnostics Point-of-care Digital health 



Blood pressure


Cellphone-based device


Conformité Européenne




Enzyme-linked immunosorbent assay


European Society of Hypertension


Food and Drug Administration






High-sensitivity C-reactive protein


Interstitial fluid


Light-emitting diode


Lateral flow assay


Lateral flow immunoassay


Mobile Healthcare


Mobile image ratiometry


Microtiter plate


Near-field communication


Prostate cancer antigen diagnostic marker 1




Plasmodium falciparum histidine-rich protein 2




Quantum dot


Red blood cells


Rapid diagnostic test


Radio frequency identification device


Radar responsive


Signal-to-noise ratio


Surface plasmon resonance


Thyroid stimulating hormone (TSH)


β2 microglobulin



Ozcan Research Group gratefully acknowledges the support of the Presidential Early Career Award for Scientists and Engineers (PECASE), Army Research Office (ARO) Life Sciences Division, ARO Young Investigator Award, National Science Foundation (NSF) CAREER Award, NSF CBET Biophotonics Program, NSF EFRI Award, Office of Naval Research (ONR) Young Investigator Award and National Institutes of Health (NIH) Director’s New Innovator Award DP2OD006427 from the Office of the Director, National Institutes of Health. Finally, the authors acknowledge various clinicians working in the field of intensive care for their intellectual support toward this review of future applications of smartphone based diagnostics tools to facilitate better patient monitoring.

Conflict of interest

A.O. is the co-founder of a start-up company (Holomic LLC) which aims to commercialize computational imaging and sensing technologies licensed from UCLA. O.M is currently employed by the same start-up company.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Sandeep Kumar Vashist
    • 1
  • Onur Mudanyali
    • 2
    • 3
    • 4
  • E. Marion Schneider
    • 5
  • Roland Zengerle
    • 1
    • 6
    • 7
  • Aydogan Ozcan
    • 2
    • 3
    • 4
    Email author
  1. 1.HSG-IMIT - Institut für Mikro- und InformationstechnikFreiburgGermany
  2. 2.Electrical Engineering DepartmentUniversity of CaliforniaLos AngelesUSA
  3. 3.Bioengineering DepartmentUniversity of CaliforniaLos AngelesUSA
  4. 4.California NanoSystems Institute (CNSI)University of CaliforniaLos AngelesUSA
  5. 5.Sektion Experimentelle AnaesthesiologieUniversity Hospital UlmUlmGermany
  6. 6.Laboratory for MEMS Applications, Department of Microsystems Engineering - IMTEKUniversity of FreiburgFreiburgGermany
  7. 7.BIOSS - Centre for Biological Signalling StudiesUniversity of FreiburgFreiburgGermany

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