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Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples

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Abstract

A novel method based on three-phase hollow fiber microextraction technique (HF-LPME) coupled with electrospray ionization-ion mobility spectrometry (ESI-IMS) was developed for the simultaneous determination of two antidepressant drugs (trimipramine and desipramine) in urine and plasma samples. The effects of various parameters such as type of organic solvent, composition of donor and acceptor phase, stirring rate, salt addition, extraction time, and temperature were investigated. Under the optimized conditions, the relative standard deviation was in the range of 5–6%, and the method quantitation limit (MQL) of utilizing HF-LPME/ESI-IMS was 5 μg/L for both drugs. The relative recoveries obtained by the proposed method from urine and plasma samples were in the range 94% to 97% for trimipramine and 92% to 96% for desipramine. Finally, the feasibility of the proposed method was successfully confirmed by extraction and determination of trace amounts of trimipramine and desipramine in biological samples without any significant matrix effect.

Schematic presentation of the electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique

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References

  1. Wang J, Bonakdar M, Morgan C (1986) Anal Chem 58:1024–1028

    Article  CAS  Google Scholar 

  2. Reynolds JL, Ignatowski TA, Sud R, Spengler RN (2005) J Neurosci 133:519–531

    Article  CAS  Google Scholar 

  3. Kerr GW, Mcguffie AC, Wilkie S (2001) J Emerg Med 18:236–241

    Article  CAS  Google Scholar 

  4. Gangolli S (1999) The dictionary of substances and their effects, 2nd edn. RSC, UK

    Book  Google Scholar 

  5. Kataoka H (2010) Anal Bioanal Chem 396:339–364

    Article  CAS  Google Scholar 

  6. Theurillat R, Thormann W (1998) J Pharm Biomed 18:751–760

    Article  CAS  Google Scholar 

  7. Lajeunesse A, Gagnon C, Sauve S (2008) Anal Chem 80:5325–5333

    Article  CAS  Google Scholar 

  8. Chaves AR, Junior GC, Queiroz MEC (2009) J Chromatogr B 877:587–593

    Article  CAS  Google Scholar 

  9. Chaves AR, Silva SM, Queiroz RHC, Lancas FM, Queiroz MEC (2007) J Chromatogr B 850:295–302

    Article  CAS  Google Scholar 

  10. Hansson H, Nilsson U (2009) Talanta 77:1309–1314

    Article  CAS  Google Scholar 

  11. Ebrahimzadeh H, Yamini Y, Kamarei F, Khalili-Zanjani M (2007) Talanta 72:193–198

    Article  CAS  Google Scholar 

  12. Saraji M, Hajialiakbari AA (2010) Anal Bioanal Chem 397:3107–3115

    Article  CAS  Google Scholar 

  13. Loughrin JH (2006) J Agric Food Chem 54:3237–3241

    Article  CAS  Google Scholar 

  14. Rodriguez A, Pedersen-Bjergaard S, Rasmussen KE, Nerin C (2008) J Chromatogr A 1198–1199:38–44

    Article  Google Scholar 

  15. Lambropoulou DA, Albanis TA (2005) J Chromatogr A 1072:55–61

    Article  CAS  Google Scholar 

  16. Eap CB, Koeb L, Baumann P (1994) J Chromatogr B 652:97–103

    Article  CAS  Google Scholar 

  17. Pommier F, Sioufi A, Godbillon J (1997) J Chromatogr B 703:147–158

    Article  CAS  Google Scholar 

  18. Madej K, Kochana J, Woniakiewicz M (2007) J Liq Chromatogr RT 30:185–198

    Article  CAS  Google Scholar 

  19. Reece PA, Zacest R (1979) J Chromatogr 163:310–314

    Article  CAS  Google Scholar 

  20. Balikova M (1992) J Chromatogr 581:75–81

    Article  CAS  Google Scholar 

  21. Ivandini TA, Sarada BV, Terashima C, Rao TN, Tryk DA, Ishiguro H (2002) J Electroanal Chem 521:117–126

    Article  CAS  Google Scholar 

  22. Kirchherr H, Kuhn-Velten WN (2006) J Chromatogr B 843:100–113

    Article  CAS  Google Scholar 

  23. Karasek FW (1974) Anal Chem 46:710A–720A

    Article  CAS  Google Scholar 

  24. Eiceman GA, Karpas Z (2005) Ion mobility spectrometry, 2nd edn. CRC, Boca Raton

    Book  Google Scholar 

  25. Saraji M, Jafari MT, Sherafatmand H (2010) J Chromatogr A 1217:5173–5178

    Article  CAS  Google Scholar 

  26. Jafari MT (2009) Talanta 77:1632–1639

    Article  CAS  Google Scholar 

  27. Lord H, Pawliszyn J (2000) J Chromatogr A 902:17–63

    Article  CAS  Google Scholar 

  28. Bakkali A, Corta E, Ciria JI, Berrueta LA, Gallo B, Vicente F (1999) Talanta 49:773–783

    Article  CAS  Google Scholar 

  29. Ulrich S, Martens J (1997) J Chromatogr B 696:217–234

    Article  CAS  Google Scholar 

  30. Misiuk W (2000) J Pharm Biomed 22:189–196

    Article  CAS  Google Scholar 

  31. Jinno K, Kawazoe M, Saito Y, Takeichi T, Hayashida M (2001) Electrophoresis 22:3785–3790

    Article  CAS  Google Scholar 

  32. Halvorsen TG, Pedersen-Bjergaard S, Reubsaet JLE, Rasmussen KE (2003) J Sep Sci 26:1520–1526

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The authors wish to express their gratitude to the Center of Excellence for Sensors and Green Chemistry, Isfahan University of Technology (IUT), Iran, for the financial support.

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Authors and Affiliations

  1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    M. T. Jafari, M. Saraji & H. Sherafatmand

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  1. M. T. Jafari
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  2. M. Saraji
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  3. H. Sherafatmand
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Correspondence to M. T. Jafari.

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Jafari, M.T., Saraji, M. & Sherafatmand, H. Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Anal Bioanal Chem 399, 3555–3564 (2011). https://doi.org/10.1007/s00216-011-4730-z

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  • DOI: https://doi.org/10.1007/s00216-011-4730-z

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