Analytical and Bioanalytical Chemistry

, Volume 396, Issue 1, pp 339–364 | Cite as

Recent developments and applications of microextraction techniques in drug analysis

Review

Abstract

Sample preparation is important for isolating desired components from complex matrices and greatly influences their reliable and accurate analysis. Recent trends in sample preparation include miniaturization, automation, high-throughput performance, online coupling with analytical instruments, and low-cost operation through extremely low or no solvent consumption. Microextraction techniques, such as liquid-phase microextraction and solid-phase microextraction, have these advantages over the traditional approaches of liquid–liquid extraction and conventional solid-phase extraction. This review focuses primarily on these microextraction techniques developed over the last decade, and presents a summary of the characteristics of various approaches in drug analysis.

Keywords

Sample preparation Liquid-phase microextraction Single-drop microextraction Solid-phase microextraction In-tube solid-phase microextraction Drug analysis 

Abbreviations

ADS

alkyl diol silica

CE

capillary electrophoresis

DI

direct immersion

DVB

divinylbenzene

FNME

fiber-packed-needle microextraction

GC

gas chromatography

HF

hollow fiber

HPLC

high-performance liquid chromatography

HS

headspace

LC

liquid chromatography

LLE

liquid–liquid extraction

LPME

liquid-phase microextraction

MEPS

microextraction in a packed syringe

MIP

molecularly imprinted polymer

MS

mass spectrometry

PDMS

poly(dimethylsiloxane)

PEEK

polyetheretherketone

PPY

polypyrrole

PVDF

poly(vinylidene fluoride)

RAM

restricted access material

SBSE

stir-bar sorptive extraction

SDME

single-drop microextraction

SPDE

solid-phase dynamic extraction

SPE

solid-phase extraction

SPME

solid-phase microextraction

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.School of PharmacyShujitsu UniversityNishigawara, OkayamaJapan

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