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How to design cell-based biosensors using the sol–gel process

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Abstract

Inorganic gels formed using the sol–gel process are promising hosts for the encapsulation of living organisms and the design of cell-based biosensors. However, the possibility to use the biological activity of entrapped cells as a biological signal requires a good understanding and careful control of the chemical and physical conditions in which the organisms are placed before, during, and after gel formation, and their impact on cell viability. Moreover, it is important to examine the possible transduction methods that are compatible with sol–gel encapsulated cells. Through an updated presentation of the current knowledge in this field and based on selected examples, this review shows how it has been possible to convert a chemical technology initially developed for the glass industry into a biotechnological tool, with current limitations and promising specificities.

Optical fluorescence image of living bacteria in silica thin films

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Acknowledgement

The postdoctoral grant for C.D. was funded by the E!4289 Silibacts project from the Eurostars program.

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Authors and Affiliations

  1. UPMC Univ Paris 6; CNRS, Chimie de la Matière Condensée de Paris, Collège de France, 75005, Paris, France

    Christophe Depagne, Cécile Roux & Thibaud Coradin

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  1. Christophe Depagne
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  2. Cécile Roux
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  3. Thibaud Coradin
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Corresponding author

Correspondence to Thibaud Coradin.

Additional information

Published in the special issue Microorganisms for Analysis with Guest Editor Gérald Thouand.

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Depagne, C., Roux, C. & Coradin, T. How to design cell-based biosensors using the sol–gel process. Anal Bioanal Chem 400, 965–976 (2011). https://doi.org/10.1007/s00216-010-4351-y

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