Skip to main content

Present and future of surface plasmon resonance biosensors

Analytical and Bioanalytical Chemistry volume 377, pages 528–539 (2003)Cite this article

Abstract

Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves—surface plasmon-polaritons—to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.
Fig. 11.
Fig. 12.
Fig. 13.
Fig. 14.
Fig. 15.
Fig. 16.
Fig. 17.
Fig. 18.

References

  1. Ghindilis AL, Atanasov P, Wilkins M, Wilkins E (1998) Biosens Bioelectron 13:113–131

    Article  CAS  PubMed  Google Scholar 

  2. Chu X, Lin ZH, Shen GL, Yu RQM (1995) Analyst 120:2829–2832

    CAS  PubMed  Google Scholar 

  3. Gauglitz G (1996) Opto-chemical and opto-immuno sensors, sensor update, vol 1. VCH, Weinheim

  4. Rowe-Taitt CA, Hazzard JW, Hoffman KE, Cras JJ, Golden JP, Ligler FS (2000) Biosens Bioelectron 15:579–589

    Article  CAS  PubMed  Google Scholar 

  5. Piehler J, Brecht A, Gauglitz G (1996) Anal Chem 68:139–143

    CAS  Google Scholar 

  6. Heideman RG, Kooyman RPH, Greve J (1993) Sens Actuators B 10:209–217

    Article  CAS  Google Scholar 

  7. Clerc D, Lukosz W (1994) Sens Actuators B 19:581–586

    Article  CAS  Google Scholar 

  8. Cush R, Cronin JM, Stewart WJ, Maule CH, Molloy J, Goddard NJ (1993) Biosens Bioelectron 8:347–353

    Article  CAS  Google Scholar 

  9. Homola J, Yee S, Gauglitz G (1999) Sens Actuators B 54:3–15

    Article  Google Scholar 

  10. Homola J, Yee S, Myszka D (2002) Surface plasmon biosensors. In: Ligler FS, Taitt CR (eds) Optical biosensors: present and future. Elsevier

  11. Rabbany SY, Lane WJ, Marganski WA, Kusterbeck AW, Ligler FS (2000) J Immunol Methods 246:69–77

    Article  CAS  PubMed  Google Scholar 

  12. Boardman AD (1982) (ed) Electromagnetic surface modes. Wiley, Chichester

  13. Reather H (1983) Surface plasmons on smooth and rough surfaces and on gratings, Springer tracts in modern physics, vol 111. Springer, Berlin Heidelberg New York

  14. Snyder AW, Love JD (1983) Optical waveguide theory. Chapman and Hall, London

  15. Parriaux O, Voirin G (1990) Sens Actuators A 21–23:1137

  16. Hutley MC (1982) Diffration gratings. Academic Press, London

  17. Kooyman RPH, Kolkman H, van Gent J, Greve J (1988) Anal Chim Acta 213:35–45

    Article  CAS  Google Scholar 

  18. Yeatman EM (1996) Biosens Bioelectron 11:635–649

    Article  CAS  Google Scholar 

  19. Homola J (1997) Sens Actuators B 41:207–211

    Article  Google Scholar 

  20. Homola J, Koudela I, Yee S (1999) Sens Actuators B 54:16–24

    Article  Google Scholar 

  21. Edwards PR, Leatherbarrow RJ (1997) Anal Biochem 246:1–6

    Article  CAS  PubMed  Google Scholar 

  22. Vijayendran RA, Ligler FS, Leckband DE (1999) Anal Chem 71:5405–5412

    Article  CAS  Google Scholar 

  23. Löfås S, Malmqvist M, Rönnberg I, Stenberg E, Liedberg B, Lundström I (1991) Sens Actuators B 5:79

    Article  Google Scholar 

  24. Nenninger GG, Clendenning JB, Furlong CE, Yee S (1998) Sens Actuators B51:38

    CAS  Google Scholar 

  25. Jordan CE, Frutos AG, Thiel AJ, Corn RM (1997) Anal Chem 69:4939

    CAS  Google Scholar 

  26. Nikitin PI, Beloglazov AA, Kabashin AV, Valeiko MV, Kochergin V E (1999) Sens Actuators B54:43

    CAS  Google Scholar 

  27. Kano H, Knoll W (2000) Optics Communications 182:11–15

    Article  CAS  Google Scholar 

  28. Kabashin A V, Nikitin P I (1998) Opt Commun 150:5–8

    Article  CAS  Google Scholar 

  29. Nelson BP, Frutos AG, Brockman JM, Corn RM (1999) Anal Chem 71:3928–3934

    Article  CAS  Google Scholar 

  30. Johnasen K, Arwin H, Lundström I, Liedberg B (2000) Rev Sci Instrum 71:3530–3538

    Article  Google Scholar 

  31. Rothenhäusler B, Knoll W (1988) Nature 332:688

    Google Scholar 

  32. Dostálek J, Homola J, Miler M (2002) EUROPT(R)ODE VI, Manchester, UK, Book of Abstracts, 265

  33. Homola J, Dostálek J, Čtyroký J (2001) Proc SPIE 4416:86

    CAS  Google Scholar 

  34. Homola J, Lu HB, Yee S (1999) Electr Lett 35:1105

    Article  CAS  Google Scholar 

  35. Homola J, Lu HB, Nenninger GG, Dostálek J, Yee S (2001) Sens Actuators B76:403–410

    CAS  Google Scholar 

  36. Ober RJ, Ward E S (1999) Anal Biochem 271:70–80

    Article  CAS  PubMed  Google Scholar 

  37. Homola J, Dostálek J, Piliarik M, Yee S (2002) EUROPT(R)ODE VI, Manchester, UK, Book of Abstracts, 71

  38. Stemmler I, Brecht A, Gauglitz G (1999) Sens Actuators B 54:98–105

    Article  Google Scholar 

  39. Jorgenson RC, Yee S (1993) Sens Actuators B12:213

    Google Scholar 

  40. Homola J (1995) Sens Actuators B 29:401–405

    Article  Google Scholar 

  41. Homola J, Piliarik M, Slavík R, Čtyroký J (2001) SPIE Proc 4416:82–85

    Google Scholar 

  42. Piliarik M, Homola J, Maníková Z, Čtyroký J (2003) Sens Actuators B 90:236–242

    Google Scholar 

  43. Nenninger GG, Tobiška P, Homola J, Yee S (2001) Sens Actuators B74:145

    CAS  Google Scholar 

  44. Liedberg B, Lundstrom I, Stenberg E (1993) Sens Actuators B11:63

    CAS  Google Scholar 

  45. Johnston KS, Booksh KS, Chinowsky TM, Yee S (1999) Sens Actuators B 54:80–88

    Article  Google Scholar 

  46. Chinowsky TM, Jung LS, Yee S (1999) Sens Actuators B 54:89–97

    Article  Google Scholar 

  47. Johansen K, Stålberg R, Lunström I, Liedberg B (2000) Meas Sci Technol 11:1630–1638

    Article  CAS  Google Scholar 

  48. Johansen K, Lundström I, Liedberg B (2000) Biosens Bioelectron 15:503–509

    Article  CAS  PubMed  Google Scholar 

  49. Nenninger GG, Piliarik M, Homola J (2002) Meas Sci Technol 13:2038–2046

    Article  CAS  Google Scholar 

  50. Morgan H, Taylor DM, (1992) Biosens Bioelectron 7:405–410

    Article  CAS  PubMed  Google Scholar 

  51. Duschl C, Sevin-Landais A, Vogel H (1995) Biophys J 70:1985

    Google Scholar 

  52. Löfås S, Malmqvist M, Rönnberg I, Stenberg E, Liedberg B, Lundström I (1991) Sens Actuators B 5:79

    Article  Google Scholar 

  53. Nakamura R, Muguruma H, Ikebukuro K, Sasaki S, Nagata R, Karube I, Pedersen H (1997) Anal Chem 69:4649

    Article  CAS  Google Scholar 

  54. Lu HB, Homola J, Campbell CT, Nenninger GG, Yee S, Ratner BD (2001) Sens Actuators B 74:91–99

    Article  Google Scholar 

  55. Watts HJ, Yeung D, Parkes H (1995) Anal Chem 67:4283–4289

    CAS  PubMed  Google Scholar 

  56. Brockman JM, Frutos AG, Corn RM (1999) J Am Chem Soc 121:8044–8051

    Article  CAS  Google Scholar 

  57. Lai EPC, Fafara A, VanderNoot VA, Kono M, Polsky B (1998) Can J Chem 76:265–273

    Article  CAS  Google Scholar 

  58. Rich RL, Myszka DG (2002) J Mol Recognit 15:352–376

    Article  CAS  PubMed  Google Scholar 

  59. Severs AH, Schasfoort RBM (1993) Biosens Bioelectron 8:365

    Article  CAS  Google Scholar 

  60. Leung PT, Pollard-Knight D, Malan GP, Finlan MF (1994) Sens Actuators B22:175

    CAS  Google Scholar 

  61. Minunni M, Mascini M (1993) Anal Lett 26:1441

    CAS  Google Scholar 

  62. Mouvet C, Harris RD, Maciag C, Luff BJ, Wilkinson JS, Piehler J, Brecht A, Gauglitz G, Abuknesha R, Ismail G (1997) Anal Chim Acta 338:109

    Article  CAS  Google Scholar 

  63. Harris RD, Luff BJ, Wilkinson JS, Piehler J, Brecht A, Gauglitz G, Abuknesha RA (1999) Biosens Bioelectron 14:377

    Article  CAS  PubMed  Google Scholar 

  64. Miura N, Ogata K, Sakai G, Uda T, Yamazoe N (1997) Chem Lett 8:713

    Google Scholar 

  65. Sakai G, Nakata S, Uda T, Miura N, Yamazoe N (1999) Electrochim Acta 44:3849

    Article  CAS  Google Scholar 

  66. Mullett W, Edward PC, Yeung MJ (1998) Anal Biochem 258:161–167

    Article  CAS  PubMed  Google Scholar 

  67. Sternesjo A, Mellgren C, Bjorck L (1996) ACS Symp Ser 621:463–470

    Google Scholar 

  68. Gaudin V, Pavy M-L (1999) JAOAC Int 82:1316–1320

    CAS  Google Scholar 

  69. Baxter GA, Ferguson JP, O'Conner MC, Elliott CT (2001) J Agric Food Chem 49:3204–3207

    Article  CAS  PubMed  Google Scholar 

  70. Elliot CT, Baxter GA, Crooks SRH, McCaughey WJ (1999) Food Agric Immunol 11:19–28

    Article  Google Scholar 

  71. Choi K, Seo W, Cha S, Choi J (1998) J Biochem Mol Biol 31:101–105

    CAS  Google Scholar 

  72. Spangler BD, Wilkinson EA, Murphy JT, Tyler BJ (2001) Anal Chim Acta 444:149–161

    Article  CAS  Google Scholar 

  73. Rasooly A (2001) J Food Prot 64:37–43

    CAS  PubMed  Google Scholar 

  74. Homola J, Dostálek J, Chen S, Rasooly A, Jiang S, Yee S (2002) Int J Food Microbiol 75:61–69

    Article  CAS  PubMed  Google Scholar 

  75. Fratamico PM, Strobaugh TP, Medina MB, Gehring AG (1998) Biotechnol Tech 12:571–576

    Article  CAS  Google Scholar 

  76. Koubová V, Brynda E, Karasová L, Škvor J, Homola J, Dostálek J, Tobiška P, Rošický J (2001) Sens Actuators B 74:100–105

    Article  Google Scholar 

  77. Perkins EA, Squirrell DJ (2000) Biosens Bioelectron 14:853

    Article  CAS  PubMed  Google Scholar 

  78. Biacore websitewww.biacore.com

  79. IBIS Technologies website www.ibis-spr.nl

  80. Nippon Laser and Electronics Laboratory website www.nle-lab.co.jp/English/ZO-HOME.htm

  81. Texas Instruments website www.ti.com/sc/docs/products/msp/control/spreeta

  82. Analytical μ-Systems website www.micro-systems.de

Download references

Acknowledgement

This work was supported by the Grant Agency of the Czech Republic under contracts 102/03/0633, 303/03/0249, and 203/02/1326.

Author information

Affiliations

  1. Institute of Radio Engineering and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic

    Jiří Homola

Authors
  1. Jiří Homola
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiří Homola.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Homola, J. Present and future of surface plasmon resonance biosensors. Anal Bioanal Chem 377, 528–539 (2003). https://doi.org/10.1007/s00216-003-2101-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-003-2101-0

Keywords

  • Optical sensor
  • Biosensor
  • Affinity biosensor
  • Immunosensor
  • Surface plasmon resonance