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A CMOS image sensor to recognize the cardiovascular disease markers troponin I and C-reactive protein

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Abstract

A complementary metal oxide semiconductor (CMOS) image sensor was utilized to detect the interaction of cardiovascular disease markers, troponin I and C-reactive protein. Each marker with its respective antibodies was adsorbed to an indium nanoparticle (InNP)-coated glass substrate. Dielectric layers of antigens and antibodies bound onto and interacted on conducting InNPs. Normal room light passed through these protein-layer-bound substrates and hit the CMOS image sensor surface, and the number of photons was detected and converted into digital form. We tested this approach for real-time monitoring of cardiac disease markers based on photon count, demonstrating its low cost and its capacity to detect antigens with high sensitivity at picogram per milliliter concentration.

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Acknowledgement

This work was supported by the WCU Program (R33-2010-000-10067-0) of Korean Ministry of Education & Science Technology and further supported by the Industrial Strategic Technology Development Program (10035197) funded by the Ministry of Knowledge Economy of Korea and by the Public welfare & Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0021115).

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Authors and Affiliations

  1. College of Bionanotechnology, Kyungwon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, 461-701, Korea

    Jasmine Pramila Devadhasan, Mohana Marimuthu & Sanghyo Kim

  2. Graduate Program of Photonics and Applied Physics and Advanced Photonics Research Institute, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea

    Min-Gon Kim

Authors
  1. Jasmine Pramila Devadhasan
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  2. Mohana Marimuthu
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  3. Sanghyo Kim
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  4. Min-Gon Kim
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Corresponding authors

Correspondence to Sanghyo Kim or Min-Gon Kim.

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Devadhasan, J.P., Marimuthu, M., Kim, S. et al. A CMOS image sensor to recognize the cardiovascular disease markers troponin I and C-reactive protein. Anal Bioanal Chem 402, 813–821 (2012). https://doi.org/10.1007/s00216-011-5478-1

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  • DOI: https://doi.org/10.1007/s00216-011-5478-1

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