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Trimethylsilyldiazomethane (TMSD) as a new derivatization reagent for trace analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) by gas chromatography methods

Analytical and Bioanalytical Chemistry volume 397, pages 3029–3034 (2010)Cite this article

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common groups of pharmaceuticals detected in environmental matrices. Although several derivatization procedures have been employed in the gas chromatographic analysis of NSAIDs, the application of trimethylsilyldiazomethane has never yet been reported. This work has studied the derivatization of widely used NSAIDs (ibuprofen, ketoprofen and naproxen) by trimethylsilyldiazomethane. Special emphasis was placed on the influence of temperature and reaction time on the reaction yield, and on the determination of the instrumental detection limit. The results are compared with those obtained by methylation using boron trifluoride methanol solution, and by silylation with a mixture of N,O-bis(trimethylsilyl)trifluoroacetamide and trimethylchlorosilane (99:1, v/v) and with N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide. The derivatization of ibuprofen, ketoprofen and naproxen by trimethylsilyldiazomethane was shown to be simple, fast, efficient, and suitable for trace analysis (the respective instrumental detection limits for ibuprofen naproxen, and ketoprofen were 2, 4, and 4 ng). Trimethylsilyldiazomethane can be used as an alternative reagent for determining acidic drugs in environmental matrices.

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Acknowledgment

Financial support was provided by the Polish Ministry of Research and Higher Education under grants NN204 260 237 and DS 8200-4-0085-0.

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Authors and Affiliations

  1. Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Sobieskiego 18/19, 80-952, Gdańsk, Poland

    Natalia Migowska, Piotr Stepnowski, Monika Paszkiewicz, Marek Gołębiowski & Jolanta Kumirska

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  1. Natalia Migowska
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  2. Piotr Stepnowski
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  3. Monika Paszkiewicz
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  5. Jolanta Kumirska
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Correspondence to Jolanta Kumirska.

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Migowska, N., Stepnowski, P., Paszkiewicz, M. et al. Trimethylsilyldiazomethane (TMSD) as a new derivatization reagent for trace analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) by gas chromatography methods. Anal Bioanal Chem 397, 3029–3034 (2010). https://doi.org/10.1007/s00216-010-3853-y

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  • DOI: https://doi.org/10.1007/s00216-010-3853-y

Keywords

  • NSAIDs
  • Gas chromatography
  • Derivatization
  • Trimethylsilyldiazomethane
  • Pharmaceutical residues