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Trends in the development of nucleic acid biosensors for medical diagnostics

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Abstract

Some of the recent advances in the field of biosensors for nucleic acid analysis in medical diagnostic applications are highlighted. Particular attention is paid in this review to the progress made in two key areas of development: (i) enhancements achieved in device selectivity, and (ii) enhancements achieved in device sensitivity.

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Abbreviations

DNA:

Deoxyribonucleic acid

SNP:

Single nucleotide polymorphism

T m :

Melt temperature

AFM:

Atomic force microscopy

SERS:

Surface enhanced Raman spectroscopy

PCR:

Polymerase chain reaction

OTC:

Occult tumour cells

WBC:

White blood cells

BOD:

Bilirubin oxidase

CNT:

Carbon nanotube

ALP:

Alkaline phosphatase

8G:

7,8-dihydro-8-oxoguanine

5U:

5-aminouridine

MB:

Molecular beacon

LoD:

Limit of detection

SELEX:

Systematic evolution of ligands by exponential enrichment

SiNW:

Silicon nanowire

PNA:

Peptide nucleic acid

SPR:

Surface plasmon resonance

FRET:

Fluorescence resonance energy transfer

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Authors and Affiliations

  1. Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario, L5L 1C6, Canada

    Paul A. E. Piunno & Ulrich J. Krull

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  1. Paul A. E. Piunno
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  2. Ulrich J. Krull
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Piunno, P.A.E., Krull, U.J. Trends in the development of nucleic acid biosensors for medical diagnostics. Anal Bioanal Chem 381, 1004–1011 (2005). https://doi.org/10.1007/s00216-004-3024-0

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  • DOI: https://doi.org/10.1007/s00216-004-3024-0

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