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HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds

Abstract

Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)–electrospray tandem mass spectrometry and HPLC–inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H2S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H2Se.

H2Se bubbled into solutions containing oxo‐arsenosugars converts them into their seleno‐arsenosugar analogues.

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Acknowledgement

The authors thank the European Commission for the funding of a Marie Curie Excellence Grant (contract no. MEXT-CT-2003-002788).

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Correspondence to Spiros A. Pergantis.

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Kanaki, K., Pergantis, S.A. HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds. Anal Bioanal Chem 387, 2617–2622 (2007). https://doi.org/10.1007/s00216-007-1171-9

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  • DOI: https://doi.org/10.1007/s00216-007-1171-9

Keywords

  • Arsenic
  • Selenium
  • Speciation
  • Inductively coupled plasma mass spectrometry
  • Electrospray tandem mass spectrometry