Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance
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Raman spectroscopy, X-ray powder diffraction/X-ray crystallography and differential scanning calorimetry have been used to study the phenomenon of co-crystal formation in stoichiometric mixtures of salicylic acid with benzamide. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the co-crystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon co-crystal formation, but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon co-crystal formation. Several new vibrational bands were identified in the co-crystal which were not manifested in the physical mixture of both components and could be used as diagnostic features of co-crystal formation.
KeywordsCo-crystals Raman spectroscopy DSC Salicylic acid Benzamide Hydrogen bonding
Additional Information Available
X-ray crystallographic information for the crystal structures (PDF); this material is available free of charge via the Internet at http://pubs.acs.org. Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication nos. CCDC-756492. Copies of available material can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: + 44 (0) 1223-336033 or e mail: firstname.lastname@example.org).
- 3.Peterson ML, Hickey MB, Zaworotko MJ, Almarsson O (2006) J Pharm Pharmaceut Sci 9:317–326Google Scholar
- 5.Atwood JL, Davies JED, MacNicol DD, Vogtle F (1996) Comprehensive supramolecular chemistry, vol 9. Pergamon, OxfordGoogle Scholar
- 6.Bond AD, Jones W (2002) Supramolecular organization and materials design. Cambridge University Press, CambridgeGoogle Scholar
- 7.Desiraju GR (1989) Crystal engineering: the design of organic solids. Elsevier, New YorkGoogle Scholar
- 35.Kniseley RN, Fassel VA, Farquhar EL, Gray LS (1962) Spectrochim Acta 18:1217–1229Google Scholar
- 36.Smith BC (1998) Infrared spectral interpretation: a systematic approach. CRC, Boca RatonGoogle Scholar