Abstract
We report here on a method for preparation of precise laboratory solutions using controlled diffusion for dosing. The desired chemical is delivered into the target solution from a stock solution through a mass-transport-limiting delivery port that blocks convection but allows reproducible diffusive transport. Solution making with this approach involves a single step irrespective of how low the desired concentration is. Diffusional delivery of chemicals involves no appreciable movement of water and, thus, no addition of volume. The approach is therefore particularly suitable for standard addition. Precise solutions of usual laboratory volumes can be made within a short time period with proper design of the delivery port or ports. Comparison with the performance of conventional methods of routine solution preparation shows that better precision can be achieved with less labor using this approach.
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Acknowledgement
This study was partially funded by Vision Sensors LLC, Cleveland, OH, USA. The authors thankfully acknowledge the use of the atomic-absorption spectrophotometry equipment in Professor Aaron Jennings’ laboratory at CASE, and technical assistance by Jun Ma.
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Yoshida, M., Tohda, K. & Gratzl, M. Controlled diffusion for laboratory solution preparation. Anal Bioanal Chem 392, 471–477 (2008). https://doi.org/10.1007/s00216-008-2293-4
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DOI: https://doi.org/10.1007/s00216-008-2293-4