Skip to main content

HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds

Analytical and Bioanalytical Chemistry volume 387, pages 2617–2622 (2007)Cite this article

Abstract

Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)–electrospray tandem mass spectrometry and HPLC–inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H2S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H2Se.

H2Se bubbled into solutions containing oxo‐arsenosugars converts them into their seleno‐arsenosugar analogues.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Scheme 1
Fig. 1
Scheme 2
Fig. 2
Scheme 3

References

  1. Chen CJ, Chuang YC, Lin TM, Wu HY (1985) Cancer Res 45:5895–5899

    CAS  Google Scholar 

  2. Smith AH, Goycolea M, Haque R, Biggs ML (1998) Am J Epidemiol 147:660–669

    CAS  Google Scholar 

  3. Levander OA, Argrett LC (1969) Toxicol Appl Pharmacol 14:308–314

    Article  CAS  Google Scholar 

  4. Moxon AL (1938) Science 88:81

    Article  CAS  Google Scholar 

  5. Levander OA, Baumann CA (1966) Toxicol Appl Pharmacol 9:98–105

    Article  CAS  Google Scholar 

  6. Levander OA, Baumann CA (1966) Toxicol Appl Pharmacol 9:106–115

    Article  CAS  Google Scholar 

  7. Hsieh HS, Ganther HE (1975) Biochemistry 14:1632–1636

    Article  CAS  Google Scholar 

  8. Gailer J, George GN, Pickering IJ, Prince RC, Ringwald SC, Pemberton JE, Glass RS, Younis HS, DeYoung DW, Aposhian HV (2000) J Am Chem Soc 122:4637–4639

    Article  CAS  Google Scholar 

  9. Hansen HR, Pickford R, Thomas-Oates J, Jaspars M, Feldmann J (2004) Angew Chem Int Ed Engl 43:337–340

    Article  CAS  Google Scholar 

  10. Fricke MW, Creed PA, Parks AN, Shoemaker JA, Schwegel CA, Creed JT (2004) J Anal At Spectrom 19:1454–1459

    Article  CAS  Google Scholar 

  11. Schmeisser E, Raml R, Francesconi KA, Kuehnelt D, Lindberg A-L, Sörös C, Goessler W (2004) Chem Commun 1824–1825

  12. Kahn M, Raml R, Schmeisser E, Vallant B, Francesconi KA, Goessler W (2005) Environ Chem 2:171–176

    Article  CAS  Google Scholar 

  13. Nischwitz V, Kanaki K, Pergantis SA (2006) J Anal At Spectrom 21:33–40

    Article  CAS  Google Scholar 

  14. Hansen HR, Jaspars M, Feldmann J (2004) Analyst 129:1058–1064

    Article  CAS  Google Scholar 

  15. McSheehy S, Marcinek M, Chassaigne H, Szpunar J (2000) Anal Chim Acta 410:71–84

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The authors thank the European Commission for the funding of a Marie Curie Excellence Grant (contract no. MEXT-CT-2003-002788).

Author information

Authors and Affiliations

  1. Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Voutes, 71003 Heraklion, Crete, Greece

    Katerina Kanaki & Spiros A. Pergantis

Authors
  1. Katerina Kanaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Spiros A. Pergantis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Spiros A. Pergantis.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kanaki, K., Pergantis, S.A. HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds. Anal Bioanal Chem 387, 2617–2622 (2007). https://doi.org/10.1007/s00216-007-1171-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-007-1171-9

Keywords

  • Arsenic
  • Selenium
  • Speciation
  • Inductively coupled plasma mass spectrometry
  • Electrospray tandem mass spectrometry