Skip to main content
Log in

Voltammetric behaviour and determination of moxifloxacin in pharmaceutical products and human plasma

  • Original Paper
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript


The oxidative behaviour of moxifloxacin was studied at a glassy carbon electrode in different buffer systems using cyclic, differential pulse, and Osteryoung square-wave voltammetry. The oxidation process was shown to be irreversible over the entire pH range studied (2.0–10.0) and was diffusion-controlled. The methods were performed in Britton–Robinson buffer and the corresponding calibration graphs were constructed and statistical data were evaluated. When the proposed methods were applied at pH 6.0 linearity was achieved from 4.4×10−7 to 1.0×10−5 mol L−1. Applicability to tablets and human plasma analysis was illustrated. Furthermore, a high-performance liquid chromatographic method with diode-array detection was developed. A calibration graph was established from 4.0×10−6 to 5.0×10−5 mol L−1 moxifloxacin. The described methods were successfully employed with high precision and accuracy for estimation of the total drug content of human plasma and for pharmaceutical dosage forms of moxifloxacin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others


  1. Woodcock JM, Andrews JM, Broswell FJ, Brenwald NP, Wise R (1997) Antimicrob Agents Chemother 41:101–106

    CAS  PubMed  Google Scholar 

  2. Fass RJ (1997) Antimicrob Agents Chemother 41:1818–1824

    CAS  PubMed  Google Scholar 

  3. Roblin PM, Hammerschlag MR (1998) Antimicrob Agents Chemother 42:951–952

    CAS  PubMed  Google Scholar 

  4. Donati M, Rodriguez FM, Olmo A, D’Apote L, Ceveni R (1999) Antimicrob Agents Chemother 43:825–827

    Article  CAS  Google Scholar 

  5. Biedenbach DL, Barrett MS, Croco MAT, Jones RN (1998) Diagn Microbiol Infect Dis 32:45–50

    Article  CAS  PubMed  Google Scholar 

  6. Stass H, Dalhoff A (1997) J Chromatogr 702:163–174

    Article  CAS  Google Scholar 

  7. Lemoine T, Breilh D, Ducint D, Dubrez J, Jougon J, Velly JF, Saux MC (2000) J Chromatogr B 742:247–254

    Article  CAS  Google Scholar 

  8. Ba BB, Etienne R, Ducint D, Quentin C, Saux MC (2001) J Chromatogr B 754:107–112

    Article  CAS  Google Scholar 

  9. Vishwanathan K, Bartlett MG, Stewart JT (2002) J Pharm Biomed Anal 30:961–968

    Article  CAS  PubMed  Google Scholar 

  10. Liang H, Kays MB, Sowinski KM (2002) J Chromatogr B 772:53–63

    Google Scholar 

  11. Ocana JA, Barragan FJ, Callejon M (2000) Analyst 125:2322–2325

    Article  CAS  PubMed  Google Scholar 

  12. Biryol İ, Erk N (2003) Anal Lett 36:2699–2711

    Article  Google Scholar 

  13. Erk N (2003) Die Pharmazie 58:870–873

    CAS  PubMed  Google Scholar 

  14. Erk N, Biryol İ (2003) Die Pharmazie 58:699–704

    CAS  PubMed  Google Scholar 

  15. Nigovic B, Simunic B (2003) J Pharm Biomed Anal 31:169–174

    Article  CAS  PubMed  Google Scholar 

  16. Vilchez JL, Taoufiki J, Araujo L, Navalon A (2003) J Pharm Biomed Anal 31:465–471

    Article  CAS  PubMed  Google Scholar 

  17. Ghoneim MM, Mabrouk MM, Tawfik A (2002) J Pharm Biomed Anal 31:1–8

    Google Scholar 

  18. Radi A, El-Sherif Z (2002) Talanta 58:319–324

    Article  CAS  Google Scholar 

  19. Gosser DK (1993) In: Cyclic voltammetry simulation and analysis of reaction mechanisms. VCH, New York, p 43

  20. Bard A, Faulkner LR (2001) Electrochemical methods: fundamentals and applications, 2nd edn. Wiley, New York, p 236

    Google Scholar 

  21. International Conference on Harmonisation, Notes for Guidance,

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to N. Erk.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erk, N. Voltammetric behaviour and determination of moxifloxacin in pharmaceutical products and human plasma. Anal Bioanal Chem 378, 1351–1356 (2004).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: