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Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends

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Abstract

Anticancer metallodrug development has for a long time been characterised by the similarity of new drug candidates to cisplatin and DNA as the primary target. Recent advances in bioanalytical techniques with high sensitivity and selectivity have revealed that metal-based drugs can undergo a wide range of biomolecular interactions beyond DNA and have generated interest in proteins as possible targets for metallodrugs. In fact, implementation of metallomics approaches that are able to reveal the fate of the compounds in biological systems can help to move drug development towards more targeted and rational design of novel metallodrugs. Additionally, proteomic screening and gene expression analysis can provide insight into physiological response to drug treatment and identify the reasons for drug resistance. Herein, we review selected applications which led to a better understanding of the mode of action of clinically established metal-based anticancer agents and novel metallodrug candidates.

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References

  1. Shaw CF (1999) Chem Rev 99:2589–2600

    Article  CAS  Google Scholar 

  2. Kelland L (2007) Nat Rev Cancer 7:573–584

    Article  CAS  Google Scholar 

  3. Ott I, Gust R (2007) Arch Pharm 340:117–126

    Article  CAS  Google Scholar 

  4. Jakupec MA, Galanski M, Arion VB, Hartinger CG, Keppler BK (2008) Dalton Trans:183–194

  5. Zhang X-W, Yan X-J, Zhou Z-R, Yang F-F, Wu Z-Y, Sun H-B, Liang W-X, Song A-X, Lallemand-Breitenbach V, Jeanne M, Zhang Q-Y, Yang H-Y, Huang Q-H, Zhou G-B, Tong J-H, Zhang Y, Wu J-H, Hu H-Y, de Thé H, Chen S-J, Chen Z (2010) Science 328:240–243

    Article  CAS  Google Scholar 

  6. Dyson PJ, Sava G (2006) Dalton Trans:1929–1933

  7. Sava G, Bergamo A, Dyson PJ (2011) Dalton Trans 40:9069–9075

    Article  CAS  Google Scholar 

  8. Sava G, Jaouen G, Hillard EA, Bergamo A (2012) Dalton Trans 41:8226–8234

    Article  CAS  Google Scholar 

  9. Graf N, Lippard SJ (2012) Adv Drug Deliv Rev 64:993–1004

    Article  CAS  Google Scholar 

  10. Galanski M, Keppler BK (2012) Tumor-targeting strategies with anticancer platinum complexes. In: Kratz F, Senter P, Steinhagen H (eds) Drug delivery in oncology: From basic research to cancer therapy, vol 3, Wiley–VCH Verlag GmbH & Co. KGaA, Weinheim, pp 1605–1629

    Google Scholar 

  11. Gasser G, Ott I, Metzler-Nolte N (2011) J Med Chem 54:3–25

    Article  CAS  Google Scholar 

  12. Hartinger CG, Dyson PJ (2009) Chem Soc Rev 38:391–401

    Article  CAS  Google Scholar 

  13. Sava G, Zorzet S, Turrin C, Vita F, Soranzo M, Zabucchi G, Cocchietto M, Bergamo A, DiGiovine S, Pezzoni G, Sartor L, Garbisa S (2003) Clin Cancer Res 9:1898–1905

    CAS  Google Scholar 

  14. Ang WH, Khalaila I, Allardyce CS, Juillerat-Jeanneret L, Dyson PJ (2005) J Am Chem Soc 127:1382–1383

    Article  CAS  Google Scholar 

  15. Parker LJ, Italiano LC, Morton CJ, Hancock NC, Ascher DB, Aitken JB, Harris HH, Campomanes P, Rothlisberger U, De Luca A, Lo Bello M, Ang W-H, Dyson PJ, Parker MW (2011) Chem Eur J 17:7806–7816

    Article  CAS  Google Scholar 

  16. Blanck S, Maksimoska J, Baumeister J, Harms K, Marmorstein R, Meggers E (2012) Angew Chem Int Ed 51:5244–5246

    Article  CAS  Google Scholar 

  17. Meermann B, Sperling M (2012) Anal Bioanal Chem :1–22

  18. Timerbaev AR, Hartinger CG, Aleksenko SS, Keppler BK (2006) Chem Rev 106:2224–2248

    Article  CAS  Google Scholar 

  19. Moller C, Tastesen HS, Gammelgaard B, Lambert IH, Sturup S (2010) Metallomics 2:811–818

    Article  CAS  Google Scholar 

  20. Holding JD, Lindup WE, van Laer C, Vreeburg GC, Schilling V, Wilson JA, Stell PM (1992) Br J Clin Pharmacol 33:75–81

    Article  CAS  Google Scholar 

  21. Galanski M, Arion VB, Jakupec MA, Keppler BK (2003) Curr Pharm Des 9:2078–2089

    Article  CAS  Google Scholar 

  22. Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK (2008) Electrophoresis 29:2224–2232

    Article  CAS  Google Scholar 

  23. Lippert B (1999) Cisplatin. Chemistry and biochemistry of a leading anticancer drug. VHCA, Zürich

    Book  Google Scholar 

  24. Dickson NR, Jones SF, Burris HA, Ramanathan RK, Weiss GJ, Infante JR, Bendell JC, McCulloch W, Hoff DDV (2011) J Clin Oncol 29:abstr 2607

    Google Scholar 

  25. Shen DW, Pouliot LM, Hall MD, Gottesman MM (2012) Pharmacol Rev 64:706–721

    Article  CAS  Google Scholar 

  26. Bergamo A, Sava G (2011) Dalton Trans 40:7817–7823

    Article  CAS  Google Scholar 

  27. Mounicou S, Szpunar J, Lobinski R (2009) Chem Soc Rev 38:1119–1138

    Article  CAS  Google Scholar 

  28. Templeton DM, Ariese F, Cornelis R, Danielsson LG, Muntau H, van Leeuwen HP, Lobínski R (2000) Pure Appl Chem 72:1453–1470

    Article  CAS  Google Scholar 

  29. Shi W, Chance M (2008) Cell Mol Life Sci 65:3040–3048

    Article  CAS  Google Scholar 

  30. Esteban-Fernandez D, Moreno-Gordaliza E, Canas B, Palacios MA, Gomez-Gomez MM (2010) Metallomics 2:19–38

    Article  CAS  Google Scholar 

  31. Zayed A, Shoeib T, Taylor SE, Jones GDD, Thomas AL, Wood JP, Reid HJ, Sharp BL (2011) Int J Mass Spectrom 307:70–78

    Article  CAS  Google Scholar 

  32. Groessl M, Zava O, Dyson PJ (2011) Metallomics 3:591–599

    Article  CAS  Google Scholar 

  33. Łobiński R, Schaumlöffel D, Szpunar J (2006) Mass Spectrom Rev 25:255–289

    Article  CAS  Google Scholar 

  34. Brouwers EEM, Tibben M, Rosing H, Schellens JHM, Beijnen JH (2008) Mass Spectrom Rev 27:67–100

    Article  CAS  Google Scholar 

  35. Clarke MJ (2003) Coord Chem Rev 236:209–233

    Article  CAS  Google Scholar 

  36. Polec-Pawlak K, Abramski JK, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK, Jarosz M (2006) Electrophoresis 27:1128–1135

    Article  CAS  Google Scholar 

  37. Sulyok M, Hann S, Hartinger CG, Keppler BK, Stingeder G, Koellensperger G (2005) J Anal At Spectrom 20:856–863

    Article  CAS  Google Scholar 

  38. Groessl M, Hartinger CG, Egger A, Keppler BK (2006) The binding of ruthenium(III) anticancer complexes to serum proteins: An ESI-MS study. In: Alpoim MC, Morais PV, Santos MA, Cristóvão AJ, Centeno JA, Collery P (eds) Metal ions in biology and medicine, vol 9. Éditions John Libbey Eurotext, Montrouge, pp 111–116

    Google Scholar 

  39. Howell SB, Safaei R, Larson CA, Sailor MJ (2010) Mol Pharmacol 77:887–894

    Article  CAS  Google Scholar 

  40. Du X, Wang X, Li H, Sun H (2012) Metallomics

  41. Egger AE, Rappel C, Jakupec MA, Hartinger CG, Heffeter P, Keppler BK (2009) J Anal At Spectrom 24:51–61

    Article  CAS  Google Scholar 

  42. Centerwall CR, Tacka KA, Kerwood DJ, Goodisman J, Toms BB, Dubowy RL, Dabrowiak JC (2006) Mol Pharmacol 70:348–355

    CAS  Google Scholar 

  43. Sar DG, Montes-Bayón M, Blanco-González E, Sanz-Medel A (2010) Trends Anal Chem 29:1390–1398

    Article  CAS  Google Scholar 

  44. Brouwers E, Tibben M, Pluim D, Rosing H, Boot H, Cats A, Schellens J, Beijnen J (2008) Anal Bioanal Chem 391:577–585

    Article  CAS  Google Scholar 

  45. Esteban-Fernández D, Verdaguer JM, Ramírez-Camacho R, Palacios MA, Gómez-Gómez MM (2008) J Anal Toxicol 32:140–146

    Google Scholar 

  46. Bytzek AK, Hartinger CG (2012) Electrophoresis 33:622–634

    Article  CAS  Google Scholar 

  47. Hartinger CG, Hann S, Koellensperger G, Sulyok M, Groessl M, Timerbaev AR, Rudnev AV, Stingeder G, Keppler BK (2005) Int J Clin Pharmacol Ther 43:583–585

    CAS  Google Scholar 

  48. Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK (2006) J Inorg Biochem 100:891–904

    Article  CAS  Google Scholar 

  49. Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Dyson PJ, Keppler BK (2008) Chem Biodivers 5:1609–1614

    Article  CAS  Google Scholar 

  50. Groessl M, Bytzek A, Hartinger CG (2009) Electrophoresis 30:2720–2727

    Article  CAS  Google Scholar 

  51. Groessl M, Hartinger CG, Dyson PJ, Keppler BK (2008) J Inorg Biochem 102:1060–1065

    Article  CAS  Google Scholar 

  52. Bytzek AK, Reithofer MR, Galanski M, Groessl M, Keppler BK, Hartinger CG (2010) Electrophoresis 31:1144–1150

    Article  CAS  Google Scholar 

  53. Moller C, Sturup S, Hansen HR, Gammelgaard B (2009) J Anal At Spectrom 24:1208–1212

    Article  CAS  Google Scholar 

  54. Timerbaev AR, Aleksenko SS, Polec-Pawlak K, Ruzik R, Semenova O, Hartinger CG, Oszwaldowski S, Galanski M, Jarosz M, Keppler BK (2004) Electrophoresis 25:1988–1995

    Article  CAS  Google Scholar 

  55. Szpunar J, Makarov A, Pieper T, Keppler BK, Łobiński R (1999) Anal Chim Acta 387:135–144

    Article  CAS  Google Scholar 

  56. Groessl M, Terenghi M, Casini A, Elviri L, Lobinski R, Dyson PJ (2010) J Anal At Spectrom 25:305–313

    Article  CAS  Google Scholar 

  57. Allain P, Heudi O, Cailleux A, Le Bouil A, Larra F, Boisdron-Celle M, Gamelin E (2000) Drug Metab Dispos 28:1379–1384

    CAS  Google Scholar 

  58. Xie R, Johnson W, Rodriguez L, Gounder M, Hall G, Buckley B (2007) Anal Bioanal Chem 387:2815–2822

    Article  CAS  Google Scholar 

  59. Kasherman Y, Sturup S, Gibson D (2009) J Med Chem 52:4319–4328

    Article  CAS  Google Scholar 

  60. Perez RP (1998) Eur J Cancer 34:1535–1542

    Article  CAS  Google Scholar 

  61. Bytzek AK, Boeck K, Hermann G, Hann S, Keppler BK, Hartinger CG, Koellensperger G (2011) Metallomics 3:1049–1055

    Article  CAS  Google Scholar 

  62. Bell DN, Liu JJ, Tingle MD, McKeage MJ (2006) J Chromatogr B 837:29–34

    Article  CAS  Google Scholar 

  63. Bosch ME, Sánchez AJR, Rojas FS, Ojeda CB (2008) J Pharm Biomed Anal 47:451–459

    Article  CAS  Google Scholar 

  64. Harrington CF, Le Pla RC, Jones GDD, Thomas AL, Farmer PB (2010) Chem Res Toxicol 23:1313–1321

    Article  CAS  Google Scholar 

  65. García Sar D, Montes-Bayón M, Blanco González E, Sierra LM, Aguado L, Comendador MA, Koellensperger G, Hann S, Sanz-Medel A (2009) Anal Chem 81:9553–9560

    Article  CAS  Google Scholar 

  66. Falta T, Koellensperger G, Standler A, Buchberger W, Mader RM, Hann S (2009) J Anal At Spectrom 24:1336–1342

    Article  CAS  Google Scholar 

  67. Konz I, Fernández B, Fernández M, Pereiro R, Sanz-Medel A (2012) Anal Bioanal Chem. doi:10.1007/s00216-00012-06023-00216

  68. Moreno-Gordaliza E, Giesen C, Lazaro A, Esteban-Fernandez D, Humanes B, Canas B, Panne U, Tejedor A, Jakubowski N, Gomez-Gomez MM (2011) Anal Chem 83:7933–7940

    Article  CAS  Google Scholar 

  69. Usami N, Furusawa Y, Kobayashi K, Lacombe S, Reynaud-Angelin A, Sage E, Wu T-D, Croisy A, Guerquin-Kern J-L, Le Sech C (2008) Int J Radiat Biol 84:603–611

    Article  CAS  Google Scholar 

  70. Wedlock LE, Berners-Price SJ (2011) Aust J Chem 64:692–704

    CAS  Google Scholar 

  71. Wedlock LE, Kilburn MR, Cliff JB, Filgueira L, Saunders M, Berners-Price SJ (2011) Metallomics 3:917–925

    Article  CAS  Google Scholar 

  72. Yates JR, Ruse CI, Nakorchevsky A (2009) Annu Rev Biomed Eng 11:49–79

    Article  CAS  Google Scholar 

  73. Mendes F, Groessl M, Nazarov AA, Tsybin YO, Sava G, Santos I, Dyson PJ, Casini A (2011) J Med Chem 54:2196–2206

    Article  CAS  Google Scholar 

  74. Will J, Kyas A, Sheldrick WS, Wolters D (2007) J Biol Inorg Chem 12:883–894

    Article  CAS  Google Scholar 

  75. Will J, Sheldrick WS, Wolters D (2008) J Biol Inorg Chem 13:421–434

    Article  CAS  Google Scholar 

  76. Hartinger CG, Casini A, Duhot C, Tsybin YO, Messori L, Dyson PJ (2008) J Inorg Biochem 102:2136–2141

    Article  CAS  Google Scholar 

  77. Casini A, Karotki A, Gabbiani C, Rugi F, Vasak M, Messori L, Dyson PJ (2009) Metallomics 1:434–441

    Article  CAS  Google Scholar 

  78. Cubo L, Groessl M, Casini A, Dyson PJ, Quiroga AG, Navarro-Ranninger C (2010) ChemMedChem 5:1335–1343

  79. Lentz F, Drescher A, Lindauer A, Henke M, Hilger RA, Hartinger CG, Scheulen ME, Dittrich C, Keppler BK, Jaehde U, Re CESAD (2009) Anti-Cancer Drugs 20:97–103

    Article  CAS  Google Scholar 

  80. Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SMM, Early BP, Siuti N, LeDuc RD, Compton PD, Thomas PM, Kelleher NL (2011) Nature 480:254–258

    Article  CAS  Google Scholar 

  81. Hartinger CG, Tsybin YO, Fuchser J, Dyson PJ (2008) Inorg Chem 47:17–19

    Article  CAS  Google Scholar 

  82. Meier SM, Tsybin YO, Dyson PJ, Keppler BK, Hartinger CG (2012) Anal Bioanal Chem 402:2655–2662

    Article  CAS  Google Scholar 

  83. Zhao T, King FL (2011) J Biol Inorg Chem 16:633–639

    Article  CAS  Google Scholar 

  84. Zhao T, King FL (2010) J Inorg Biochem 104:186–192

    Article  CAS  Google Scholar 

  85. Li H, Lin TY, Van Orden SL, Zhao Y, Barrow MP, Pizarro AM, Qi Y, Sadler PJ, O'Connor PB (2011) Anal Chem 83:9507–9515

    Article  CAS  Google Scholar 

  86. Moreno-Gordaliza E, Canas B, Palacios MA, Gomez-Gomez MM (2009) Anal Chem 81:3507–3516

    Article  CAS  Google Scholar 

  87. Moreno-Gordaliza E, Canas B, Palacios MA, Gomez-Gomez MM (2010) Analyst 135:1288–1298

    Article  CAS  Google Scholar 

  88. Will J, Wolters DA, Sheldrick WS (2008) ChemMedChem 3:1696–1707

    Article  CAS  Google Scholar 

  89. Neault JF, Tajmir-Riahi HA (1998) Biochim Biophys Acta 1384:153–159

    Article  CAS  Google Scholar 

  90. Allardyce CS, Dyson PJ, Coffey J, Johnson N (2002) Rapid Commun Mass Spectrom 16:933–935

    Article  CAS  Google Scholar 

  91. Khalaila I, Allardyce CS, Verma CS, Dyson PJ (2005) ChemBioChem 6:1788–1795

    Article  CAS  Google Scholar 

  92. Appleton TG, Connor JW, Hall JR (1988) Inorg Chem 27:130–137

    Article  CAS  Google Scholar 

  93. Fröhling CDW, Sheldrick WS (1997) J Chem Soc, Dalton Trans :4411–4420

  94. Hahn M, Kleine M, Sheldrick W (2001) J Biol Inorg Chem 6:556–566

    Article  CAS  Google Scholar 

  95. Gstaiger M, Aebersold R (2009) Nat Rev Genet 10:617–627

    Article  CAS  Google Scholar 

  96. Bantscheff M, Schirle M, Sweetman G, Rick J, Kuster B (2007) Anal Bioanal Chem 389:1017–1031

    Article  CAS  Google Scholar 

  97. Simpson RJ, Bernhard OK, Greening DW, Moritz RL (2008) Curr Opin Chem Biol 12:72–77

    Article  CAS  Google Scholar 

  98. Stewart JJ, White JT, Yan X, Collins S, Drescher CW, Urban ND, Hood L, Lin B (2006) Mol Cell Proteomics 5:433–443

    CAS  Google Scholar 

  99. Fitzpatrick DP, You JS, Bemis KG, Wery JP, Ludwig JR, Wang M (2007) Proteomics Clin Appl 1:246–263

    Article  CAS  Google Scholar 

  100. Guidi F, Landini I, Puglia M, Magherini F, Gabbiani C, Cinellu MA, Nobili S, Fiaschi T, Bini L, Mini E, Messori L, Modesti A (2012) Metallomics 4:307–314

    Article  CAS  Google Scholar 

  101. Bindoli A, Rigobello MP, Scutari G, Gabbiani C, Casini A, Messori L (2009) Coord Chem Rev 253:1692–1707

    Article  CAS  Google Scholar 

  102. Stefanopoulou M, Kokoschka M, Sheldrick WS, Wolters DA (2011) Proteomics 11:4174–4188

    Article  CAS  Google Scholar 

  103. Cho Y-E, Singh TSK, Lee H-C, Moon P-G, Lee J-E, Lee M-H, Choi E-C, Chen Y-J, Kim S-H, Baek M-C (2012) Mol Cell Proteomics 11:

  104. Le Pla RC, Ritchie KJ, Henderson CJ, Wolf CR, Harrington CF, Farmer PB (2007) Chem Res Toxicol 20:1177–1182

    Article  CAS  Google Scholar 

  105. Wynne P, Newton C, Ledermann JA, Olaitan A, Mould TA, Hartley JA (2007) Br J Cancer 97:927–933

    CAS  Google Scholar 

  106. Egger AE, Hartinger CG, Ben Hamidane H, Tsybin YO, Keppler BK, Dyson PJ (2008) Inorg Chem 47:10626–10633

    Article  CAS  Google Scholar 

  107. Groessl M, Tsybin YO, Hartinger CG, Keppler BK, Dyson PJ (2010) J Biol Inorg Chem 15:677–688

    Article  CAS  Google Scholar 

  108. Ortega R, Devès G, Carmona A (2009) J R Soc Interface 6:S649–S658

    Article  CAS  Google Scholar 

  109. Fahrni CJ (2007) Curr Opin Chem Biol 11:121–127

    Article  CAS  Google Scholar 

  110. Levina A, Mitra A, Lay PA (2009) Metallomics 1:458–470

    Article  CAS  Google Scholar 

  111. Ilinski P, Lai B, Cai Z, Yun W, Legnini D, Talarico T, Cholewa M, Webster LK, Deacon GB, Rainone S, Phillips DR, Stampfl APJ (2003) Cancer Res 63:1776–1779

    CAS  Google Scholar 

  112. Hall M, Dillon C, Zhang M, Beale P, Cai Z, Lai B, Stampfl AJ, Hambley T (2003) J Biol Inorg Chem 8:726–732

    Article  CAS  Google Scholar 

  113. Shimura M, Saito A, Matsuyama S, Sakuma T, Terui Y, Ueno K, Yumoto H, Yamauchi K, Yamamura K, Mimura H, Sano Y, Yabashi M, Tamasaku K, Nishio K, Nishino Y, Endo K, Hatake K, Mori Y, Ishizaka Y, Ishikawa T (2005) Cancer Res 65:4998–5002

    Article  CAS  Google Scholar 

  114. Crossley EL, Aitken JB, Vogt S, Harris HH, Rendina LM (2010) Angew Chem Int Ed Engl 49:1231–1233

    Article  CAS  Google Scholar 

  115. Domaille DW, Que EL, Chang CJ (2008) Nat Chem Biol 4:168–175

    Article  CAS  Google Scholar 

  116. Klein AV, Hambley TW (2009) Chem Rev 109:4911–4920

    Article  CAS  Google Scholar 

  117. Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM (2006) Proc Natl Acad Sci 103:9903–9907

    Article  CAS  Google Scholar 

  118. Alderden RA, Mellor HR, Modok S, Hambley TW, Callaghan R (2006) Biochem Pharmacol 71:1136–1145

    Article  CAS  Google Scholar 

  119. Nazarov AA, Risse J, Ang WH, Schmitt F, Zava O, Ruggi A, Groessl M, Scopelitti R, Juillerat-Jeanneret L, Hartinger CG, Dyson PJ (2012) Inorg Chem 51:3633–3639

    Article  CAS  Google Scholar 

  120. Kurzwernhart A, Kandioller W, Bartel C, Bachler S, Trondl R, Muhlgassner G, Jakupec MA, Arion VB, Marko D, Keppler BK, Hartinger CG (2012) Chem Commun 48:4839–4841

    Article  CAS  Google Scholar 

  121. Danley DE (2006) Acta Crystallogr D 62:569–575

    Article  CAS  Google Scholar 

  122. Cetinbas N, Webb M, Dubland J, Walsby C (2010) J Biol Inorg Chem 15:131–145

    Article  CAS  Google Scholar 

  123. Kratz F, Keppler BK, Messori L, Smith C, Baker EN (1994) Met Based Drugs 1:169–173

    Article  CAS  Google Scholar 

  124. Smith CA, Sutherland-Smith AJ, Keppler BK, Kratz F, Baker EN (1996) J Biol Inorg Chem 1:424–431

    Article  CAS  Google Scholar 

  125. Kratz F, Hartmann M, Keppler B, Messori L (1994) J Biol Chem 269:2581–2588

    CAS  Google Scholar 

  126. Messori L, Kratz F, Alessio E (1996) Met Based Drugs 3:1–9

    Article  CAS  Google Scholar 

  127. Messori L, Vilchez FG, Vilaplana R, Piccioli F, Alessio E, Keppler B (2000) Met Based Drugs 7:335–342

    Article  CAS  Google Scholar 

  128. Pongratz M, Schluga P, Jakupec MA, Arion VB, Hartinger CG, Allmaier G, Keppler BK (2004) J Anal At Spectrom 19:46–51

    Article  CAS  Google Scholar 

  129. Ohndorf UM, Rould MA, He Q, Pabo CO, Lippard SJ (1999) Nature 399:708–712

    Article  CAS  Google Scholar 

  130. Calderone V, Casini A, Mangani S, Messori L, Orioli PL (2006) Angew Chem Int Ed 45:1267–1269

    Article  CAS  Google Scholar 

  131. Weidt SK, Mackay CL, Langridge-Smith PRR, Sadler PJ (2007) Chem Commun: 1719–1721

  132. Wu B, Davey CA (2008) Chem Biol 15:1023–1028

    Article  CAS  Google Scholar 

  133. Wu B, Droege P, Davey CA (2008) Nature Chem Biol 4:110–112

    Article  CAS  Google Scholar 

  134. Wu B, Davey GE, Nazarov AA, Dyson PJ, Davey CA (2011) Nucleic Acids Res 39:8200–8212

    Article  CAS  Google Scholar 

  135. Segal E, Fondufe-Mittendorf Y, Chen L, Thastrom A, Field Y, Moore IK, Wang J-PZ, Widom J (2006) Nature 442:772–778

    Article  CAS  Google Scholar 

  136. Wu B, Ong MS, Groessl M, Adhireksan Z, Hartinger CG, Dyson PJ, Davey CA (2011) Chemistry Eur J 17:3562–3566

    Article  CAS  Google Scholar 

  137. Neidle S (ed) (2008) Cancer: Drug design and discovery. Academic Press, New York

    Google Scholar 

  138. Debreczeni JE, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E (2006) Angew Chem Int Ed 45:1580–1585

    Article  CAS  Google Scholar 

  139. Pagano N, Maksimoska J, Bregman H, Williams DS, Webster RD, Xue F, Meggers E (2007) Org Biomol Chem 5:1218–1227

    Article  CAS  Google Scholar 

  140. Atilla-Gokcumen GE, Pagano N, Streu C, Maksimoska J, Filippakopoulos P, Knapp S, Meggers E (2008) ChemBioChem 9:2933–2936

    Article  CAS  Google Scholar 

  141. Xie P, Williams DS, Atilla-Gokcumen GE, Milk L, Xiao M, Smalley KSM, Herlyn M, Meggers E, Marmorstein R (2008) ACS Chem Biol 3:305–316

    Article  CAS  Google Scholar 

  142. Maksimoska J, Feng L, Harms K, Yi C, Kissil J, Marmorstein R, Meggers E (2008) J Am Chem Soc 130:15764–15765

    Article  CAS  Google Scholar 

  143. Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft E, Meggers E, Knapp S (2009) PLoS One 4:e7112 7111–7117

    Article  CAS  Google Scholar 

  144. Xie P, Streu C, Qin J, Bregman H, Pagano N, Meggers E, Marmorstein R (2009) Biochemistry 48:5187–5198

    Article  CAS  Google Scholar 

  145. Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kraling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen L-O, Meggers E (2011) J Am Chem Soc 133:5976–5986

    Article  CAS  Google Scholar 

  146. Atilla-Gokcumen GE, Di CL, Meggers E (2011) J Biol Inorg Chem 16:45–50

    Article  CAS  Google Scholar 

  147. Meggers E (2009) Chem Commun: 1001–1010

  148. Papayannopoulos IA (1995) Mass Spectrom Rev 14:49–73

    Article  CAS  Google Scholar 

  149. Jolly Graham A, Potti A (2009) Current Oncol Rep 11:263–268

    Article  Google Scholar 

  150. Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C, Villegas E, Jacquemont C, Farrugia DJ, Couch FJ, Urban N, Taniguchi T (2008) Nature 451:1116–1120

    Article  CAS  Google Scholar 

  151. Khrunin AV, Moisseev A, Gorbunova V, Limborska S (2009) Pharmacogenomics J 10:54–61

    Article  CAS  Google Scholar 

  152. Joerger M, Burgers J, Baas P, Doodeman V, Smits P, Jansen R, Vainchtein L, Rosing H, Huitema A, Beijnen J, Schellens J (2012) Cancer Chemother Pharmacol 69:25–33

    Article  CAS  Google Scholar 

  153. Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM (2007) J Clin Oncol 25:517–525

    Article  CAS  Google Scholar 

  154. Riedel RF, Porrello A, Pontzer E, Chenette EJ, Hsu DS, Balakumaran B, Potti A, Nevins J, Febbo PG (2008) Mol Cancer Ther 7:3141–3149

    Article  CAS  Google Scholar 

  155. Kim HK, Choi IJ, Kim CG, Kim HS, Oshima A, Michalowski A, Green JE (2011) PLoS One 6:e16694

    Article  CAS  Google Scholar 

  156. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis GR, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS (2007) Nature 447:655–660

    Article  CAS  Google Scholar 

  157. Collins F (2010) Nature 464:674–675

    Article  CAS  Google Scholar 

  158. Marshall E (2011) Science 331:526–529

    Article  CAS  Google Scholar 

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Acknowledgments

CGH is grateful for financial support from the University of Auckland, the Austrian Science Fund and the Johanna Mahlke geb. Obermann Foundation. The authors acknowledge financial support from the University of Vienna, the Austrian Science Fund (FWF), and the COST actions D39, CM1105 and CM0902.

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Authors and Affiliations

  1. Institute of Analytical Chemistry, University of Vienna, Waehringer Str. 42, 1090, Vienna, Austria

    Michael Groessl

  2. School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand

    Christian G. Hartinger

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  1. Michael Groessl
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  2. Christian G. Hartinger
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Correspondence to Michael Groessl.

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Published in the topical collection Metallomics with guest editors Uwe Karst and Michael Sperling.

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Groessl, M., Hartinger, C.G. Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends. Anal Bioanal Chem 405, 1791–1808 (2013). https://doi.org/10.1007/s00216-012-6450-4

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  • DOI: https://doi.org/10.1007/s00216-012-6450-4

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