Analytical and Bioanalytical Chemistry

, Volume 397, Issue 1, pp 137–146 | Cite as

Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance

  • M. A. Elbagerma
  • H. G. M. Edwards
  • T. Munshi
  • I. J. Scowen
Original Paper

Abstract

Raman spectroscopy, X-ray powder diffraction/X-ray crystallography and differential scanning calorimetry have been used to study the phenomenon of co-crystal formation in stoichiometric mixtures of salicylic acid with benzamide. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the co-crystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon co-crystal formation, but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon co-crystal formation. Several new vibrational bands were identified in the co-crystal which were not manifested in the physical mixture of both components and could be used as diagnostic features of co-crystal formation.

Keywords

Co-crystals Raman spectroscopy DSC Salicylic acid Benzamide Hydrogen bonding 

Notes

Additional Information Available

X-ray crystallographic information for the crystal structures (PDF); this material is available free of charge via the Internet at http://pubs.acs.org. Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication nos. CCDC-756492. Copies of available material can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: + 44 (0) 1223-336033 or e mail: teched@chemcrys.cam.ac.uk).

Supplementary material

216_2009_3375_MOESM1_ESM.pdf (450 kb)
ESM 1 (PDF 450 kb)

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • M. A. Elbagerma
    • 1
  • H. G. M. Edwards
    • 1
  • T. Munshi
    • 1
  • I. J. Scowen
    • 1
  1. 1.Raman Spectroscopy Group, Division of Chemical and Forensic SciencesUniversity Analytical CentreBradfordUK

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