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Degradation kinetics of the Alternaria mycotoxin tenuazonic acid in aqueous solutions

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Abstract

The degradation kinetics of the Alternaria mycotoxin tenuazonic acid (l-TA) in aqueous buffer were studied over a period of 4 months at different pH levels (3.5 and 7.0) and temperatures (4, 25 and 40 °C). l-TA and its degradation products were quantified by newly developed high-performance liquid chromatography methods with UV or electrospray multistage mass spectrometry detection. At pH 3.5, significant degradation occurred at 25 and 40 °C, the respective l-TA half-lives being 73.8 ± 0.4 and 14.0 ± 0.1 days. Two degradation processes, epimerization and hydrolysis, were evaluated kinetically. The hydrolytically formed iso-deacetyl TA (iso-DTA, epimeric mixture) was found to be the stable end product of l-TA degradation under the conditions of this study. This indicates that iso-DTA as well as the l-TA epimer u-TA are formed in aqueous beverage matrices.

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Acknowledgements

The authors would like to thank Dr. Christian Piechotta, Robert Rothe and Sebastian Schmidt (all BAM, Berlin) for valuable discussion.

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Authors and Affiliations

  1. Division I.2, Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Straße 11, 12489, Berlin, Germany

    David Siegel, Stefan Merkel, Wolfram Bremser, Matthias Koch & Irene Nehls

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  1. David Siegel
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  2. Stefan Merkel
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  3. Wolfram Bremser
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  4. Matthias Koch
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  5. Irene Nehls
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Correspondence to David Siegel.

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Siegel, D., Merkel, S., Bremser, W. et al. Degradation kinetics of the Alternaria mycotoxin tenuazonic acid in aqueous solutions. Anal Bioanal Chem 397, 453–462 (2010). https://doi.org/10.1007/s00216-009-3288-5

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  • DOI: https://doi.org/10.1007/s00216-009-3288-5

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