Analytical and Bioanalytical Chemistry

, Volume 406, Issue 4, pp 1259–1266 | Cite as

Multi-residue analysis of emerging pollutants in sediment using QuEChERS-based extraction followed by LC-MS/MS analysis

  • Alexandra Berlioz-Barbier
  • Antoine Vauchez
  • Laure Wiest
  • Robert Baudot
  • Emmanuelle Vulliet
  • Cécile Cren-Olivé


Emerging contaminants are suspected to cause adverse effects in humans and wildlife. Aquatic ecosystems are continuously contaminated by agricultural and industrial sources. To establish a causality relationship between the occurrence of contaminants in the environment and disease, experiments including all environmental matrices must be performed. Consequently, the current analytical tools must be improved. A new multi-residue method for analysing 15 emerging pollutants in sediments based on the Quick, Easy, Cheap, Effective, Rugged and Safe approach is reported. The development of such a multirisque, inter-family method for sediment including pharmaceuticals, pesticides, personal care products and plasticizers is reported for the first time. The procedure involves salting-out liquid–liquid extraction using acetonitrile and clean-up with dispersive solid phase extraction, followed by liquid chromatography coupled with tandem mass spectrometry. The validated analytical procedure exhibited recoveries between 40 and 98 % for every target compound. This methodology facilitated the determination of pollutant contents at nanogram-per-gram concentrations.


LC-MS/MS QuEChERS Multi-residue Emerging pollutants Sediment 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Alexandra Berlioz-Barbier
    • 1
  • Antoine Vauchez
    • 1
  • Laure Wiest
    • 1
  • Robert Baudot
    • 1
  • Emmanuelle Vulliet
    • 1
  • Cécile Cren-Olivé
    • 1
  1. 1.Université de Lyon-Institut des Sciences AnalytiquesUMR 5280 CNRS-Equipe TRACESVilleurbanneFrance

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