Skip to main content
Log in

ProSafeBeef and anthelmintic drug residues—a case study in collaborative application of multi-analyte mass spectrometry to enhance consumer safety

  • Feature Article
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. European Commission (2010) Commission Regulation (EC) 37/2010, of 22 December 2010 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off J Eur Communities L15:1–72

    Google Scholar 

  2. European Commission (1996) Council Directive 96/23/EC, of 29 April 1996, on measures to monitor certain substances and residues thereof in live animals and animal products. Off J Eur Communities L125:10–32

    Google Scholar 

  3. Osei-Atweneboana MY, Eng JKL, Boakye DA, Gyapong JO, Prichard RK (2007) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study. Lancet 369:2021–2029

    Article  Google Scholar 

  4. Winkelhagen AJS, Mank T, de Vries PJ, Soetekouw R (2012) Apparent triclabendazole-resistant human Fasciola hepatica infection, the Netherlands [letter]. Emerg Infect Dis 18:1028–1029. doi:10.3201/eid1806.111038 [serial on the Internet]

    Article  Google Scholar 

  5. Fairweather I (2011) Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy? Vet Parasitol 180:133–143

    Article  Google Scholar 

  6. Danaher M, De Ruyck H, Crooks SRH, Dowling G, O’Keeffe M (2007) Review of methodology for the determination of benzimidazole residues in biological matrices. J Chromatogr B 845:1–37

    Article  CAS  Google Scholar 

  7. Danaher M, Howells LC, Crooks SRH, Cerkvenik-Flajs V, O’Keeffe M (2006) Review of methodology for the determination of macrocyclic lactone residues in biological matrices. J Chromatogr B 844:175–203

    Article  CAS  Google Scholar 

  8. Danaher M, Radeck W, Kolar L, Keegan J, Cerkvenik-Flajs V (2012) Recent developments in the analysis of avermectin and milbemycin residues in food safety and the environment. Curr Pharm Biotechnol 13:936–951

    CAS  Google Scholar 

  9. Kinsella B, Lehotay SJ, Mastovska K, Lightfield AR, Furey A, Danaher M (2009) New method for the analysis of flukicide and other anthelmintic residues in bovine milk and liver using liquid chromatography–tandem mass spectrometry. Anal Chim Acta 637:196–207

    Article  CAS  Google Scholar 

  10. Lehotay S, de Kok A, Hiemstra M, van Bodegraven P (2005) Validation of a fast and easy method for the determination of residues from 229 pesticides in fruits and vegetables using gas and liquid chromatography and mass spectrometric detection. J AOAC Int 88:595–614

    CAS  Google Scholar 

  11. Whelan M, Kinsella B, Furey A, Moloney M, Cantwell H, Lehotay SJ, Danaher M (2010) Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography–tandem mass spectrometry with rapid polarity switching. J Chromatogr A 1217:4612–4622

    Article  CAS  Google Scholar 

  12. Kinsella B, Whelan M, Cantwell H, McCormack M, Furey A, Lehotay SJ, Danaher M (2010) A dual validation approach to detect anthelmintic residues in bovine liver over an extended concentration range. Talanta 83:14–24

    Article  CAS  Google Scholar 

  13. Cooper KM, Whelan M, Kennedy DG, Trigueros G, Cannavan A, Boon P, Wapperom D, Danaher M (2012) Anthelmintic drug residues in beef – UPLC–MS–MS method validation, European retail survey and risk assessment. Food Addit Contam A 29:746–760

    Article  CAS  Google Scholar 

  14. European Commission (2002) Commission Decision 2002/657/EC, of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Communities L221:8–36

    Google Scholar 

  15. Van Wezemael L, Verbeke W, Kugler JO, De Barcellos MD, Grunert KG (2010) European consumers and beef safety: Perceptions, expectations and uncertainty reduction strategies. Food Control 21:835–844

    Article  Google Scholar 

  16. Rose MD, Rowley L, Shearer G et al (1997) Effect of cooking on veterinary drug residues in food.6. Lasalocid. J Agric Food Chem 45:927–930

    Article  CAS  Google Scholar 

  17. Cooper KM, Whelan M, Danaher M, Kennedy DG (2011) Stability during cooking of anthelmintic veterinary drug residues in beef. Food Addit Contam A 28:155–165

    Article  CAS  Google Scholar 

  18. Cooper KM, Whyte M, Danaher M, Kennedy DG (2012) Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle. Food Addit Contam A 29:1263–1271

    Article  CAS  Google Scholar 

  19. Kennedy DG, Shortt HD, Crooks SRH, Young PB, Price HJ, Smyth WG, Hewitt SA (2009) Occurrence of α- and β-nortestosterone residues in the urine of injured male cattle. Food Addit Contam A 26:683–691

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kevin M. Cooper.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cooper, K.M., Kennedy, D.G. & Danaher, M. ProSafeBeef and anthelmintic drug residues—a case study in collaborative application of multi-analyte mass spectrometry to enhance consumer safety. Anal Bioanal Chem 404, 1623–1630 (2012). https://doi.org/10.1007/s00216-012-6310-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-012-6310-2

Navigation