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Analysis of antibiotics in fish samples

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Abstract

The use of antibiotics in food-producing animals has generated considerable interest because the widespread administration of these drugs may lead to the development of resistant human pathogens. A large increase in the demand for seafood products has occurred in the last century. This has led to a concomitant increase in high-intensity aquaculture methods, characterized by high stock density and volume, and the heavy use of formulated feeds containing antibiotics, among other substances. Therefore, accurate and sensitive determination of antibiotic residues is now a necessity. In order to protect human health, the European Union and other regulatory authorities worldwide have established maximum residue limits (MRL) for antibiotic residues in animal products entering the human food chain. This paper reviews the most recent methods for analysis of antibiotic residues in fish.

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References

  1. Landau M (1992) Introduction to aquaculture. John Wiley and Sons, New York

    Google Scholar 

  2. Bardach JE, Ryther JH, McLarney WO (1972) Aquaculture 868–875

  3. Sapkota A, Sapkota AR, Kucharski M, Burke J, McKenzie S, Walker P, Lawrence R (2008) Environ Int 34:1215–1226

    Article  Google Scholar 

  4. Hernández Serrano P (2005) Responsible use of antibiotics in aquaculture. FAO, Rome

    Google Scholar 

  5. http://www.who.int/mediacentre/factsheets/fs194/en

  6. Cabello FC (2006) Environ Microbiol 8:1137–1144

    Article  CAS  Google Scholar 

  7. Fortt A, Cabello F, Buschmann A (2007) Rev Chil Infect 24:14–18

    Google Scholar 

  8. Bobbitt DR, Ng KW (1992) J Chromatogr A 624:153–170

    Article  CAS  Google Scholar 

  9. Niessen WMA (1998) J Chromatogr A 812:53–75

    Article  CAS  Google Scholar 

  10. Di Corcia A, Nazzari M (2002) J Chromatogr A 974:53–89

    Article  Google Scholar 

  11. Horie M, Takegami H (2006) J Mass Spectrom Soc Jpn 54:91–96

    CAS  Google Scholar 

  12. Balizs G, Hewitt A (2003) Anal Chim Acta 492:105–131

    Article  CAS  Google Scholar 

  13. Stubbings G, Tarbin J, Cooper A, Sharman M, Bigwood T, Robb P (2005) Anal Chim Acta 547:262–268

    Article  CAS  Google Scholar 

  14. Blasco C, Torres CM, Picó Y (2007) Trends Anal Chem 26:895–913

    Article  CAS  Google Scholar 

  15. Samanidou V, Evaggelia F, Evaggelopoulou N (2007) J Sep Sci 30:2549–2569

    Article  CAS  Google Scholar 

  16. Stolker AAM, Brinkman UAT (2005) J Chromatogr A 1067:15–33

    Article  CAS  Google Scholar 

  17. Stolker AAM, Zuidema T, Nielen MWF (2007) Trends Anal Chem 26:967–979

    Article  CAS  Google Scholar 

  18. Castro-Puyana M, Crego AL, Marina ML (2008) Electrophoresis 29:274–293

    Article  CAS  Google Scholar 

  19. Samuelsen OB (2006) Aquaculture 255:55–75

    Article  CAS  Google Scholar 

  20. Andreu V, Blasco C, Picó Y (2007) Trends Anal Chem 26:534–556

    Article  CAS  Google Scholar 

  21. Wang S, Zhang HY, Wang L, Duan ZJ, Kennedy I (2006) Food Addit Contam 23:362–384

    Article  CAS  Google Scholar 

  22. Stead DA (2000) J Chromatogr B 747:69–93

    Article  CAS  Google Scholar 

  23. McGlinchey TA, Rafter PA, Regan F, McMahon GP (2008) Anal Chim Acta 624:1–15

    Article  CAS  Google Scholar 

  24. European Commission, Council Regulation 2377/90/EC, Off. J. Eur. Union, L224 (18 August 1990) (Consolidated version of the Annexes I to IV updated up to 20.01.2008 obtained from www.emea.eu.int)

  25. Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues there of in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decisions 89/18/EEC and 91/664/EEC, Off. J. Eur. Commun. L125 (1996) 10

  26. European Commission, Council Directive 96/22/EC of 29 April 1996 concerning the prohibition on the use in stock farming of certain substances having a hormonal or thyrostatic action and of beta-agonists, and repealing Directives 81/602/EEC, 88/146/EED and 88/299/EEC, Off. J. Eur. Union, L125 (23 May 1996) 3

  27. http://www.codexalimentarius.net/mrls/vetdrugs/jsp/vetd_q-e.jsp

  28. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=556

  29. http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/vet/mrl-lmr_versus_new-nouveau-eng.pdf

  30. http://www.apvma.gov.au/residues/downloads/table01.pdf

  31. http://www.tecnoalimentos.cl/

  32. Commission Decision 2002/657/EC of 12 August 2002 implementing Council Directive 96/23/EC concerning to the performance of analytical methods and the implementation of the results (Text with EEA relevance), Off. J. Eur. Commun. L221 (2002)

  33. Commission Decision 2003/181/EC of 13 March 2003 amending Decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin (Text with EEA relevance), Off. J. Eur. Commun. L71 (2003) 17

  34. Ramirez AJ, Mottaleb MA, Brooks BW, Chambliss CK (2007) Anal Chem 79:3155–3163

    Article  CAS  Google Scholar 

  35. Romero-Gonzalez R, Lopez-Martinez JC, Gomez-Milan E, Garrido-Frenich A, Martinez-Vidal JL (2007) J Chromatogr B Anal Technol Biomed Life Sci 857:142–148

    Article  CAS  Google Scholar 

  36. Gonzalez LS, Spencer JP (1998) Am Fam Physician 58:1811–1820

    Google Scholar 

  37. http://en.wikipedia.org/wiki/Aminoglycoside

  38. Kaufmann A, Maden K (2005) J AOAC Int 88:1118–1125

    CAS  Google Scholar 

  39. http://en.wikipedia.org/wiki/Chloramphenicol

  40. Pfenning AP, Roybal JE, Rupp HS, Turnipseed SB, Gonzalez SA, Hurlbut JA (2000) J AOAC Int 83:26–30

    CAS  Google Scholar 

  41. Vue C, Schmidt LJ, Stehly GR, Gingerich WH (2002) J Chromatogr B: Anal Technol Biomed Life Sci 780:111–117

    Article  CAS  Google Scholar 

  42. Mottier P, Parisod V, Gremaud E, Guy PA, Stadler RH (2003) J Chromatogr A 994:75–84

    Article  CAS  Google Scholar 

  43. Hammack W, Carson MC, Neuhaus BK, Hurlbut JA, Nochetto C, Stuart JS, Brown A, Kilpatrick D, Youngs K, Ferbos K, Heller DN (2003) J AOAC Int 86:1135–1143

    CAS  Google Scholar 

  44. Takino M, Daishima S, Nakahara T (2003) J Chromatogr A 1011:67–75

    Article  CAS  Google Scholar 

  45. Ding SY, Shen JZ, Zhang SX, Jiang HY, Sun ZW (2005) J AOAC Int 88:57–60

    CAS  Google Scholar 

  46. Gikas E, Kormali P, Tsipi D, Tsarbopoulos A (2004) J Agric Food Chem 52:1025–1030

    Article  CAS  Google Scholar 

  47. Shen HY, Jiang HL (2005) Anal Chim Acta 535:33–41

    Article  CAS  Google Scholar 

  48. Wrzesinski CL, Crouch LS, Endris R (2003) J AOAC Int 86:515–520

    CAS  Google Scholar 

  49. Hayes JM (2005) J AOAC Int 88:1777–1783

    CAS  Google Scholar 

  50. Wrzesinski C, Crouch L, Gaunt P, Holifield D, Bertrand N, Endris R (2006) Aquaculture 253:309–316

    Article  CAS  Google Scholar 

  51. Zhang SX, Sun FY, Li JC, Cheng LL, Shen JZ (2006) J AOAC Int 89:1437–1442

    CAS  Google Scholar 

  52. Carlucci G (1998) J Chromatogr A 812:343–367

    Article  CAS  Google Scholar 

  53. Jackson LC, Machado LA, Hamilton ML (1998) Acta Medica 8:5–8

    Google Scholar 

  54. Juan-García A, Font G, Picó Y (2006) Electrophoresis 27:2240–2249

    Article  Google Scholar 

  55. Durán Merás I, Galeano Diaz T, Salinas F, Rodriguez Cáceres MI (2000) Chromatographia 51:163–166

    Article  Google Scholar 

  56. Hormazabal V, Yndestad M (2001) J Liquid Chromatogr Related Technologies 24:109–115

    Article  CAS  Google Scholar 

  57. Pouliquen H, Morvan ML (2002) Food Addit Contam 19:223–231

    Article  CAS  Google Scholar 

  58. Roudaut B, Yorke JC (2002) J Chromatogr B 780:481–485

    Article  CAS  Google Scholar 

  59. Roybal JE, Walker CC, Pfenning AP, Turnipseed SB, Storey JM, Gonzales SA, Hurlbut JA (2002) J AOAC 85:1293–1301

    CAS  Google Scholar 

  60. Ramos M, Aranda A, Garcia E, Reuvers T, Hooghuis H (2003) J Chromatogr B 789:373–381

    Article  CAS  Google Scholar 

  61. Verdon E, Couedor P, Roudaut B, Sanders P (2005) J AOAC Int 88:1179–1192

    CAS  Google Scholar 

  62. Kirbis A, Marinsek J, Flajs VC (2005) Biomed Chromatogr 19:259–265

    Article  CAS  Google Scholar 

  63. Pouliquen H, Le-Bris H, Larhantec-Verdier M, Morvan ML (2006) Acta Chromatogr 17:173–187

    CAS  Google Scholar 

  64. Espinosa-Mansilla A, de la Muñoz Peña A, Cañada-Cañada F (2006) CTC Alimentación 30:10–14

    Google Scholar 

  65. Johnston L, Mackay L, Croft M (2002) J Chromatography A 982:97–109

    Article  CAS  Google Scholar 

  66. Turnipseed SB, Roybal JE, Pfenning AP, Kijak PJ (2003) Anal Chim Acta 483:373–386

    Article  CAS  Google Scholar 

  67. Schneider MJ, Vazquez-Moreno L, Bermudez-Almada MC, Guardado RB, Ortega-Nieblas M (2005) J AOAC Int 88:1160–1166

    CAS  Google Scholar 

  68. Karbiwnyk CM, Carr LE, Turnipseed SB, Andersen WC, Miller KE (2007) Anal Chim Acta 596:257–263

    Article  CAS  Google Scholar 

  69. Hernando MD, Mezcua M, Suarez-Barcena JM, Fernandez-Alba AR (2006) Anal Chim Acta 562:176–184

    Article  CAS  Google Scholar 

  70. Dufresne G, Fouquet A, Forsyth D, Tittlemier SA (2007) J AOAC Int 90:604–612

    CAS  Google Scholar 

  71. Samanidou V, Evaggelopoulou E, Trötzmüller M, Guo X, Lankmayr E (2008) J Chromatogr A 120:115–123

    Article  Google Scholar 

  72. http://en.wikipedia.org/wiki/Macrolide

  73. Horie M, Takegami H, Toya K, Nakazawa H (2003) Anal Chim Acta 492:187–197

    Article  CAS  Google Scholar 

  74. Lucchetti D, Fabrizi L, Esposito A, Guandalini E, di-Pasquale M, Coni E (2005) J Agric Food Chem 53:9689–9694

    Article  CAS  Google Scholar 

  75. Houda Berrada F, Borrull G, Font RM (2008) J Chromatogr, A 1208:83–89

    Article  Google Scholar 

  76. Connely A, Nugent A, O'Keeffe M (2002) Analyst 127:705–709

    Article  Google Scholar 

  77. Ge BK, Wang YF, Chang CY, Zuo GH (2003) Fenxi-Ceshi-Xuebao 22:91–93

    CAS  Google Scholar 

  78. Edder P, Vargas S, Ortelli D, Corvi C (2003) Clin Chem Lab Med 41:1608–1614

    Article  CAS  Google Scholar 

  79. Chu PS, Lopez M (2005) J Agric Food Chem 53:8934–8939

    Article  CAS  Google Scholar 

  80. Hurtaud-Pessel D, Verdon E, Blot J, Sanders P (2006) Food Addit Contam 23:569–578

    Article  CAS  Google Scholar 

  81. Tittlemier SA, Van de Riet J, Burns G, Potter R, Murphy C (2007) Food Addit Contam 24:14–20

    Article  CAS  Google Scholar 

  82. Hu XZ, Xu Y, Yediler A (2007) J Agric Food Chem 55:1144–1149

    Article  CAS  Google Scholar 

  83. Chumanee S, Sutthivaiyakit S, Sutthivaiyakit P (2009) J Agric Food Chem 57:1752–1759

    Article  CAS  Google Scholar 

  84. http://en.wikipedia.org/wiki/Beta-lactam_antibiotic

  85. Samanidou VF, Nisyriou SA, Papadoyannis IN (2007) J Liq Chromatogr Relat Technol 30:1145–1204

    Article  CAS  Google Scholar 

  86. Aoyama RG, Kitts DD, Burt HM, McErlane KM (1992) J Chromatogr 626:271–276

    Article  CAS  Google Scholar 

  87. Luo W, Ang CYW, Thompson HC (1997) J Chromatogr B 694:401–407

    Article  CAS  Google Scholar 

  88. Gramse MJ, Jacobson PE (2005) J AOAC Int 88:679–683

    CAS  Google Scholar 

  89. Wang S, Zhang H, Wang L, Duan ZJ, Kennedy I (2006) Food Add Contam 23:362–384

    Article  CAS  Google Scholar 

  90. http://en.wikipedia.org/wiki/Sulfonamide_(medicine)

  91. Bogialli S, Curini R, di-Corcia A, Nazzari M, Samperi R (2003) Anal Chem 75:1798–1804

    Article  CAS  Google Scholar 

  92. Pecorelli I, Bibi R, Fioroni L, Galarini R (2004) J Chromatogr A 1039:23–29

    Article  Google Scholar 

  93. Gehring TA, Griffin B, Williams R, Geiseker C, Rushing LG, Ph S (2006) J Chromatogr B Anal Technol Biomed Life Sci 840:132–138

    Article  CAS  Google Scholar 

  94. Potter RA, Burns BG, van-de-Riet JM, North DH, Darvesh R (2007) J AOAC Int 90:343–348

    CAS  Google Scholar 

  95. Walter AM, Heilmeyert L (1969) Antibiotika-Fibel, 3rd edn. Thieme, Stuttgart

    Google Scholar 

  96. Gale EF, Folkes JP (1953) Biochem J 53:483–492

    CAS  Google Scholar 

  97. Oka H, Ito Y, Matsumoto HJ (2000) Chromatographic Analysis of tetracyclines in food 882:109–133

    CAS  Google Scholar 

  98. Pena AL, Lino CM, Silveira MI (2003) J AOAC Int 86:925–929

    CAS  Google Scholar 

  99. Coyne R, Bergh O, Samuelsen OB (2004) J Chromatogr B: Anal Technol Biomed Life Sci 810:325–328

    CAS  Google Scholar 

  100. Rupp HS, Anderson CR (2005) J AOAC Int 88:505–510

    CAS  Google Scholar 

  101. Schneider MJ, Darwish AM, Freeman DW (2007) Anal Chim Acta 586:269–274

    Article  CAS  Google Scholar 

  102. Wen Y, Wang Y, Feng YQ (2006) Talanta 70:153–159

    Article  CAS  Google Scholar 

  103. Saad B, Mohamada R, Mohamea N, Lawrence GD, Jaba MS, Saleh MI (2002) Food Chem 78:383–388

    Article  CAS  Google Scholar 

  104. Juan-Garcia A, Font G, Picó Y (2006) Electrophoresis 27:2240–2249

    Article  CAS  Google Scholar 

  105. Juan-Garcia A, Font G, Picó Y (2007) Electrophoresis 28:4180–4191

    Article  CAS  Google Scholar 

  106. Lu H, Wu X, Xie Z, Lin X et al (2005) J Sep Sci 28:2210–2217

    Article  CAS  Google Scholar 

  107. Wang L, Su X, Xie Z (2005) J Sep Sci 28:1143–1148

    Article  CAS  Google Scholar 

  108. Huang TS, Du WX, Marshall MR, Wei CI (1997) J Agric Food Chem 45:2602–2605

    Article  CAS  Google Scholar 

  109. Huet AC, Charlier C, Tittlemier SA, Singh G, Benrejeb S, Delahaut P (2006) J Agric Food Chem 54:2822–2827

    Article  CAS  Google Scholar 

  110. Zhang H, Wang L, Zhang Y, Fang G, Zheng W, Wang S (2007) J Agric Food Chem 55:2079–2084

    Article  CAS  Google Scholar 

  111. Cooper KM, Waddell A, Elliot CT, Kennedy DG (2004) Anal Chim Acta 520:79–86

    Article  CAS  Google Scholar 

  112. Diblikova I, Cooper KM, Kennedy DG, Frank M (2005) Anal Chim Acta 540:285–292

    Article  CAS  Google Scholar 

  113. Chang C, Peng DP, Wu JE, Wang YL, Yuan ZH (2008) J Agric Food Chem 56:1525–1531

    Article  CAS  Google Scholar 

  114. Pellinen T, Bylund G, Virta M, Niemi A, Karp M (2002) J Agric Food Chem 50:4812–4815

    Article  CAS  Google Scholar 

  115. Pei CJ, Zhang ZJ, Liu W (2006) Fenxi-Ceshi-Xuebao 25:83–85

    CAS  Google Scholar 

  116. Xiong Y, Zhou H, Zhang Z, He D, He C (2006) Analyst 131:829–834

    Article  CAS  Google Scholar 

  117. Sun XY, Chen H, Gao H, Guo XQ (2006) J Agric Food Chem 54:9685–9687

    Article  Google Scholar 

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Acknowledgements

Financial support was provided by DGI-MCI of Spain (Projects CTQ 2008-00468/BQU and CTQ 2008-06657-C02-01/BQU).

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  1. Department of Analytical Chemistry, University of Extremadura, Avda. Elvas, 06071, Badajoz, Spain

    F. Cañada-Cañada, A. Muñoz de la Peña & A. Espinosa-Mansilla

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  1. F. Cañada-Cañada
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  2. A. Muñoz de la Peña
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Correspondence to F. Cañada-Cañada.

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Cañada-Cañada, F., Muñoz de la Peña, A. & Espinosa-Mansilla, A. Analysis of antibiotics in fish samples. Anal Bioanal Chem 395, 987–1008 (2009). https://doi.org/10.1007/s00216-009-2872-z

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