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Development of restricted-access media supports and their application to the direct analysis of biological fluid samples via high-performance liquid chromatography

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Abstract

A quick overview of published methods for analyzing compounds in complex biological samples reveals that the most difficult step is the clean-up or extraction of a required compound from the matrix. The strategy required to analyze exogenous compounds in biological fluids depends greatly upon the nature of the compound and upon the biomatrix. Coupled-column separation using restricted-access media as the first dimension in order to exclude macromolecules and retain micromolecules has been successfully used for a number of biological fluids. This paper presents the history of the development of restricted-access media supports and of their application to the direct injection of biological fluid samples in high-performance liquid chromatography.

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Fig. 1
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Fig. 4a–b
Fig. 5a–b

Abbreviations

ADS:

alkyl-diol-silica phase

BSA:

Bovine Albumin Serum

HAS:

Human Serum Albumin

ISPBA:

internal surface phenylboronic acid

ISRP:

internal surface reversed phase

MFP:

mixed function phase

SHP:

shielded hydrophobic phase

SPS:

semipermeable surface

XDS:

exchange diol silica

CMC:

chiral multidimensional chromatography

MC:

multidimensional chromatography

SC:

single-column

AD:

amperometric detector

DAD:

diode-array detector

FD:

fluorescence detection

MS:

mass spectrometry detection

UV:

ultraviolet detection

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Authors and Affiliations

  1. Departamento de Química, Universidade Federal de São Carlos, Cx. Postal 676, São Carlos, SP, 13565-905, Brazil

    N. M. Cassiano, V. V. Lima, R. V. Oliveira, A. C. de Pietro & Q. B. Cass

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  1. N. M. Cassiano
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  2. V. V. Lima
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  3. R. V. Oliveira
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  4. A. C. de Pietro
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  5. Q. B. Cass
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Correspondence to Q. B. Cass.

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Cassiano, N.M., Lima, V.V., Oliveira, R.V. et al. Development of restricted-access media supports and their application to the direct analysis of biological fluid samples via high-performance liquid chromatography. Anal Bioanal Chem 384, 1462–1469 (2006). https://doi.org/10.1007/s00216-005-0253-9

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