Abstract
A novel thermal desorption technique using a direct-probe device (Chromatoprobe) attached to a gas chromatograph–mass spectrometer is presented for the thermal pretreatment, characterisation and analysis of molecularly imprinted polymers. The technique is demonstrated as effective for the removal of volatile materials, including template and unreacted monomers, from methacrylic acid–ethylene glycol dimethacrylate copolymers imprinted with 2-aminopyridine. Mass spectrometry is a powerful technique for polymer bleed characterisation. Thermal desorption studies on reloaded template and related compounds are reported as a means of assessing polymer morphology, specific binding by imprinted polymers compared with reference non-imprinted polymers and selective binding by an imprinted polymer for its template. Calibration studies on the thermal desorption technique using an internal standard are presented with R 2 > 0.999. The technique provides a novel method for assessment of polymer thermal stability, composition and morphology.
Similar content being viewed by others
References
Levchik GF, Si K, Levchik SV, Camino G, Wilkie CA (1999) Polym Degrad Stab 65:395–403
Uhl FM, Levchik GF, Levchik SV, Dick C, Liggat JJ, Snape CE, Wilkie CA (2001) Polym Degrad Stab 71:317–325
Wainhaus SB, Tzanani N, Dagan S, Miller ML, Amirav A (1998) J Am Soc Mass Spectrom 9:1311–1320
Kochman M, Gordin A, Goldshlag P, Lehotay SJ, Amirav A (2002) J Chromatogr A 974:185–212
Orioli M, Marinello C, Cozzi R, Piodi LP, Carini M (2004) J Pharm Biomed Anal 35:1263–1272
Shea KJ, Spivak DA, Sellergren B (1993) J Am Chem Soc 115:3368–3369
Spivak D, Gilmore MA, Shea KJ (1997) J Am Chem Soc 119:4388–4393
Spivak DA, Shea KJ (1998) Macromolecules 31:2160–2165
Jie Z, Xiwen H (1999) Anal Chim Acta 381:85–91
Cummins W, Duggan P, McLoughlin P (2005) Anal Chim Acta 542:52–60
Cummins W, Duggan P, McLoughlin P (2006) Biosens Bioelectron 22:372–380
Varian (2007) Varian, Inc scientific instruments and vacuum products. http://www.varininc.com
Acknowledgement
Financial support of this work from the Technological Sector Research Initiative (2001) (Strand 111) is gratefully acknowledged.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cummins, W., Duggan, P. & McLoughlin, P. Thermal desorption characterisation of molecularly imprinted polymers. Part I: a novel study using direct-probe GC-MS analysis. Anal Bioanal Chem 391, 1237–1244 (2008). https://doi.org/10.1007/s00216-008-1965-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00216-008-1965-4