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HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds


Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)–electrospray tandem mass spectrometry and HPLC–inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H2S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H2Se.

H2Se bubbled into solutions containing oxo‐arsenosugars converts them into their seleno‐arsenosugar analogues.

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  1. Chen CJ, Chuang YC, Lin TM, Wu HY (1985) Cancer Res 45:5895–5899

    CAS  Google Scholar 

  2. Smith AH, Goycolea M, Haque R, Biggs ML (1998) Am J Epidemiol 147:660–669

    CAS  Google Scholar 

  3. Levander OA, Argrett LC (1969) Toxicol Appl Pharmacol 14:308–314

    Article  CAS  Google Scholar 

  4. Moxon AL (1938) Science 88:81

    Article  CAS  Google Scholar 

  5. Levander OA, Baumann CA (1966) Toxicol Appl Pharmacol 9:98–105

    Article  CAS  Google Scholar 

  6. Levander OA, Baumann CA (1966) Toxicol Appl Pharmacol 9:106–115

    Article  CAS  Google Scholar 

  7. Hsieh HS, Ganther HE (1975) Biochemistry 14:1632–1636

    Article  CAS  Google Scholar 

  8. Gailer J, George GN, Pickering IJ, Prince RC, Ringwald SC, Pemberton JE, Glass RS, Younis HS, DeYoung DW, Aposhian HV (2000) J Am Chem Soc 122:4637–4639

    Article  CAS  Google Scholar 

  9. Hansen HR, Pickford R, Thomas-Oates J, Jaspars M, Feldmann J (2004) Angew Chem Int Ed Engl 43:337–340

    Article  CAS  Google Scholar 

  10. Fricke MW, Creed PA, Parks AN, Shoemaker JA, Schwegel CA, Creed JT (2004) J Anal At Spectrom 19:1454–1459

    Article  CAS  Google Scholar 

  11. Schmeisser E, Raml R, Francesconi KA, Kuehnelt D, Lindberg A-L, Sörös C, Goessler W (2004) Chem Commun 1824–1825

  12. Kahn M, Raml R, Schmeisser E, Vallant B, Francesconi KA, Goessler W (2005) Environ Chem 2:171–176

    Article  CAS  Google Scholar 

  13. Nischwitz V, Kanaki K, Pergantis SA (2006) J Anal At Spectrom 21:33–40

    Article  CAS  Google Scholar 

  14. Hansen HR, Jaspars M, Feldmann J (2004) Analyst 129:1058–1064

    Article  CAS  Google Scholar 

  15. McSheehy S, Marcinek M, Chassaigne H, Szpunar J (2000) Anal Chim Acta 410:71–84

    Article  CAS  Google Scholar 

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The authors thank the European Commission for the funding of a Marie Curie Excellence Grant (contract no. MEXT-CT-2003-002788).

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Correspondence to Spiros A. Pergantis.

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Kanaki, K., Pergantis, S.A. HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds. Anal Bioanal Chem 387, 2617–2622 (2007).

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  • Arsenic
  • Selenium
  • Speciation
  • Inductively coupled plasma mass spectrometry
  • Electrospray tandem mass spectrometry