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Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health

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Abstract

The “A-type” proanthocyanidins in cranberry fruit (Vaccinium macrocarpon Ait.) are bioactive components associated with prevention of urinary tract infections (UTI). Cranberry juice, fruit (fresh and dried), functional foods, and cranberry dietary supplements are promoted for prevention of UTI and for maintenance of urinary tract health (UTH), on the basis of their content of cranberry proanthocyanidins (c-PAC) with “A-type” interflavan bonds. With increasing consumer use of cranberries for maintenance of UTH and an expanding number of commercial cranberry products of different types, the availability of unified methods for measuring levels of c-PAC is important. This review discusses quantitative and qualitative analysis of c-PAC with “A-type” interflavan bonds in relation to their biological activity for UTI prevention. The integrity (including authenticity, standardization, efficacy, and safety) of cranberry fruit, juices, and dietary supplements may now be measured by using recent advances in mass spectrometry, liquid chromatography, production of c-PAC standards, and improved simple quantitative techniques.

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Authors and Affiliations

  1. Complete Phytochemical Solutions, LLC, 317 South Street, Cambridge, WI, 52523, USA

    Christian G. Krueger, Jess D. Reed & Amy B. Howell

  2. Reed Research Group, Dept. Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Drive, Madison, WI, 53706, USA

    Christian G. Krueger & Jess D. Reed

  3. Dept. of Food Science, University of Wisconsin-Madison, 1605 Linden Drive, Madison, WI, 53706, USA

    Rodrigo P. Feliciano

  4. Marucci Center for Blueberry Cranberry Research, Rutgers University, 125A Lake Oswego Rd, Chatsworth, NJ, 08019, USA

    Amy B. Howell

Authors
  1. Christian G. Krueger
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  2. Jess D. Reed
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  3. Rodrigo P. Feliciano
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  4. Amy B. Howell
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Correspondence to Christian G. Krueger.

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Published in the topical collection Functional Foods and Dietary Supplements with guest editors Melissa M. Phillips and Catherine A. Rimmer.

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Krueger, C.G., Reed, J.D., Feliciano, R.P. et al. Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Anal Bioanal Chem 405, 4385–4395 (2013). https://doi.org/10.1007/s00216-013-6750-3

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  • DOI: https://doi.org/10.1007/s00216-013-6750-3

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