Abstract
Two new standard reference materials (SRM) for drugs of abuse in human hair have been developed. SRM 2379 consists of hair spiked with cocaine, benzoylecgonine, cocaethylene, phencyclidine, amphetamine, and methamphetamine. SRM 2380 consists of hair spiked with codeine, morphine, monoacetylmorphine, and tetrahydrocannabinol (THC). The SRMs were prepared by soaking the hair in a solution of the target analytes in water-dimethylsulfoxide. The concentration of each analyte was determined using two methods, one based upon gas chromatography/mass spectrometry (GC/MS) and one based upon liquid chromatography/mass spectrometry (LC/MS). Both methods used 0.1 M HCl for extraction of all the analytes from the hair, except for THC, which was extracted with 1 M NaOH. For isolation of the analytes from the extracts, the GC/MS-based methods used different clean-up procedures from those used for the LC/MS-based methods. The results from the two methods were in good agreement with mean differences for the analytes ranging from 4% to 16%. These materials will enable laboratories performing analyses of hair for drugs of abuse to test the accuracy of their methods.
Similar content being viewed by others
References
Staub C (1995) Forensic Sci Int 70:111–123
Selavka C, Rieders F (1995) Forensic Sci Int 70:155–164
Sachs H, Kintz P (1998) J Chromatogr B 713:147–161
Welch MJ, Sniegoski LT, Allgood CC (1993) Forensic Sci Int 63:295–303
Welch MJ, Sniegoski LT (1995) NIH Publication No. 95–3727:133–147
Sniegoski LT, Welch MJ (1996) J Anal Tox 20:242–247
Welch MJ, Sniegoski L T (1999) NISTIR 6486
Kintz P (1995) Forensic Sci Int 7:105–109
Montagna M, Polettini A, Stamesi C, Groppi A, Vignali C (2002) Forensic Sci Int 128:79–83
Welch MJ, Ellerbe P, Tai SSC, Christensen RG, Sniegoski LT, Sander LC, Phinney CS (1995) Fresenius J Anal Chem 352:61–65
Levenson MS, Banks DL, Eberhardt KR, Gill LM, Guthrie WF, Liu HK, Vangel MG, Yen JH, Ahang NF (2000) J Res Ntl Inst Stnd Techno 105:571–579
May W, Parris R, Beck C, Fassett J, Greenberg R, Guenther F, Kramer G, Wise S, Gills T, Colbert J (2000) NIST Special Publication 260–136
Welch MJ, Sniegoski LT, Allgood CC, Habram M (1993) J Anal Tox 17:389–396
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Welch, M.J., Sniegoski, L.T. & Tai, S. Two new standard reference materials for the determination of drugs of abuse in human hair. Anal Bioanal Chem 376, 1205–1211 (2003). https://doi.org/10.1007/s00216-003-2061-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00216-003-2061-4